Bicyclic nucleoside inhibitors of varicella-zoster virus: 5′-chloro and 3′-chloro derivatives

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 931-933

  Luoni, G ^a   McGuigan, C ^a   Andrei, G ^b   Snoeck, R ^b   De Clercq, E ^b   Balzarini, J ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral; Chloronucleoside; Varicella Zoster Virus

Indexed keywords

3' CHLORONUCLEOSIDE DERIVATIVE; 5' CHLORONUCLEOSIDE DERIVATIVE; ANTIVIRUS AGENT; NUCLEOSIDE DERIVATIVE; PALLADIUM; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOMEGALOVIRUS; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS CELL; VARICELLA ZOSTER VIRUS; VIRUS REPLICATION;

ANTIVIRAL AGENTS; BICYCLO COMPOUNDS; CYTOMEGALOVIRUS; DRUG DESIGN; FLUORIDES; HERPESVIRUS 3, HUMAN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINE NUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP; XYLOSE;

CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 3;

EID: 0141708108     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022688     Document Type: Conference Paper

References (3)

1. McGuigan, C.; Yarnold, C.J.; Jones, G.; Velazquez, S.; Barucki, H.; Brancale, A.; Andrei, G.; Snoeck, R.; De Clercq, E.; Balzarini, J. Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base. J. Med. Chem. 1999, 42, 4479-4484.
2. McGuigan, C.; Baruki, H.; Blewett, S.; Carangio, A.; Erichsen, J.T.; Andrei, G.; Snoeck, R.; De Clercq, E.; Balzarini, J. Highly potent ans selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain. J. Med. Chem. 2000, 43, 4993-4997.
3. Verheyden, J.P.H.; Moffatt, J.G. Halo sugar nucleosides. III. Reactions for the chlorination and bromination of nucleoside hydroxyl groups. J. Org. Chem. 1972, 37, 2289-2299.