Catechol-O-methyltransferase and monoamine oxidase A genotypes and drug response to conventional neuroleptics in schizophrenia

Journal of Clinical Psychopharmacology

Volumn 23, Issue 5, 2003, Pages 429-434

  Illi, Ari ^a,b   Mattila, Kari M ^a,b   Kampman, Olli ^b,c   Anttila, Sami ^b   Roivas, Markus ^a   Lehtimäki, Terho ^a   Leinonen, Esa ^a,b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^c Tampere Community Mental Health Care   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; CATECHOL METHYLTRANSFERASE; DOPAMINE; NEUROLEPTIC AGENT; NEUROTRANSMITTER; NORADRENALIN; SEROTONIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SYNTHESIS; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; METABOLISM; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SCHIZOPHRENIA;

ADULT; ANTIPSYCHOTIC AGENTS; CATECHOL O-METHYLTRANSFERASE; CHI-SQUARE DISTRIBUTION; FEMALE; GENOTYPE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MONOAMINE OXIDASE; ODDS RATIO; SCHIZOPHRENIA;

EID: 0141706764     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jcp.0000088916.02635.33     Document Type: Article

References (29)

1. Weinshilboum RM, Raymond FA. Inheritance of low erythrocyte catechol-o-methyltransferase activity in man. Am J Hum Genet. 1977;29:125-135.
2. Spielman RS, Weinshilboum RM. Genetics of red cell COMT activity: analysis of thermal stability and family data. Am J Med Genet. 1981;10:279-290.
3. Lotta T, Vidgren J, Tilgmann C, et al. Kinetics of human soluble and membrane-bound catechol-O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry. 1995;34:4202-4210.
4. Lachman HM, Papolos DF, Saito T, et al. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics. 1996;6:243-250.
5. Daniels JK, Williams NM, Williams J, et al. No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity. Am J Psychiatry. 1996;153:268-270.
6. Strous RD, Bark N, Woemer M, et al. Lack of association of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia. Biol Psychiatry. 1997;41:493-495.
7. Chen CH, Lee YR, Wei FC, et al. Association study of NlaIII and MspI genetic polymorphisms of catechol-O-methyltransferase gene and susceptibility to schizophrenia. Biol Psychiatry. 1997;41:985-987.
8. Karayiorgou M, Gogos JA, Galke BL, et al. Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility. Biol Psychiatry. 1998;43:425-431.
9. Ohmori O, Shinkai T, Kojima H, et al. Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics. Neurosci Lett. 1998;243:109-112.
10. Lachman HM, Nolan KA, Mohr P, et al. Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder. Am J Psychiatry. 1998;155:835-837.
11. Strous RD, Bark N, Parsia SS, et al. Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior. Psychiatry Res. 1997;69:71-77.
12. Kotler M, Barak P, Cohen H, et al. Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity. Am J Med Genet. 1999;88:628-633.
13. de Chaldee M, Laurent C, Thibaut F, et al. Linkage disequilibrium on the COMT gene in French schizophrenics and controls. Am J Med Genet. 1999;88:452-457.
14. de Chaldee M, Corbex M, Campion D, et al. No evidence for linkage between COMT and schizophrenia in a French population. Psychiatry Res. 2001;102:87-90.
15. Egan MF, Goldberg TE, Kolachana BS, et al. Effect of COMT Val108/ 158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA. 2001;98:6917-6922.
16. Sabol SZ, Hu S, Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet. 1998;103:273-279.
17. Syagailo YV, Stober G, Grassle M, et al. Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders. Am J Med Genet. 2001;105:168-171.
18. Kunugi H, Nanko S, Ueki A, et al. High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease. Neurosci Lett. 1997;221:202-204.
19. Deckert J, Catalano M, Syagailo YV, et al. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet. 1999;8:621-624.
20. Perneger TV. What's wrong with Bonferroni adjustments. BMJ. 1998;316:1236-1238.
21. Nolan KA, Volavka J, Czobor P, et al. Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. Psychiatr Genet. 2000;10:117-124.
22. Li T, Sham PC, Vallada H, et al. Preferential transmission of the high activity allele of COMT in schizophrenia. Psychiatr Genet. 1996;6:131-133.
23. Li T, Ball D, Zhao J, et al. Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11. Mol Psychiatry. 2000;5:452.
24. Herken H, Erdal ME. Catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis. Psychiatr Genet. 2001;11:105-109.
25. Samochowiec J, Lesch KP, Rottmann M, et al. Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism. Psychiatry Res. 1999;86:67-72.
26. Kirov G, Norton N, Jones I, et al. A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder. Int J Neuropsychopharmcol. 1999;2:293-298.
27. Kunugi H, Ishida S, Kato T, et al. A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders. Mol Psychiatry. 1999;4:393-395.
28. Weinshilboum RM. Biochemical genetics of catecholamines in humans. Mayo Clin Proc. 1983;58:319-330.
29. Syvanen AC, Tilgmann C, Rinne J, et al. Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland. Pharmacogenetics. 1997;7:65-71.