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Volumn 88, Issue 9, 2003, Pages 1072-1074

Effects of the MEK inhibitor CI-1040 (PD 184352) on progenitor growth from normal and myelodysplastic marrow

Author keywords

MAPK; MEK inhibitors

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1;

EID: 0141702130     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (5)

References (9)
  • 1
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    • Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells
    • Towatari M, Iida H, Tanimoto M, Iwata H, Hamaguchi M, Saito H. Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells. Leukemia 1997;11:479-84.
    • (1997) Leukemia , vol.11 , pp. 479-484
    • Towatari, M.1    Iida, H.2    Tanimoto, M.3    Iwata, H.4    Hamaguchi, M.5    Saito, H.6
  • 2
    • 0033151533 scopus 로고    scopus 로고
    • Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: Combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase, PAC1
    • Kim SC, Hahn JS, Min YH, Yoo NC, Ko YW, Lee WJ. Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase, PAC1. Blood 1999;93:3893-9.
    • (1999) Blood , vol.93 , pp. 3893-3899
    • Kim, S.C.1    Hahn, J.S.2    Min, Y.H.3    Yoo, N.C.4    Ko, Y.W.5    Lee, W.J.6
  • 3
    • 0034823632 scopus 로고    scopus 로고
    • Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia
    • Milella M, Kornblau SM, Estrov Z, Carter BZ, Lapillonne H, Harris D, et al. Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest 2001;108:851-9.
    • (2001) J Clin Invest , vol.108 , pp. 851-859
    • Milella, M.1    Kornblau, S.M.2    Estrov, Z.3    Carter, B.Z.4    Lapillonne, H.5    Harris, D.6
  • 5
    • 0001100594 scopus 로고    scopus 로고
    • A phase 1 clinical and pharmacokinetic evaluation of the oral MEK inhibitor, CI-1040, administered for 21 consecutive days, repeated every 4 weeks in patients with advanced cancer
    • abstract
    • Lo Russo PM, Adjei AA, Meyer MB, Wozniak A, Gadgeel SM, Hanson LJ, et al. A phase 1 clinical and pharmacokinetic evaluation of the oral MEK inhibitor, CI-1040, administered for 21 consecutive days, repeated every 4 weeks in patients with advanced cancer. Proc Am Soc Clin Oncol 2002;21:81a[abstract].
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Lo Russo, P.M.1    Adjei, A.A.2    Meyer, M.B.3    Wozniak, A.4    Gadgeel, S.M.5    Hanson, L.J.6
  • 7
    • 0036493359 scopus 로고    scopus 로고
    • In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: Evidence for Fas-dependent apoptosis
    • Claessens YE, Bouscary D, Dupont JM, Picard F, Melle J, Gisselbrecht S, et al. In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis. Blood 2002;99:1594-601.
    • (2002) Blood , vol.99 , pp. 1594-1601
    • Claessens, Y.E.1    Bouscary, D.2    Dupont, J.M.3    Picard, F.4    Melle, J.5    Gisselbrecht, S.6
  • 9
    • 0031213615 scopus 로고    scopus 로고
    • Differential regulation of extracellular signal-regulated kinase 1 and 2 activity during 12-O-tetradecanoylphorbol 13-acetate induced differentiation of HL-60 cells
    • Meighan-Mantha RL, Wellstein A, Riegel AT. Differential regulation of extracellular signal-regulated kinase 1 and 2 activity during 12-O-tetradecanoylphorbol 13-acetate induced differentiation of HL-60 cells. Exp Cell Res 1997;234:321-8.
    • (1997) Exp Cell Res , vol.234 , pp. 321-328
    • Meighan-Mantha, R.L.1    Wellstein, A.2    Riegel, A.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.