Aggressive treatment for the fit elderly with non-small-cell lung cancer? Yes!

Journal of Clinical Oncology

Volumn 21, Issue 17, 2003, Pages 3186-3188

  Sequist, Lecia V ^a   Lynch, Thomas J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; ETOPOSIDE; ANTINEOPLASTIC AGENT;

CANCER RADIOTHERAPY; CANCER STAGING; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; EDITORIAL; GERIATRIC PATIENT; HUMAN; LUNG NON SMALL CELL CANCER; MULTIMODALITY CANCER THERAPY; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE; AGED; LUNG TUMOR; METHODOLOGY; NOTE;

AGED; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CISPLATIN; COMBINED MODALITY THERAPY; HUMANS; LUNG NEOPLASMS; RADIOTHERAPY DOSAGE; RANDOMIZED CONTROLLED TRIALS; RESEARCH DESIGN;

EID: 0141688376     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2003.04.002     Document Type: Editorial

References (17)

1. Edwards BK, Howe HL, Ries LAG, et al: Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on the U.S. cancer burden. Cancer 94:2766-2792, 2002
2. Yancik R: Cancer burden in the aged. Cancer 80:1273-1283, 1997
3. Sause W, Kolesar P, Taylor S: Final results of phase III trial in regionally advanced unresectable non-small cell lung cancer. Chest 117:358-364, 2000
4. Furuse K, Fukuoka M, Kawahara M: Phase III study of concurrent versus sequential thoracic RT in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer. J Clin Oncol 17:2692-2699, 1999
5. Dillman RO, Herndon J, Seagren SL, et al: Improved survival in stage III non-small-cell lung cancer: Seven-year follow-up of cancer and leukemia group B (CALGB) 8433 trial. J Natl Cancer Inst 88:1210-1215, 1996
6. Yellen SB, Cella DF, Leslie WT: Age and clinical decision making in oncology patients. J Natl Cancer Inst 86:1766-1770, 1994
7. Schild SE, Stella PJ, Geyer SM, et al: The outcome of combined modality therapy for stage III non-small cell lung cancer (NSCLC) in the elderly. J Clin Oncol 21:3201-3206, 2003
8. Schild SE, Stella PJ, Geyer SM, et al: Phase III trial comparing chemotherapy plus once-daily or twice-daily radiotherapy in stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 54:370-378, 2002
9. Rocha Lima CMS, Herndon JE, Kosty M, et al: Therapy choices among older patients with lung carcinoma: An evaluation of two trials of the cancer and leukemia group B. Cancer 94:181-187, 2002
10. Langer CJ, Hsu C, Curran WJ, et al: Elderly patients (pts) with locally advanced non-small cell lung cancer (LA-NSCLC) benefit from combined modality therapy: Secondary analysis of radiation therapy oncology group (RTOG) 94-10. Presented at the Annual Meeting of the Am Soc Clin Oncol, Orlando, FL, May 18-21, 2002
11. Sargent D, Goldberg R, Jacobson S, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 345:1091-1097, 2001
12. Werner-Wasik M, Scott C, Cox JD: Recursive partitioning analysis of 1999 radiation therapy oncology group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC): Identification of five groups with different survival. Int J Radiat Oncol Biol Phys 48:1475-1482, 2000
13. Movsas B, Scott C, Sause W: The benefit of treatment intensification is age and histology-dependent in patients with locally advanced non-small cell lung cancer (NSCLC): A quality-adjusted survival analysis of radiation therapy oncology group (RTOG) chemoradiation studies. Int J Radiat Oncol Biol Phys 45:1143-1149, 1999
14. Hutchins LF, Unger JM, Crowley JJ, et al: Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 341:2061-2067, 1999
15. Goodwin JS, Hunt WC, Samet JM: Determinants of cancer therapy in elderly patients. Cancer 72:594-601, 1993
16. Goodwin JS, Samet JM, Hunt WC: Determinants of survival in older cancer patients. J Natl Cancer Inst 88:1031-1038, 1996
17. Gridelli C, Perrone F, Gallo C, et al: Chemotherapy for elderly patients with advanced non-small-cell lung cancer: The Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial. J Natl Cancer Inst 95:362-372, 2003 (comment)