A pharmacologically distinct nicotinic ACh receptor is found in a subset of frog semicircular canal hair cells

Journal of Neurophysiology

Volumn 90, Issue 3, 2003, Pages 1526-1536

  Holt, Joseph C ^a,b   Lioudyno, Maria ^a   Guth, Paul S ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM; ACETYLCHOLINE; ATROPINE; CARBACHOL; CHOLINESTERASE INHIBITOR; MUSCARINIC RECEPTOR; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PHYSOSTIGMINE; PROPYLBENZILOYLCHOLINE MUSTARD; STRYCHNINE; TUBOCURARINE CHLORIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; EFFERENT NERVE; FROG; GENE EXPRESSION; HAIR CELL; NERVE STIMULATION; NONHUMAN; PARASYMPATHETIC INNERVATION; PATCH CLAMP; PRIORITY JOURNAL; SEMICIRCULAR CANAL; SENSORY NERVE; VESTIBULAR SYSTEM;

ANIMALS; ANURA; CHOLINERGIC AGONISTS; CHOLINERGIC ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HAIR CELLS; RANA PIPIENS; RECEPTORS, NICOTINIC; SEMICIRCULAR CANALS;

EID: 0141676687     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00273.2002     Document Type: Article

References (42)

1. Anderson AD, Troyanovskaya M, and Wackym PA. Differential expression of alpha2-7, alpha9 and beta2-4 nicotinic acetylcholine receptor subunit mRNA in the vestibular end-organs and Scarpa's ganglia of the rat. Brain Res 778: 409-413, 1997.
2. Art JJ, Fettiplace R, and Fuchs PA. Synaptic hyperpolarization and inhibition of turtle cochlear hair cells. J Physiol 356: 525-550, 1984.
3. Bernard C, Cochran SL, and Precht W. Presynaptic actions of cholinergic agents upon the hair cell-afferent fiber synapse in the vestibular labyrinth of the frog. Brain Res 338: 225-236, 1985.
4. Bobbin RP, Bledsoe SC Jr, Winbery S, Ceasar G, and Jenison GL. Comparative actions of GABA and acetylcholine on the Xenopus laevis lateral line. Comp Biochem Physiol C 80: 313-318, 1985.
5. Brichta AM and Goldberg JM. Responses to efferent activation and excitatory response-intensity relations of turtle posterior-crista afferents. J Neurophysiol 83: 1224-1242, 2000.
6. Corey DP and Hudspeth AJ. Ionic basis of the receptor potential in a vertebrate hair cell. Nature 281: 675-677, 1979.
7. Elgoyhen AB, Vetter DE, Katz E, Rothlin CV, Heinemann SF, and Boulter J. α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc Natl Acad Sci USA 98: 3501-3506, 2001.
8. Erostegui C, Norris CH, and Bobbin RP. In vitro pharmacologic characterization of a cholinergic receptor on outer hair cells. Hear Res 74: 135-147, 1994.
9. Fuchs PA and Murrow BW. Cholinergic inhibition of short (outer) hair cells of the chicks cochlea. J Neurosci 12: 800-809, 1992.
10. Garcia-Colunga J and Miledi R. Modulation of nicotinic acetylcholine receptors by strychnine. Proc Natl Acad Sci USA 96: 4113-4118, 1999.
11. Glowatzki E, Ruppersberg JP, Zenner HP, and Rusch A. Mechanically and ATP-induced currents of mouse outer hair cells are independent and differentially blocked by d-tubocurarine. Neuropharmacology 36: 1269-1275, 1997.
12. Goldberg JM, Brichta AM, and Wackym PA. Neurochemistry of the Vestibular System. Boca Raton, FL: CRC, 2000, p. 61-94.
13. Guth PS, Dunn A, Kronomer K, and Norris CH. The cholinergic pharmacology of the frog saccule. Hear Res 75: 225-232, 1994a.
14. Guth PS, Fermin CD, Pantoja M, Edwards R, and Norris CH. Hair cells of different shapes and their placement along the frog crista ampullaris. Hear Res 73: 109-115, 1994b.
15. Guth PS, Norris CH, Guth SL, Quine DB, and Williams WH. Cholinomimetics mimic efferent effects on semicircular canal afferent activity in the frog. Acta Otolaryngol (Stockh) 102: 194-203, 1986.
16. Guth PS, Perin P, Norris CH, and Valli P. The vestibular hair cells: post transductional signal processing. Prog Neurobiol 54: 193-247, 1998.
17. Haghighi AP and Cooper E. A molecular link between inward rectification and calcium permeability of neuronal nicotinic acetylcholine alpha3beta4 and alpha4beta2 receptors. J Neurosci 20: 529-541, 2000.
18. Holt JC, Lioudyno M, Athas G, Garcia MM, and Guth PS. A third acetylcholine receptor in the vestibular periphery pharmacologically distinct from alpha9-nicotinic and muscarinic acetylcholine receptors. Assoc Res Otolaryngol Abstr 23: 590, 2000.
19. Holt JC, Lioudyno M, Athas G, Garcia MM, Perin P, and Guth PS. The effect of proteolytic enzymes on the alpha9- nicotinic receptor-mediated response in isolated frog vestibular hair cells. Hear Res 152: 25-42, 2001.
20. Honrubia V, Hoffman LF, Sitko S, and Schwartz IR. Anatomic and physiological correlates in bullfrog vestibular nerve. J Neurophysiol 61: 688-701, 1989.
21. Horn R and Marty A. Muscarinic activation of ionic currents measured by a new whole-cell recording method. J Gen Physiol 92: 145-159, 1988.
22. Housley GD, Norris CH, and Guth PS. Cholinergically-induced changes in outward currents in hair cells isolated from the semicircular canal of the frog. Hear Res 43: 121-133, 1990.
23. Lopez I and Meza G. Neurochemical evidence for afferent GABAergic and efferent cholinergic neurotransmission in frog vestibule. Neuroscience 25: 13-18, 1988.
24. Lysakowski A. Synaptic organization of the crista ampullaris. Ann NY Acad Sci 781: 164-182, 1996.
25. Masetto S, Russo G, and Prigioni I. Differential expression of potassium currents by hair cells in thin slices of frog crista ampullaris. J Neurophysiol 72: 443-455, 1994.
26. Myers SF, Salem HH, and Kaltenbach JA. Efferent neurons and vestibular cross talk in the frog. J Neurophysiol 77: 2061-2070, 1997.
27. Nenov AP, Norris CH, and Bobbin RP. Acetylcholine response in guinea pig outer hair cells: I. Properties of the response. Hear Res 101: 132-148, 1996.
28. Norris CH, Housley GD, Williams WH, Guth SL, and Guth PS. The acetylcholine receptors of the semicircular canal in the frog (Rana pipiens). Hear Res 32: 197-206, 1988.
29. Perin P, Holt JC, Guth PS, and Norris CH. A comparison of the cholinergic properties of the leopard frog vestibular organs. Primary Sensory Neuron 2: 275-282, 1998.
30. Perin P, Masetto S, Martini M, Rossi ML, Rubbini G, Rispoli G, Guth P, Zucca Zueea G, and Valli P. Regional distribution of calcium currents in frog semicircular canal hair cells. Hear Res 152: 67-76, 2001.
31. Prigioni I, Russo G, and Marcotti W. Potassium currents of pear-shaped hair cells in relation to their location in frog crista ampullaris. Neuroreport 7: 1841-1845, 1996.
32. Ramcharan EJ and Matthews MR. Autoradiographic localization of functional muscarinic receptors in the rat superior cervical sympathetic ganglion reveals an extensive distribution over non-synaptic surfaces of neuronal somata, dendrites and nerve endings. Neuroscience 7: 797-832, 1996.
33. Rossi ML, Prigioni I, Valli P, and Casella C. Activation of the efferent system in the isolated frog labyrinth: effects on the afferent EPSPs and spike recorded from single fibres of the posterior nerve. Brain Res 185: 125-137, 1980.
34. Rothlin CV, Lioudyno MI, Silbering AF, Plazas PV, Casati ME, Katz E, Guth PS, and Elgoyhen AB. Direct interaction of serotonin type 3 receptor ligands with recombinant and native alpha 9 alpha 10-containing nicotinic cholinergic receptors. Mol Pharmacol 63: 1067-1074, 2003.
35. Sgard F, Charpantier E, Bertrand S, Walker N, Caput D, Graham D, Bertrand D, and Besnard F. A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. Mol Pharmacol 61: 150-159, 2002.
36. Steinacker A and Rojas L. Acetylcholine modulated potassium channel in the hair cell of the toadfish saccule. Hear Res 35: 265-269, 1988.
37. Sugai T, Sugitani M, and Ooyama H. Effects of activation of the divergent efferent fibers on the spontaneous activity of vestibular afferent fibers in the toad. Jpn J Physiol 41: 217-232, 1991.
38. Sugai YJ, Sugitani M and Ooyama H. Actions of cholinergic agonist and antagonists on the efferent synapse in the frog sacculus. Hear Res 61: 56-64, 1992.
39. Valli P, Botta L, Zucca G, and Casella C. Functional organization of the peripheral efferent vestibular system in the frog. Brain Res 362: 92-97, 1986.
40. Valli P, Taglietti V, and Rossi ML. Effects of D-tubocurarine on the ampullar receptors of the frog. Acta Otolaryngol 78: 51-58, 1974.
41. Verbitsky M, Rothlin CV, Katz E, and Elgoyhen AB. Mixed nicotinic-muscarinic properties of the alpha9 nicotinic cholinergic receptor. Neuropharmacology 39: 2515-2524, 2000.
42. Wakade AR and Wakade TD. Contribution of nicotinic and muscarinic receptors in the secretion of catecholamines evoked by endogenous and exogenous acetylcholine. Neuroscience 10: 973-978, 1983.