Specific cleavage sites on human IgG subclasses by cruzipain, the major cysteine proteinase from Trypanosoma cruzi

Molecular and Biochemical Parasitology

Volumn 130, Issue 1, 2003, Pages 23-29

  Berasain, Patricia ^a   Carmona, Carlos ^a   Frangione, Blas ^b   Cazzulo, Juan José ^c   Goñi, Fernando ^b,d  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b NEW YORK UNIVERSITY   (United States)

^c INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

^d UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

Cruzipain; Human IgG subclasses; Trypanosoma cruzi

Indexed keywords

CATHEPSIN B; CATHEPSIN L; CRUZIPAIN; CYSTEINE PROTEINASE; FC RECEPTOR; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4;

ACIDITY; ALKALINITY; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; IMMUNOBLOTTING; IMMUNOCOMPETENT CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0141671823     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(03)00139-7     Document Type: Article

References (32)

1. Cazzulo J.J., Stoka V., Turk V. The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease. Curr. Pharm. Design. 7:2001;1143-1156.
2. Parussini F., Duschak V.G., Cazzulo J.J. Membrane-bound cysteine proteinase isoforms in different developmental stages of Trypanosoma cruzi. Cell Mol. Biol. 44:1998;513-519.
3. Schnapp A.R., Eickhoff C.S., Sizemore D., Curtiss R. III, Hoft D.F. Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice. Infect Immun. 70:2002;5065-5074.
4. Cazzulo J.J. Proteinases of Trypanosoma cruzi: potential Targets for the chemotherapy of Chagas Disease. Curr. Top Med. Chem. 2:2002;1261-1271.
5. Kierszenbaum F., Ramirez M.A. Modulation of sensitivity of blood forms of Trypanosoma cruzi to antibody-mediated, complement-dependent lysis. Infect. Immun. 58:1990;119-123.
6. Takehara H.A., Perini A., Silva M.A., Mota I. Trypanosoma cruzi: role of different antibody classes in protection against infection in the mouse. Exp. Parasitol. 52:1981;137-146.
7. Araujo F.G., Heilman B., Tighe L. Antigens of Trypanosoma cruzi detected by different classes and subclasses of antibodies. Trans. Royal Soc. Trop. Med. Hygiene. 78:1984;672-677.
8. Martinez J., Campetella O., Frasch A.C.C., Cazzulo J.J. The reactivity of sera from chagasic patients against different fragments of cruzipain, the major cysteine proteinase from Trypanosoma cruzi, suggests the presence of defined antigenic and catalytic domains. Immunol. Lett. 35:1993;191-196.
9. Drumond F., Assis O., Da Costa M.O., Jorge S., Correa-Oliveira R., Romanha A.J. Anti-Trypanosoma cruzi immunoglobulin G1 can be useful tool for diagnosis and Prognosis of human Chagas' disease. Clin. Diag. Lab. Immunol. 8:2001;112-118.
10. Teixeira A.R.L., Santana J.M. Trypanosoma cruzi: endocytosis and degradation of specific antibodies by parasite forms. Am. J. Trop. Med. Hyg. 40:1989;165-170.
11. Bontempi E., Cazzulo J.J. Digestion of human immunoglobulin G by the major cysteine proteinase (cruzipain) from Trypanosoma cruzi. FEMS Microbiol. Lett. 70:1990;337-342.
12. Labriola C., Sousa M., Cazzulo J.J. Purification of the major cysteine proteinase (cruzipain) from Trypanosoma cruzi by affinity chromatography. Biological. Res. 26:1993;101-107.
13. Redinbaugh M.G., Turley R.B. Adaptation of the bicinchoninic acid protein assay for use with microtiter plates and sucrose gradient fractions. Anal. Biochem. 153:1986;267-271.
14. Berasain P., Carmona C., Frangione B., Dalton J.P., Goñi F. Fasciola hepatica: parasite-secreted proteinases degrade all human IgG subclasses. Determination of the specific cleavage sites and identification of the immunoglobulin fragments produced. Exp. Parasitol. 94:2000;99-110.
15. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 76:1979;4350-4354.
16. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C. Sequences of proteins of immunological interest. 5th ed. NIH publication no. 91,1991.
17. Brekke O.H., Michaelsen T.E., Sandlie I. The structural requirements for complement activation by IgG: does it hinge on the hinge? Immunol. Today. 16:1995;85-89.
18. Klemba M., Goldberg D.E. Biological roles of proteases in parasitic protozoa. Annu. Rev. Biochem. 71:2002;275-305.
19. Scharfstein J., Schechter M., Senna M., Peralta J.M., Mendonça-Previato L., Miles M.M. Trypanosoma cruzi: characterization and isolation of a 57/51,000 m.w. surface glycoprotein (GP57/51) expressed by epimastigotes and blood-stream trypomastigotes. J. Immunol. 137:1986;1336-1341.
20. Martinez J., Campetella O., Frasch A.C.C., Cazzulo J.J. The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections. Inf. Immun. 59:1991;4275-4277.
21. Kretti A, Thomas N, Eisen H. Escapes mechanisms of Trypanosoma cruzi from the immune host system. In: Israel L, Lagrange P, Salomon JC, editors. Les Colloquies de I'INSERM. Cancer Immunology and Parasite Immunology, Paris: INSERM, 1980;97:553.
22. Kierszenbaum F., Hayes M.M. Mechanisms of resistance against experimental Trypanosoma cruzi infection. Requirements for cellular destruction of circulating forms of T. cruzi in human and murine in vitro systems. Immunology. 40:1980;61-66.
23. Cardoni R.L., Rimoldi M.T., de Bracco M.M. Antibody-dependent cytotoxicity of human and mouse mononuclear cells against Trypanosoma cruzi epimastigotes. Cell Immunol. 86:1984;518-524.
24. Michaelsen TE. Fragmentation and conformational changes of IgG subclasses. In: Shakib F, editor. The human IgG subclasses. Pergamon Press, UK, 1990;31.
25. Barret A.J., Kirschke H. Cathepsin B, cathepsin H and cathepsin L. Methods Enzymol. 80(Pt C):1981;535-561.
26. Gillmor S.A., Craik C.S., Fletterick R.J. Structural determinants of specificity in the cysteine protease cruzain. Prot. Sci. 6:1997;1603-1611.
27. Del Nery E., Juliano M.A., Mendal M., Svedsen I., Scharfstein J., Walmsley A.et al. Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides. Biochem. J. 323:1997;427-433.
28. Chagas J.R., Authie E., Serveau C., Lalmanach G., Juliano L., Gauthier F. A comparison of the enzymatic properties of the major cysteine proteinases from Trypanosoma congolense and Trypanosoma cruzi. Mol. Biochem. Parasitol. 88:1997;85-94.
29. Cazzulo J.J., Cazzulo Franke M.C., Martinez J., Franke de Cazzulo B.M. Some kinetic properties of a cysteine proteinase (cruzipain) from Trypanosoma cruzi. Biochim. Biophys. Acta. 1037:1990;186-191.
30. Raimondi A., Wernstedt C., Hellman U., Cazzulo J.J. Degradation of oxidized insulin A and B chains by the major cysteine proteinase (cruzipain) from Trypanosoma cruzi epimastigotes. Mol. Biochem. Parasitol. 49:1991;341-344.
31. Cicarelli R.M.B., Lopes J.D. Characterization of a protein from Trypanosoma cruzi trypomastigotes that cleaves non-immune IgG bound to its Fab fragment. J. Immunol. 142:1989;1685-1690.
32. Yokoyama-Yasunaka J.K.U., Pral E.M.F., Oliveira O.C. Jr., Alfieri S.C., Stolf A.M.S. Trypanosoma cruzi: identification of proteinases in shed components of trypomastigote forms. Acta Tropica. 57:1994;307-315.