Pathogenesis and treatment of extranodal lymphomas: The fascinating model of mucosa-associated lymphoid tissue lymphoma

Haematologica

Volumn 88, Issue 8, 2003, Pages 841-844

  Zucca, Emanuele ^a   Bertoni, Francesco ^a,b   Cavalli, Franco ^a  

^a ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMBUCIL; CLADRIBINE; CYCLOPHOSPHAMIDE; RITUXIMAB;

ADJUVANT CHEMOTHERAPY; APOPTOSIS; BLAST CELL; CANCER LOCALIZATION; CELL CULTURE; CELL DIFFERENTIATION; CELL TRANSFORMATION; CHROMOSOME 18Q; CHROMOSOME 18Q21; CHROMOSOME 21; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CLINICAL FEATURE; CLINICAL TRIAL; CLONAL VARIATION; CLONE; DEREGULATION; DISEASE ASSOCIATION; DISEASE MODEL; DRUG EFFICACY; ECHOGRAPHY; EDITORIAL; GASTRITIS; GENE EXPRESSION; GENE MUTATION; GENE TRANSLOCATION; GERM LINE; HASHIMOTO DISEASE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOLOGY; HUMAN; IMMUNE RESPONSE; IMMUNOGLOBULIN GENE; LYMPHOCYTE; MOLECULAR BIOLOGY; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; NODULAR LYMPHOMATOSIS; NONHODGKIN LYMPHOMA; OLIGOMERIZATION; PLASMA; POLYMERASE CHAIN REACTION; PROGNOSIS; PROTEIN EXPRESSION; RANDOMIZATION; SEQUENCE ANALYSIS; SJOEGREN SYNDROME; SOMATIC MUTATION; STOMACH; STOMACH LYMPHOMA; SURGERY; SURVIVAL RATE; T LYMPHOCYTE; TREATMENT FAILURE; TUMOR GROWTH; WILD TYPE;

ANTI-BACTERIAL AGENTS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TISSUE; MODELS, GENETIC; MODELS, IMMUNOLOGICAL;

EID: 0141649450     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (49)

1. Zucca E, Bertoni F, Roggero E, Cavalli F. The gastric marginal zone B-cell lymphoma of MALT type. Blood 2000; 96: 410-9.
2. Cavalli F, Isaacson PG, Gascoyne RD, Zucca E. MALT Lymphomas. Hematology (Am Soc Hematol Educ Program. 2001; 241-58.
3. Du MQ, Isaacson PG. Gastric MALT lymphoma from aetiology to treatment. Lancet Oncol 2002;3:97-104.
4. Isaacson PG, Müller-Hermelink HK, Piris MA. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In: Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. IARC Press, Lyon; 2001. p.157-60.
5. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Isaacson PG. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 1991;338:1175-6.
6. Parsonnet J, Hansen S, Rodriguez L, Gelb AB, Warnke RA, Jellum E, et al. Helicobacter pylori infection and gastric lymphoma. N Engl J Med 1994;330:1267-71.
7. Zucca E, Bertoni F, Roggero E, Bosshard G, Cazzaniga G, Pedrinis E, et al. Molecular analysis of the progression from Helicobacter pylori-associated chronic gastritis to mucosa-associated lymphoid-tissue lymphoma of the stomach. N Engl J Med 1998;338:804-10.
8. Roggero E, Zucca E, Pinotti G, Pascarella A, Capella C, Savio A, et al. Eradication of Helicobacter pylori infection in primary low-grade gastric lymphoma of mucosa-associated lymphoid tissue. Ann Intern Med 1995;122:767-9.
9. Zucca E, Bertoni F, Roggero E, Cazzaniga G, Bosshard G, Biondi A, et al. Autoreactive B cell clones in marginal-zone B cell lymphoma (MALT lymphoma) of the stomach. Leukemia 1998;12:247-9.
10. Qin Y, Greiner A, Trunk MJ, Schmausser B, Ott MM, Muller-Hermelink HK. Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B-cell lymphoma. Blood 1995;86:3528-34.
11. Du M, Diss TC, Xu C, Peng H, Isaacson PG, Pan L. Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion. Leukemia 1996;10:1190-7.
12. Bertoni F, Cazzaniga G, Bosshard G, Roggero E, Barbazza R, De Boni M, et al. Immunoglobulin heavy chain diversity genes rearrangement pattern indicates that MALT-type gastric lymphoma B cells have undergone an antigen selection process. Br J Haematol 1997;97:830-6.
13. Rosenwald A, Ott G, Stilgenbauer S, Kalla J, Bredt M, Katzenberger T, et al. Exclusive detection of the t(11;18) (q21;q21) in extranodal marginal zone B cell lymphomas (MZBL) of MALT type in contrast to other MZBL and extranodal large B cell lymphomas. Am J Pathol 1999;155:1817-21.
14. Auer IA, Gascoyne RD, Connors JM, Cotter FE, Greiner TC, Sanger WG, et al. t(11;18)(q21;q21) is the most common translocation in MALT lymphomas. Ann Oncol 1997;8:979-85.
15. Dierlamm J, Baens M, Wlodarska I, Stefanova-Ouzounova M, Hernandez JM, Hossfeld DK, et al. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18) (q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 1999;93: 3601-9.
16. Remstein ED, James CD, Kurtin PJ. Incidence and subtype specificity of API2-MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas. Am J Pathol 2000;156:1183-8.
17. Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 1999; 96:35-45.
18. Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, Xue L, et al. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nat Genet 1999;22:63-8.
19. Ye H, Dogan A, Karran L, Willis TG, Chen L, Wlodarska, et al. BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. Am J Pathol 2000; 157:1147-54.
20. Liu H, Ye H, Dogan A, Ranaldi R, Hamoudi RA, Bearzi I, et al. T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10. Blood 2001;98:1182-7.
21. Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, et al. Identification of paracaspases and meta-caspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell 2000; 6:961-7.
22. Lucas PC, Yonezumi M, Inohara N, McAllister-Lucas LM, Abazeed ME, Chen FF, et al. Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-k B signaling pathway. J Biol Chem 2001;276:19012-9.
23. McAllister-Lucas LM, Inohara N, Lucas PC, Ruland J, Benito A, Li Q, et al. Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-k B induction. J Biol Chem 2001;276:30589-97.
24. Muto A, Ruland J, McAllister-Lucas LM, Lucas PC, Yamaoka S, Chen FF, et al. Protein Kinase C-associated Kinase (PKK) Mediates Bcl10-independent NF-k B Activation Induced by Phorbol Ester. J Biol Chem 2002;277:31871-6.
25. Liu H, Ruskoné-Fourmestraux A, Lavergne-Slove A, Ye H, Molina T, Bouhnik Y, et al. Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Lancet 2001;357: 39-40.
26. Sanchez-Izquierdo D, Buchonnet G, Siebert R, et al. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Blood 2003 (in press).
27. Streubel B, Lamprecht A, Dierlamm J, Cerroni L, Stolte M, Ott G, et al. T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Blood 2003;101:2335-9.
28. Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, et al. Regression of primary low-grade B-cell gastric lym-phoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 1993;342: 575-7.
29. Pinotti G, Zucca E, Roggero E, Pascarella A, Bertoni F, Savio A, et al. Clinical features, treatment and outcome in a series of 93 patients with low-grade gastric MALT lymphoma. Leuk Lymphoma 1997;26:527-37.
30. Neubauer A, Thiede C, Morgner A, Alpen B, Ritter M, Neubauer B, et al. Cure of Helicobacter pylori infection and duration of remission of low-grade gastric mucosa-associated lymphoid tissue lymphoma. J Natl Cancer Inst 1997;89: 1350-5.
31. Nobre-Leitao C, Lage P, Cravo M, Cabecadas J, Chaves P, Alberto-Santos A, et al. Treatment of gastric MALT lymphoma by Helicobacter pylori eradication: a study controlled by endoscopic ultrasonography. Am J Gastroenterol 1998;93: 732-6.
32. Ruskone-Fourmestraux A, Lavergne A, Aegerter PH, Megraud F, Palazzo L, de Mascarel A, et al. Predictive factors for regression of gastric MALT lymphoma after anti-Helicobacter pylori treatment. Gut 2001;48:297-303.
33. Nakamura S, Matsumoto T, Suekane H, Takeshita M, Hizawa K, Kawasaki M, et al. Predictive value of endoscopic ultrasonography for regression of gastric low-grade and high-grade MALT lymphomas after eradication of Helicobacter pylori. Gut 2001;48:454-60.
34. Steinbach G, Ford R, Glober G, Sample D, Hagemeister FB, Lynch PM, et al. Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue: an uncontrolled trial. Ann Intern Med 1999;131:88-95.
35. Montalban C, Santon A, Boixeda D, Redondo C, Alvarez I, Calleja JL, et al. Treatment of low grade gastric mucosa-associated lymphoid tissue lymphoma in stage I with Helicobacter pylori eradication. Long-term results after sequential histologic and molecular follow-up. Haematologica 2001;86:609-17.
36. Zucca E, Roggero E, Traulle C. Early interim report of the LY03 randomised cooperative trial of observation vs chlorambucil after anti Helicobacter therapy in low-grade gastric lymphoma. Ann Oncol 1999;10 Suppl 3:25.
37. Levy M, Copie-Bergman C, Traulle C, Lavergne-Slove A, Brousse N, Flejou JF, et al. Conservative treatment of primary gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue: predictive factors of response and outcome. Am J Gastroenterol 2002;97:292-7.
38. Bertoni F, Conconi A, Capella C, Motta T, Giardini R, Ponzoni M, et al. Molecular follow-up in gastric mucosa-associated lymphoid tissue lymphomas: early analysis of the LY03 cooperative trial. Blood 2002;99:2541-4.
39. Thiede C, Wundisch T, Alpen B, Neubauer B, Morgner A, Schmitz M, et al. Persistence of monoclonal B cells after cure of Helicobacter pylori infection and complete histologic remission in gastric mucosa-associated lymphoid tissue B-cell lymphoma. German MALT Lymphoma Study Group. J Clin Oncol 2001;19:1600-9.
40. Cogliatti SB, Schmid U, Schumacher U, Eckert F, Hansmann ML, Hedderich J, et al. Primary B-cell gastric lymphoma: a clinicopathological study of 145 patients. Gastroenterology 1991;101:1159-70.
41. Schechter NR, Portlock CS, Yahalom J. Treatment of mucosa-associated lymphoid tissue lymphoma of the stomach with radiation alone. J Clin Oncol 1998;16:1916-21.
42. Tsang RW, Gospodarowicz MK, Pintilie M, Bezjak A, Wells W, Hodgson DC, et al. Stage I and II MALT lymphoma: results of treatment with radiotherapy. Int J Radiat Oncol Biol Phys 2001;50:1258-64.
43. Hitchcock S, Ng AK, Fisher DC, Silver B, Bernardo MP, Dorfman DM, et al. Treatment outcome of mucosa-associated lymphoid tissue/marginal zone non-Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys 2002;52:1058-66.
44. Fung CY, Grossbard ML, Linggood RM, Younger J, Flieder A, Harris NL, et al. Mucosa-associated lymphoid tissue lymphoma of the stomach: long term outcome after local treatment. Cancer 1999;85:9-17.
45. Gospodarowicz MK, Pintilie M, Tsang R, Patterson B, Bezjak A, Wells W. Primary gastric lymphoma: brief overview of the recent Princess Margaret Hospital experience. Recent Results Cancer Res 2000;156:108-15.
46. Hammel P, Haioun C, Chaumette MT, Gaulard P, Divine M, Reyes F, et al. Efficacy of single-agent chemotherapy in low-grade B-cell mucosa-associated lymphoid tissue lymphoma with prominent gastric expression. J Clin Oncol 1995;13: 2524-9.
47. Conconi A, Thieblemont C, Martinelli G. IELSG phase II study of Rituximab in MALT lymphoma: final results. Proc Am Soc Clin Oncol 2002;21:267a [abstract 1067].
48. Jager G, Neumeister P, Brezinschek R, Hinterleitner T, Fiebiger W, Penz M, et al. Treatment of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type with cladribine: a phase II study. J Clin Oncol 2002;20:3872-7.
49. Zucca E, Conconi A, Pedrinis E, Cortelazzo S, Motta T, Gospodarowicz MK, et al. Non-gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Blood 2003; 101:2489-95.