Mononucleoside SATE glucosyl phosphorothiolates as a new series of pronucleotides

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 899-901

  Jochum, A ^a   Schlienger, N ^a   Gosselin, G ^a   Imbach, J L ^a   Aubertin, A M ^b   Perigaud C ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Glucosidase; Mononucleotide; Prodrug

Indexed keywords

ESTERASE; GLUCOSIDASE; GLUCOSYLPHOSPHOROTHIOLATE DERIVATIVE; MONONUCLEOSIDE; NUCLEOSIDE DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PHOSPHOROTHIOIC ACID DERIVATIVE; PRODRUG; TERT BUTYL S PIVALOYL 2 THIOETHYL DERIVATIVE; THIOL DERIVATIVE; THYMIDINE KINASE; UNCLASSIFIED DRUG; ZIDOVUDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DECOMPOSITION; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; VIRUS REPLICATION;

ANTIVIRAL AGENTS; MOLECULAR STRUCTURE; NUCLEOSIDES; PRODRUGS; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0141648319     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022681     Document Type: Conference Paper

References (2)

1. Schlienger, N.; Peyrottes, S.; Kassem, T.; Imbach, J.-L.; Gosselin, G.; Aubertin, A.-M.; Périgaud, C. S-Acyl-2-thioethyl aryl phosphotriester derivatives as mononucleotide prodrugs. J. Med. Chem. 2000, 43, 4570-4574.
2. Egron, D.; Périgaud, C.; Gosselin, G.; Aubertin, A.-M.; Imbach, J.-L. Synthesis and study of a new series of phosphoramidate derivatives as mononucleotide prodrugs. Nucleosides, Nucleotides & Nucleic Acids 2001, 20, 751-754.