Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury

Annals of Neurology

Volumn 54, Issue 4, 2003, Pages 534-539

  Schmitt, Andreas B ^a   Breuer, Sebastian ^a   Polat, Leyla ^a   Pech, Katrin ^a   Kakulas, Byran ^b   Love, Seth ^c   Martin, Didier ^d   Schoenen, Jean ^d   Noth, Johannes ^a   Brook, Gary A ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b Royal Melbourne Hospital   (Australia)

^c FRENCHAY HOSPITAL   (United Kingdom)

^d UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROMODULIN; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CLARKE NUCLEUS NEURON; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NERVE FIBER REGENERATION; NERVE FIBER TRANSECTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPINAL CORD INJURY; SPINAL CORD NERVE CELL; UPREGULATION;

CASPASE 3; CASPASES; GAP-43 PROTEIN; GENES, JUN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NERVE REGENERATION; NEUROFILAMENT PROTEINS; NEURONS; POLYMERASE CHAIN REACTION; RNA PROBES; RNA, MESSENGER; SPINAL CORD INJURIES; TIME FACTORS;

EID: 0141646597     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.10724     Document Type: Article

References (18)

1. Schwab ME, Bartholdy D. Degeneration and regeneration of axons in the lesioned spinal cord. Physiol Rev 1996;76: 319-370.
2. Fawcett JW, Asher RA. The glial scar and central nervous system barrier. Brain Res Bull 1999;49:377-391.
3. Schwab ME. Repairing the injured spinal cord. Science 2002; 295:1029-1031.
4. Skene JHP. Growth-associated proteins and the curious dichotomies of nerve regeneration. Cell 1984;37:697-700.
5. Herdegen T, Skene P, Bähr M. The c-Jun transcription factor-bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci 1997;20:227-231.
6. Schmitt AB, Breuer S, Voell M, et al. GAP-43 (B-50) and C-Jun are up-regulated in axotomized neurons of Clarke's nucleus after spinal cord injury in the adult rat. Neurobiol Dis 1999;6:122-130.
7. Brook GA, Schmitt AB, Nacimiento W, et al. distribution of B-50 (GAP-43) mRNA and protein in the normal adult human spinal cord. Acta Neuropathol 1998;95:378-386.
8. Levey AI, Bolam JP, Rye DB, et al. A light and electron microscopic procedure for sequential double antigen localization using diaminobenzidine and benzidine dihydrochloride. J Histochem Cytochem 1986;34:1449-1457.
9. Duan WR, Garner DS, Williams SD, et al. Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts. J Pathol 2003;199:221-228.
10. Martin JE, Mather KS, Swash M, et al. Spinal cord trauma in man: studies of phosphorylated neurofilament and ubiquitin expression. Brain 1990;82:802-812.
11. Kawamura Y, Dyck PJ. Permanent axotomy by amputation results in loss of motor neurons in man. J Neuropathol Exp Neurol 1981;40:658-666.
12. Jenkins R, Tetzlaff W, Hunt SP. Differential expression of immediate early genes in rubrospinal neurons following axotomy in rat. Eur J Neurosci 1993;5:203-209.
13. Tetzlaff W, Alexander SW, Miller FD, et al. Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43. J Neurosci 1991;11: 2528-2544.
14. Tetzlaff W, Kobayashi NR, Giehl KMG, et al. Response of rubrospinal and corticospinal neurons to injury and neurotrophins. Prog Brain Res 1994;103:271-286.
15. Sanner CA, Cunningham TJ, Goldberger ME. NMDA receptor blockade rescues Clarke's and red nucleus neurons after spinal hemisection. J Neurosci 1994;14:6472-6480.
16. Curtis R, Green D, Lindsay RM, et al. Up-regulation of GAP-43 and growth of axons in rat spinal cord after compression injury. J Neurocytol 1993;22:51-64.
17. Brook GA, Plate D, Franzen R, et al. Spontaneous longitudinally orientated axonal regeneration is associated with the Schwann cell framework within the lesion site following spinal cord compression injury of the rat. J Neurosci Res 1998;53:51-65.
18. Goldstein ME, Cooper HS, Bruce J, et al. Phosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve. J Neurosci 1987;7:1586-1594.