Transition metal free reductive dimerization of nitrogen containing barbituric acid benzylidenes

Journal of Heterocyclic Chemistry

Volumn 40, Issue 4, 2003, Pages 701-706

  Jursic, Branko S ^a   Stevens, Edwin D ^a  

^a UNIVERSITY OF NEW ORLEANS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CARBOXALDEHYDE DERIVATIVE; ALDEHYDE DERIVATIVE; BARBITURIC ACID BENZYLIDENE DERIVATIVE; BARBITURIC ACID DERIVATIVE; HETEROCYCLIC COMPOUND; METAL; NITROGEN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; DIMERIZATION; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REDUCTION; STRUCTURE ANALYSIS; X RAY ANALYSIS;

EID: 0141619306     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570400423     Document Type: Article

References (18)

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10. Biological activity was evaluated by NIH (division of treatment research & development, NIDA/NIH).
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14. All NMR reaction monitoring was performed on VARIAN UNITY 500 operating 500 MHz with solvent signal as an internal standard starting with heterocyclic carboxaldehyde concentration to be 1 M.
15. Although preparation of the reductive dimer of barbituric acid benzylidenes with both 2-pyridine and 2-quinoline moieties are synthetically excellent procedures the reductive dimerization product was not detected if nitrogen was in any other position of the aromatic ring or if benzene, naphthalene and antracene were used instead of pyridine and quinoline rings. At the present moment we do not have an explanation for these differences in the reactivity.
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