Characterization of a fully human IgG1 reconstructed from an anti-AChR Fab

Annals of the New York Academy of Sciences

Volumn 998, Issue , 2003, Pages 399-400

  Stassen, Maurice H W ^a   Machiels, Barbie M ^a   Fostieri, Efrosini ^b   Tzartos, Socrates J ^b   Berrih Aknin, Sonia ^c   Bosmans, Eugène ^d   Parren, Paul W H I ^e   De Baets, Marc H ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b HELLENIC PASTEUR INSTITUTE   (Greece)

^c CENTRE CHIRURGICAL MARIE LANNELONGUE   (France)

^d DiaMed EuroGen   (Belgium)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Acetylcholine receptor; Antigenic modulation; F ab; IgG1; Myasthenia gravis

Indexed keywords

CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN LIGHT CHAIN; PEPTIDE DERIVATIVE; PROTEIN G;

ANTIGEN ANTIBODY COMPLEX; ANTIGENICITY; BINDING AFFINITY; CHO CELL; CISTRON; CONFERENCE PAPER; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOLECULAR CLONING; MYASTHENIA GRAVIS; NONHUMAN; PATHOGENICITY; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIOIMMUNOASSAY;

EID: 0141615808     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1254.050     Document Type: Conference Paper

References (4)

1. GRAUS, Y.F., M.H. DE BAETS, P.W. PARREN et al. 1997. Human anti-nicotinic acetylcholine receptor recombinant Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies. J. Immunol. 158: 1919-1929.
2. MENG, F., M.H.W. STASSEN, S. SCHILLBERG et al. 2002. Construction and characterization of a single-chain antibody fragment derived from thymus of a patient with myasthenia gravis. Autoimmunity 35: 125-133.
3. TOYKA, K.V., B. LOWENADLER, K. HEININGER et al. 1980. Passively transferred myasthenia gravis: protection of mouse endplates by Fab fragments from human myasthenic IgG. J. Neurol. Neurosurg. Psychiatry 43: 836-840.
4. PAPANASTASIOU, D., K. POULAS, A. KOKLA & S.J. TZARTOS. 2000. Prevention of passively transferred experimental autoimmune myasthenia gravis by Fab fragments of monoclonal antibodies directed against the main immunogenic region of the acetylcholine receptor. J. Neuroimmunol. 104: 124-132.