Triplex formation involving 2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA) with 2-pyridone base analogue: Efficient and selective recognition of C:G interruption

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 1097-1099

  Torigoe, Hidetaka ^a   Hari, Yoshiyuki ^b   Obika, Satoshi ^b   Imanishi, Takeshi ^b  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

2 Pyridone; Triplex, 2 O,4 C Methylene bridged nucleic acid

Indexed keywords

2 PYRIDONE DERIVATIVE; 2' O,4' C METHYLENE BRIDGED NUCLEIC ACID; CYTOSINE; DOUBLE STRANDED DNA; GUANINE; NUCLEIC ACID; NUCLEIC ACID BASE; UNCLASSIFIED DRUG;

BINDING AFFINITY; COMPLEX FORMATION; CONFERENCE PAPER; DNA SEQUENCE; THERMODYNAMICS;

BASE PAIRING; BASE SEQUENCE; BINDING SITES; CYTOSINE; GUANINE; HYDROCARBONS; METHANE; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; THERMODYNAMICS;

EID: 0141596281     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022745     Document Type: Conference Paper

References (6)

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2. 3′-endo sugar puckering. Tetrahedron Lett. 1997, 38, 8735-8738.
3. Obika, S.; Hari, Y.; Sekiguchi, M.; Imanishi, T. A 2′,4′ -bridged nucleic acid containing 2-pyridone as a nucleobase: Efficient recognition of a C·G interruption by triplex formation with a pyrimidine motif. Angew. Chem. Int. Ed. Engl. 2001, 40, 2079-2081.
4. Torigoe, H.; Hari, Y.; Sekiguchi, M.; Obika, S.; Imanishi, T. 2′-O,4′-C-methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH. J. Biol. Chem. 2001, 276, 2354-2360.
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