The impact of genes and pre- and postnatal environment on the metabolic syndrome. Evidence from twin studies

Panminerva Medica

Volumn 45, Issue 2, 2003, Pages 109-115

  Poulsen, P ^a   Vaag, A ^b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b STENO DIABETES CENTER   (Denmark)

Author keywords

Hyperinsulinemia; Insulin resistance, diagnosis; Insulin resistance, genetics

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

CHOLESTEROL BLOOD LEVEL; DIABETIC OBESITY; DIZYGOTIC TWINS; GLUCOSE INTOLERANCE; GLUCOSE TRANSPORT; HUMAN; LIPOPROTEIN BLOOD LEVEL; METABOLIC SYNDROME X; MONOZYGOTIC TWINS; ORAL GLUCOSE TOLERANCE TEST; PERINATAL PERIOD; REVIEW; TRIACYLGLYCEROL BLOOD LEVEL; BIOLOGICAL MODEL; ENVIRONMENT; GENETICS; NEWBORN; PRENATAL DEVELOPMENT; TWINS;

DISEASES IN TWINS; ENVIRONMENT; HUMANS; INFANT, NEWBORN; METABOLIC SYNDROME X; MODELS, BIOLOGICAL; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 0141595931     PISSN: 00310808     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. Modan M, Halkin H, Almog S, Lusky A, Eshkol A, Shefi M et al. Hyperinsulinemia. A link between hypertension obesity and glucose intlerance. J Clin Invest 1985;75(3):809-17.
2. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988;37:1595-607.
3. Ferrannini E, Buzzigoli G, Bonadonna R, Giorico MA, Oleggini M, Graziadei L et al. Insulin resistance in essential hypertension. N Engl J Med 1987;317(6):350-7.
4. Ferrannini E, Haffner SM, Mitchell BD, Stern MP. Hyperinsulinemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia 1991;34:416-22.
5. DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes Care 1991;14:173-194.
6. Meigs JB, D'Agostino RB, Wilson PWF, Cupples LA, Nathan DM, Singer DE. Risk variable clustering in the insulin resistance syndrome. Diabetes 1997;46:1594-600.
7. Sadler TW. Fetal membranes and placenta. In: Langman's Medical Embryology. Baltimore, Philidelphia, Hong Kong, London, Munich, Sydney, Tokyo: Williams & Wilkins; 1995.p.101-21.
8. Bjõro K jr, Bjõro K. Disturbed intrauterine growth in twins: etiological aspects. Acta Genet Med Gemellol 1985;34:73-9.
9. Ramas-Arroyo MA, Ulbright TM, Yu PL, Christian JC. Twin study: relationship between birth weight, zygosity, placentation and pathologic placental changes. Acta Genet Med Gemellol 1988;37:229-38.
10. Naeye RL, Benirschke K, Hagstrom JWC, Marcus CC. Intrauterine growth of twins as estimated from liveborn birth weight data. Pediatrics 1966;37:409-16.
11. Harvald B, Hauge M. Hereditary factors elucidated by twin studies. In: Neel JV, Shaw MW, Schull WJ, editors. Genetics and the epidemiology of chronic diseases. Washington DC, US: Department of Health, Education and Welfare, Public Health Service Publication; 1965;1163.p.61-76.
12. Gedda L. World Health Organisation. The use of twins in epidemiological studies. Report of the WHO meeting of investigators on methodology of twin studies. Acta Genet Med Gemellol Roma 1966;15:109-28.
13. Allen G, Harvald B, Shields J. Measures of twin concordance. Acta Gen Stat Med 1967;17:475-81.
14. McGue M. When assessing twin concordance, use the probandwise not the pairwise rate. Schizophr Bull 1992;18:171-6.
15. Neale MC, Cardon LR. Data summary. In: Methodology for genetic studies of twins and families. Dordrecht, Boston, London: Kluwer Academic Publishers, NATO ASI series, 1967:35-53.
16. Poulsen P, Vaag A, Kyvik K, Beck-Nielsen H. Genetic versus environmental aetiology of the metabolic syndrome among male and female twins. Diabetologia 2002;44:537-43.
17. Beck-Nielsen H, Groop L. Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus. J Clin Invest 1994;94:1714-21.
18. Hales CN, Barker DJP, Clark PMS, Cox LJ, Fall C, Osmond C et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 1991;303:1019-22.
19. Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992;35: 595-601.
20. Barker DJP, Bull AR, Osmond C, Simmonds SJ. Fetal and placental size and risk of hypertension in adult life. BMJ 1990;301:259-62.
21. Barker DJP, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS. Fetal nutrition and cardiovascular disease in adult life. Lancet 1993;341:938-41.
22. Leon DA, Koupilova I, Lithell HO, Berglund L, Mohsen R, Vågerö D et al. Failure to realise growth potential in utero and adult obesity in relation to blood pressure in 50 year old Swedish men. BMJ 1996;312:401-6.
23. Leon DA, Lithell HO, Vågerö D, Koupilova I, Mohsen R, Berglund L et al. Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15000 Swedish men and women born 1915-29. BMJ 1998;317:241-5.
24. Lithell HO, McKeigue PM, Berglund L, Mohsen R, Lithell U-B, Leon DA. Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years. BMJ 1996;312: 406-10.
25. Poulsen P, Vaag AA, Kyvik KO, Jensen DM, Beck-Nielsen H. Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs. Diabetologia 1997;40:439-46.
26. Barker DJ, Martyn CN, Osmond C, Hales CN, Fall CH. Growth in utero and serum cholesterol concentrations in adult life. BMJ 1994;308:1524-7.
27. Phillips DIW, McLeish R, Osmond C, Hales CN. Fetal growth and insulin resistance in adult life: role of plasma triglyceride and non-estified fatty acids. Diabetic Med 1995;12:796-801.
28. Donker GA, Labarthe DR, Harrist RB, Selwyn BJ, Srinivasan SR, Wattigney W et al. Low birth weight and serum lipid concentrations at age 7-11 years in a biracial sample. Am J Epidemiol 1997;145(5): 398-407.
29. Poulsen P, Vaag A, Beck-Nielsen H. Does zygosity status influence the metabolic profile in twins? A population-based twin study. BMJ 1999;319:151-4.
30. Poulsen P, Levin K, Vaag A, Beck-Nielsen H. The impact of zygosity and age on in vivo insulin action. Diabetes Res Clin Practice 1999;50 Suppl 1:S101.
31. Hattersley AT, Tooke JE. The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease. Lancet 1999;353:1789-92.
32. Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen. Heritability of non-insulin-dependent diabetes mellitus (NIDDM) and abnormal glucose tolerance - A population-based twin study. Diabetologia 1999;42:139-45.
33. Poulsen P, Vaag A, Beck-Nielsen H. The influence of zygosity status on blood pressure and on lipid profiles in male and female twins. J Hypertension 2002, in press.
34. Lehtovirta M, Kaprio J, Forsblom C, Eriksson J, Tuomilehto J, Groop L. Insulin and insulin secretion in monozygotic and dizygotic twins. Diabetologia 2000;43:285-93.
35. Baird J, Osmond C, MacGregor A, Snieder H, Hales CN, Phillips DIW. Testing the fetal origins hypothesis in twins: the Birmingham twin study. Diabetologia 2001;44:33-9.
36. Williams S, Poulton R. Twins and maternal smoking: ordeals for the fetal origins hypothesis? A cohort study. BMJ 1999;318:897-900.
37. Law CM, de Sweit M, Osmond C, Fayers PM, Barker DJ, Cruddas AM et al. Initiation of hypertension in utero and its amplification throughout life. BMJ 1993;306:24-7.
38. Whincup P, Cook D, Papacosta O, Walker M. Birth weight and blood pressure: cross sectional and longitudinal relations in childhood. BMJ 1995;311:773-6.
39. Hales CN, Desai M, Ozanne SE, Crowther NJ. Fishing in the stream of diabetes: from measuring insulin to the control of fetal organogenesis. Biochem Soc Trans 1996;24:341-50.
40. Ozanne SE, Wang CL, Coleman N, Smith GD. Altered nuscle insulin sensitivity in the male offspring of protein-malnourished rats. Am J Physiol 1996;271:E1128-34.
41. Christensen K, Vaupel JW, Holm NV, Yashin AI. Mortality among twins after age 6: fetal origins hypothesis versus twin method. BMJ 1995;310:432-6.
42. Tibblin G, Eriksson M, Cnattingius S, Ekblom E. High birth weight as a predictor of prostate cancer risk. Epidemiology 1995;6:423-4.
43. Michels KB, Trichopoulos D, Robins JM, Rosner BA, Manson JE, Hunter DJ et al. Birthweight as a risk factor for breast cancer. Lancet 1996;348:1542-6.