Synergistic effect of PEG-400 and cyclodextrin to enhance solubility of progesterone

AAPS PharmSciTech

Volumn 4, Issue 1, 2003, Pages

  Nandi, Indranil ^a   Bateson, Michelle ^b   Bari, Mohammad ^c   Joshi, Hemant N ^d  

^a Geneva Pharmaceutical Technology Corp   (United States)

^b Galen Limited   (United Kingdom)

^c FOREST RESEARCH INSTITUTE   (United States)

^d Department of Pharmaceutical Research and Development ^*  (United States)

Author keywords

Cosolvent; Cyclodextrins; PEG 400; Progesterone; Solubilization; Synergism

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ACETIC ACID; ACETONITRILE; BETA CYCLODEXTRIN SULFOBUTYL ETHER; CYCLODEXTRIN; MACROGOL 400; POLYSORBATE 80; PROGESTERONE; SURFACTANT; MACROGOL DERIVATIVE; POLYSORBATE; SOLVENT;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL INTERACTION; CHROMATOGRAPHY; DILUTION; DRUG SOLUBILITY; ELECTRICITY; SOLUBILIZATION; SUSPENSION; CHEMISTRY; DRUG POTENTIATION; SOLUBILITY;

CYCLODEXTRINS; DRUG SYNERGISM; POLYETHYLENE GLYCOLS; POLYSORBATES; PROGESTERONE; SOLUBILITY; SOLVENTS;

EID: 0141576824     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt040101     Document Type: Article

References (13)

1. Loftsson T, Brewster ME. Pharmaceutical application of cyclodextrin: drug solubilization and stabilization. J Pharm Sci. 1996;85:1017-1025.
2. Wulff M, Alden M. Solid state studies of drug - cyclodextrin inclusion complexes in PEG 6000 prepared by a new method. Eur J Pharm. 1999;8:269-281.
3. Harada A. Preparation and structures of supramolecules between cyclodextrins and polymers. Coordin Chem Rev. 1996;148:115-133.
4. Loftsson T, Olafsdottir BJ, Fridriksdottir H, Jonsdottir S. Cyclodextrin complexations of NSAIDs: physicochemical characteristics. Eur J Pharm Sci. 1993;1:95-101.
5. Savolainen J, Jarvinen K, Taipale H, Jarho P, Loftsson T, Jarvinen T. Co-administration of a water-soluble polymer increases the usefulness of cyclodextrins in solid dosage forms. Pharm Res. 1998;15:1696-1701.
6. Loftsson T, Petersen DS. Cyclodextrin solubilization of ETH-615, a zwitterionic drug. Drug Dev Ind Pharm. 1998;24:365-370.
7. Loftsson T, Gudmundsdottir H, Sigurjonsdottir JF, et al. Cyclodextrin solubilization of benzodiazepines: formulation of midazolam nasal spray. Int J Pharm. 2001;212:29-40.
8. Zung JB. Influence of alcohol addition on the γ-CD:pyrene complex. J Phys Chem. 1991;95:6701-6709.
9. Pitha J, Hoshino T. Effect of ethanol on formation of inclusion complexes of hydroxypropylcyclodextrins with testosterone or with methyl orange. Int J Pharm. 1992;80:243-251.
10. Faucci MT, Mura P. Effect of water-soluble polymers on naproxen complexation with natural and chemically modified β-cyclodextrins. Drug Dev Ind Pharm. 2001;27:909-917.
11. Li P, Zhao L, Yalkowsky SH. Combined effect of cosolvent and cyclodextrin on solubilization of nonpolar drugs. J Pharm Sci. 1999;88:1107-1111.
12. Martin A. Physical Pharmacy: Physical Chemical Principles in the Pharmaceutical Sciences. Philadelphia, PA: Lea and Febiger; 1993:223.
13. Millard JW, Alvarex-Nunez FA, Yalkowsky SH. Solubilization by cosolvents - establishing useful constants for the log-linear model. Int J Pharm. 2002;245:153-166.