Pharmacological agents used for the treatment of stress urinary incontinence in women

Current Medical Research and Opinion

Volumn 19, Issue 6, 2003, Pages 485-490

  Viktrup, Lars ^a   Bump, Richard C ^a,b  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Duloxetine; Serotonin norepinephrine reuptake inhibitor; Stress urinary incontinence; Urethra

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLENBUTEROL; DULOXETINE; EPHEDRINE; ESTROGEN; FLAVOXATE; GESTAGEN; METHOXAMINE; MIDODRINE; NON PRESCRIPTION DRUG; NOREPHEDRINE; OXYBUTYNIN; PHENYLPROPANOLAMINE; PROPIVERINE; PSEUDOEPHEDRINE; SEROTONIN UPTAKE INHIBITOR; TOLTERODINE; TRICYCLIC ANTIDEPRESSANT AGENT; TROSPIUM CHLORIDE; VENLAFAXINE;

BREAST CANCER; CLINICAL TRIAL; CLOSED ANGLE GLAUCOMA; CONSTIPATION; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; EDEMA; ELECTROSTIMULATION; ENDOMETRIUM CANCER; ESTROGEN THERAPY; FEMALE; FLUID RETENTION; GALLBLADDER DISEASE; GASTROINTESTINAL SYMPTOM; HEADACHE; HEALTH CARE COST; HEART ARRHYTHMIA; HEART DISEASE; HEART FAILURE; HEART INFARCTION; HEART PALPITATION; HORMONE TRANSPORT; HUMAN; HYPERTENSION; NAUSEA; ORTHOSTATIC HYPOTENSION; PHYSICAL ACTIVITY; QUALITY OF LIFE; REVIEW; SIDE EFFECT; SLEEP DISORDER; SOMNOLENCE; STRESS INCONTINENCE; STROKE; TACHYCARDIA; TREMOR; URINE RETENTION; VERTIGO; VISUAL IMPAIRMENT; VOMITING; XEROSTOMIA;

EID: 0141570716     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079903125002126     Document Type: Review

References (36)

1. Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, van Kerrebroeck P, Victor A, Wein A. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 2002;21:167-78
2. Hunskaar S, Arnold EP, Burgio K, Diokno AC, Herzog AR, Mallett VT. Epidemiology and natural history of urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 2000;11:301-19
3. Fultz NH, Burgio K, Diokno AC, Kinchen KS, Obenchain R, Bump RC. Burden of stress urinary incontinence for community-dwelling women. Am J Obstet Gynecol 2003, in press
4. Viktrup L. Female stress and urge incontinence in family practice: insight into the lower urinary tract. Int J Clin Pract 2002;56:694-700
5. Andersson K-E, Appell R, Awad S, Chapple C, Drutz H, Finkbeiner A, Fourcroy J, Haab F, Wein A. Pharmacological treatment of urinary incontinence. In: Abrams P, Khoury S, Wein A, eds. Incontinence. Plymouth, UK: Health Publication, 2002:481-511
6. Ishiko O, Ushiroyama T, Saji F, Mitsuhashi Y, Tamura T, Yamamoto K, Kawamura Y, Ogita S. Beta(2)-adrenergic agonists and pelvic floor exercises for female stress incontinence. Int J Gynaecol Obstet 2000;71:39-44
7. Weil EH, Eerdmans PH, Dijkman GA, et al. Randomized double-blind placebo-controlled multicenter evaluation of efficacy and dose finding of midodrine hydrochloride in women with mild to moderate stress urinary incontinence: a phase II study. Int J Urogynecol 1998;9:145-50
8. Versi E, Cardozo L. Estrogens and the lower urinary tract function. In: Studd JWW, Whitehead MI, eds. The Menopause. London: Blackwell Scientific Publications, 1988:76-84
9. Hodgson BJ, Dumas S, Bolling DR, Heesch CM. Effect of estrogen on sensitivity of rabbit bladder and urethra to phenylephrine. Invest Urol 1978;16:67-9
10. Larsson B, Andersson KE, Batra S, Mattiasson A, Sjogren C. Effects of estradiol on norepinephrine-induced contraction, alpha adrenoceptor number and norepinephrine content in the female rabbit urethra. J Pharmacol Exp Ther 1984;229:557-63
11. Hextall A. Oestrogens and lower urinary tract function. Maturitas 2000;36:83-92
12. Grady D, Brown JS, Vittinghoff E, Applegate W, Varner E, Snyder T. Postmenopausal hormones and incontinence: the heart and estrogen/progestin replacement study. Obstet Gynecol 2001;97:116-20
13. Blakeman PJ, Hilton P, Bulmer JN. Cellular proliferation in the female lower urinary tract with reference to oestrogen status. Br J Obstet Gynaecol 2001;108:813-16
14. Anderson K-E. Current concepts in the treatment of disorders of micturition. Drugs 1988;35:477-94
15. Wein AJ. Pharmacology of incontinence. Urol Clin N Am 1995;22:557-77
16. Radley SC, Chapple CR, Bryan NP, Clarke DE, Craig DA. Effect of methoxamine on maximum urethral pressure in women with genuine stress incontinence: a placebo-controlled, double-blind crossover study. Neurourol Urodyn 2001;20:43-52
17. Beisland Ho, Fossberg E, Moer A, et al. Urethral insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. Urol Int 1984;39:211-16
18. Hilton P, Tweddel AL, Mayne C. Oral and intravaginal estrogens alone and in combination with alpha adrenergic stimulation in genuine stress incontinence. Int Urogyn J 1990;12:80-6
19. Gatti JM, Perez-Brayfield M, Kirsch AJ, Smith EA, Massad HC, Broecker BH. Acute urinary retention in children. J Urol 2001;165:918-21
20. Kernan WN, Viscoli CM, Brass LM, Broderick JP, Brott T, Feldmann E, Morgenstern LB, Wilterdink JL, Horwitz RI. Phenylpropanolamine and the risk of hemorrhagic stroke. N Engl J Med 2000;343:1826-32
21. Fleming GA. The FDA, regulation, and the risk of stroke (editorial). N Engl J Med 2000;343:1886-7
22. Brune ME, O'Neill AB, Gauvin DM, Katwala SP, Altenbach RJ, Brioni JD, Hancock AA, Sullivan JP. Comparison of alpha 1-adrenoceptor agonists in canine urethral pressure profilometry and abdominal leak point pressure models. J Urol 2001;166:1555-9
23. O'Neill AB, Buckner SA, Brune ME, Milicic I, Daza AV, Gauvin DM, Altenbach RJ, Meyer MD, Williams M, Sullivan JP, Brioni JD. Pharmacological properties of A-204176, a novel and selective alpha1A adrenergic agonist, in in vitro and in vivo models of urethral function. Life Sci 2001;70:181-97
24. Gleason DM, Reilly RJ, Bottacini MR, Pierce MJ. The urethral continence zone and its relation to stress incontinence. J Urol 1974;112:81-8
25. Rovner ES, Wein, AJ. Drug treatment of voiding dysfunction. In: Cardozo L, Staskin D, eds. Textbook of Female Urology and Urogynaecology. London: Isis Medical Media, 2001:357-407
26. Frazer A. Pharmacology of antidepressants. J Clin Psychopharm 1997;17:2-18S
27. Yasuda K, Kawabe K, Takimoto Y, Kondo A, Takaki R, Imabayashi K. A double-blind clinical trial of an alpha2-adrenergic agonist in stress incontinence. Int Urogynecol J 1993;4:146-51
28. Noguchi M, Eguchi Y, Ichiki J, Yahara J, Noda S. Therapeutic efficacy of clenbuterol for urinary incontinence after radical prostatectomy. Int J Urol 1997;4:480-3
29. Sussman D, Garely A. Treatment of overactive bladder with once-daily extended-release tolterodine or oxybutynin: The antimuscarinic clinical effectiveness trial (ACET). Curr Med Res Opin. 2002;18:177-84
30. Khullar V, Digesu A, Chaliha C, Khan M, Hutchins A. Mixed incontinence: how should it be treated? Neurourol Urodyn 2002;21:378-79
31. Chapple CR, Parkhouse H, Gardener C, Milroy EJ. Double-blind, placebo-controlled, cross-over study of flavoxate in the treatment of idiopathic detrusor instability. Br J Urol 1990;66:491-4
32. Meyhoff HH, Gerstenberg TC, Nordling J. Placebo - the drug of choice in female motor urge incontinence? Br J Urol 1983;55:34-7
33. Thor KB, Katofiasc MA. Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat. J Pharmacol Exp Ther 1995;274:1014-24
34. Norton P, Zinner NR, Yalcin I, Bump RC. Duloxetine versus placebo in the treatment of stress urinary incontinence. Am J Obstet Gynecol 2002;187:40-8
35. Zinner N, Dmochowski R, Miklos J, Norton P, Yalcin I, Bump R. Duloxetine versus placebo in the treatment of stress urinary incontinence (SUI). Neurourol Urodyn 2002;21:383-4
36. Katofiasc MA, Nissen J, Audia JE, Thor KB. Comparison of the effects of serotonin selective, norepinephrine selective, and dual serotonin and norepinephrine reuptake inhibitors on lower urinary tract function in cats. Life Sci 2002;71:1227-36