Adenovirus-mediated expression of dominant negative fibroblast growth factor (FGF) receptor 1 in thyroid cells blocks FGF effects and reduces goitrogenesis in mice

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 9, 2003, Pages 4472-4480

  Davies, Emma L ^a   Ramsden, James D ^a   Cocks, Helen ^a   Searle, Peter F ^a   Watkinson, John C ^b   Ueno, Hikaru ^c   Logan, Ann ^a   Franklyn, Jayne A ^a   Mautner, Vivien ^a   Eggo, Margaret C ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 1; GREEN FLUORESCENT PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE CONTROL; GENE REPLICATION; GENETIC CODE; GENETIC TRANSDUCTION; GOITER; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; THYROID CELL; THYROID FOLLICLE CELL;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; BLOOD VESSELS; BLOTTING, WESTERN; CELLS, CULTURED; CYCLIC AMP; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; GENES, DOMINANT; GENETIC VECTORS; GOITER; MALE; MICE; MICE, INBRED BALB C; RADIOIMMUNOASSAY; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; THYROID FUNCTION TESTS; THYROID GLAND; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

ADENOVIRIDAE; ANIMALIA;

EID: 0141564523     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030333     Document Type: Article

References (43)

1. Eggo MC, Hopkins JM, Franklyn JA, Johnson GD, Sanders DS, Sheppard MC 1995 Expression of fibroblast growth factors in thyroid cancer. J Clin Endocrinol Metab 80:1006-1011
2. Thompson SD, Franklyn JA, Watkinson JC, Verhaeg JM, Sheppard MC, Eggo MC 1998 Fibroblast growth factors 1 and 2 and fibroblast growth factor receptor 1 are elevated in thyroid hyperplasia. J Clin Endocrinol Metab 83:1336-1341
3. Becks GP, Logan A, Phillips ID, Wang J, Smith C, Sesousa D, Hill DJ 1994 Increase in FGF and FGFR mRNA during rat hyperplasia: temporal changes and cellular distribution. J Endocrinol 142:325-338
4. Patel VA, Hill DJ, Eggo MC, Sheppard MC, Becks GP, Logan A 1996 Changes in the immunohistochemical localisation of fibrobtast growth factor-2, transforming growth factor-β1 and thrombospondin-1 are associated with early angiogenic events in the hyperplastic rat thyroid. J Endocrinol 148:485-499
5. Cocks HC, Thompson S, Turner FE, Logan A, Franklyn JA, Watkinson JC, Eggo MC 2003 Role and regulation of the fibroblast growth factor axis in human thyroid follicular cells. Am J Physiol 284:168-176
6. 125I)iodine uptake in FRTL-5 rat thyroid cells. Proc Soc Exp Biol Med 194:240-244
7. 3 cells. J Endocrinol 127:39-46
8. De Vito WJ, Chanoine JP, Alex S, Fang SL, Stone S, Huber CA, Shalhoub V, Lian B, Stein GS, Braverman LE 1992 Effect of in vivo administration of recombinant acidic fibrobtast growth factor on thyroid function in the rat: induction of colloid goiter. Endocrinology 131:729-735
9. Powers CJ, McLeskey SW, Wellstein A 2000 FGFs and FGF signaling. Endocrine-Related Cancer 7:165-197
10. Ueno H, Gunn M, Dell K, Tseng A, Williams L 1992 A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor. J Biol Chem 267:1470-1479
11. Amaya E, Musci TJ, Kirschner MW 1991 Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. Cell 66:257-270
12. Armentano D, Zabner J, Sacks C, Sookdeo CC, Smith MP, St. George JA, Wadsworth SC, Smith AE, Gregory RJ 1997 Effect of the E4 region on the persistence of transgene expression from adenovirus vectors. J Virol 71:2408-2416
13. Lusky M, Christ M, Rittner K, Dieterle A, Dreyer D, Mourot B, Schultz H, Stoeckel F, Pavirani A, Mehtal M 1998 In vitro and in vivo biology of recombinant adenovirus vectors with E1, E1/E2A, or E1/E4 deleted. J Virol 72:2022-2032
14. Crystal RG, Harvey B, Wisnivesky JP, O'Donoghue KA, Chu KW, Maroni J, Muscat JC, Pippo AL, Wright CE, Kaner RJ, Leopold PL, Kessler PD, Rasmussen HS, Rosengart TK, Hollmann C 2002 Analysis of risk factors for local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions. Hum Gene Ther 13:65-100
15. Zeiger MA, Takiyama, Bishop JO, Ellison AR, Saji M, Levine MA 1996 Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma. Surgery 120:921-925
16. O'Malley BW, Adams RM, Sikes ML, Sawada T, Ledley FD 1993 Retrovirus-mediated gene transfer into canine thyroid using an ex vivo strategy. Hum Gene Ther 4:171-178
17. Eggo MC, Vitale M, Petric M, Burrow GN 1999 Effects of thyroid-stimulating hormone on the replicative cycle of vesicular stomatitis virus in primary cultured sheep thyroid cells. Biochimie 81:291-296
18. Zhang R, Straus FH, DeGroot LJ 2002 Cell-specific viral gene therapy of a Hurthle cell tumor. J Clin Endocrinol Metab 87:1407-1414
19. Isozaki O, Emoto N, Tsushima T, Sato Y, Shizume K, Demura H, Akamizu T, Kohn LD 1992 Opposite regulation of deoxyribonucleic acid synthesis and iodide uptake in rat thyroid cells by basic fibroblast growth factor: correlation with opposite regulation of c-fos and thyrotropin receptor gene expression. Endocrinology 131:2723-2732
20. Ambesi-Impiombato FS, Parks LAM, Coon HG 1980 Culture of hormone-dependent functional epithelial cells from rat thyroids. Proc Natl Acad Sci USA 77:3455-3459
21. Eggo MC, King WJ, Black EG, Sheppard MC 1996 Functional human thyroid cells and their insulin-like growth factor-binding proteins: regulation by thyrotropin, cyclic 3′,5′-adenosine monophosphate and growth factors. J. Clin Endocrinol Metab 81:3056-3062
22. Saffell JL, Williams EJ, Mason IJ, Walsh FS, Doherty P 1997 Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Neuron 18:231-242
23. Kozak M 1986 Regulation of protein synthesis in virus-infected animal cells. Adv Virus Res 31:229-292
24. Green NK, Youngs DJ, Neoptolemos JP, Friedlos F, Knox RJ, Springer CJ, Anlezark GM, Michael NP, Melton RG, Ford MJ, Young LS, Kerr DJ, Searle PF 1997 Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene. Cancer Gene Ther 4:229-238
25. Gilligan MG, Knox P, Weedon S, Barton R, Kerr DJ, Searle P, Young LS 1998 Adenoviral delivery of B7-1 (CD80) increases the immunogenicity of human ovarian and cervical carcinoma cells. Gene Ther 5:965-974
26. Latham JP, Searle PF, Mautner V, James ND 2000 Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: construction and testing of a tissue-specific adenovirus vector. Cancer Res 60:334-341
27. Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S, Axel R 1979 Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell 16:777-785
28. Graham FL, Prevec L 1995 Methods for construction of adenovirus vectors. Mol Biotechnol 3:207-220
29. Mautner V 1998 Methods for growth and purification of enteric adenovirus type 40. In: Wold W, ed. Adenovirus methods and protocols. Totowa, NJ: Humana Press; 283-294
30. Ueno H, Li JJ, Masuda S, Qi Z, Yamamoto H, Takeshita A 1997 Adenovirus-mediated expression of the secreted form of basic FGF (FGF-2) induces cellular proliferation and angiogenesis in vivo. Arterioscler Thromb Vasc Bio117:2453-2460
31. Wilkinson GW, Akrigg A 1992 Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector. Nucleic Acids Res 20:2233-2239
32. Debbage PL, Griebel J, Ried M, Gneiting T, DeVries A, Hutzler P 1998 Lectin intravital perfusion studies in tumor-bearing mice:micrometer-resolution, wide-area mapping of microvascular labeling, distinguishing efficiently and inefficiently perfused microregions in the tumor. J Histochem Cytochem 46:627-639
33. Howard C, Reed M 1998 Unbiased stereology: three-dimensional measurement in microscopy. Oxford: BIOS
34. Singh J, Hunt P, Eggo MC, Sheppard MC, Kirk CJ, Michell RH 1996 Thyroid stimulating hormone rapidly stimulates inositol polyphosphate formation in FRTL-5 thyrocytes without activating phosphoinositidase C. Biochem J 316:175-178
35. Patel V, Logan A, Sheppard MC, Ramsden JD, Eggo MC 2003 Characterisation of a strain of human thyroid endothelial cells and its interactions with thyroid follicular cells. Am J Physiol 284:E168-E176
36. Sato K, Yamazaki K, Shizume K, Kanaji Y, Obara T, Osumi K, Demura H, Yamaguchi K, Shibuya M 1995 Stimulation by thyroid stimulating hormone and Graves' immunoglobulin G of VEGF mRNA expression in human thyroid follicles in vitro and Flt mRNA in rat thyroid in vivo. J Clin Invest 96:1295-1302
37. Ramsden JD, Cocks HC, Shams M, Nijjar S, Watkinson JC, Sheppard MC, Ahmed A, Eggo MC 2001 Tie-2 is expressed on thyroid follicular cells, is increased in goiter, and is regulated by thyrotropin through cyclic adenosine 3′,5′-monophosphate. J Clin Endocrinol Metab 86:2709-2716
38. Feige J-J, Baird A 1989 Basic FGF is a substrate for protein phosphorylation and is phosphorylated by capillary endothelial cells in culture. Proc Natl Acad Sci USA 86:3174-3178
39. Kurtz A, Wang HL, Darwiche N, Harris V, Wellstein A 1997 Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis. Oncogene 14:2671-2681
40. Ye C, Feng C, Wang S, Liu Y, Li M 2002 Antiangiogenic and antitumor effects of endostatin on follicular thyroid carcinoma. Endocrinology 143:3522-3528
41. Ramsden JD, Yarram S, Mathews E, Watkinson JC, Eggo MC 2002 Thyroid follicular cells secrete plasminogen activators and can form angiostatin from plasminogen. J Endocrinol 173:475-481
42. Suomalainen M, Nakano MY, Boucke K, Keller S, Greber UK 2001 Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targehng of virus. EMBO J 20:1310-1319
43. Alesci S, Ramsey WJ, Bornstein SR, Chrousos GP, Hornsby PJ, Benvenga S, Trimarchi F, Ehrhart-Bornstein M 2002 Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapy. Proc Natl Acad Sci USA 89:7484-7489