Association of SH2-B to phosphorylated tyrosine residues in the activation loop of TRKB

Research Communications in Molecular Pathology and Pharmacology

Volumn 111, Issue 1-4, 2002, Pages 27-39

  Suzuki, Kenji ^a,b,d   Mizutani, Masaharu ^a,d   Hitomi, Yoshiaki ^b   Kizaki, Takako ^b   Ohno, Hideki ^b   Ishida, Hitoshi ^b   Haga, Shukoh ^c   Koizumi, Shinichi ^a  

^a NOVARTIS PHARMA K K   (Japan)

^b KYORIN UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Activation loop; Adaptor protein; Autophosphorylation; Binding; Frameshifts; Insertion sequences; Neurotrophins; PH; SH2 B ; SH2 domain; Trk receptors; Tyrosine kinase

Indexed keywords

ADAPTOR PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR BINDING PROTEIN; NEUROTROPHIN; TYROSINE; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CYTOPLASM; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; ENZYME ACTIVITY; FRAMESHIFT MUTATION; GENE INSERTION; IN VITRO STUDY; INHIBITION KINETICS; MOLECULAR CLONING; NERVE CELL; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REGULATORY MECHANISM; RESIDUE ANALYSIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; DNA PRIMERS; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RECEPTOR, TRKB; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; SRC HOMOLOGY DOMAINS; TWO-HYBRID SYSTEM TECHNIQUES; TYROSINE;

EID: 0141560408     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Bartel, P., Chien, C.T., Sternglanz, R., and Fields, S. (1993). Elimination of false positives that arise in using the two-hybrid system. Biotechniques 14: 920-924.
2. Berkemeier, L.R., Winslow, J.W., Kaplan, D.R., Nikolics, K., Goeddel, D.V., and Rosenthal, A. (1991). Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 7: 857-866.
3. Cunningham, M.E., Stephens, R.M., Kaplan, D.R., and Greene, L.A. (1997). Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor. J. Biol. Chem. 272: 10957-10967.
4. Cunningham, M.E., and Greene, L.A. (1998). A function-structure model for NGF-activated TRK. EMBO J. 17: 7282-7293.
5. Dickens, M., and Tavare, J.M. (1992). Analysis of the order of autophosphorylation of human insulin receptor tyrosines 1158, 1162 and 1163. Biochem. Biophys. Res. Commun. 186: 244-250.
6. Eustice, D.C., Feldman, P.A., Colberg-Poley, A.M., Buckery, R.M., and Neubauer, R.H. (1991). A sensitive method for the detection of □-galactosidase in transfected mammalian cells. Biotechniques 11: 739-743.
7. Fields, S., and Song, O. (1989). A novel genetic system to detect protein-protein interactions. Nature 340: 245-246.
8. Huang, X., Li, Y., Tanaka, K., Moore, K.G., and Hayashi, J.I. (1995). Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C γ1, Grb2, and phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA. 92: 11618-11622.
9. Hubbard, S.R., Wei, L., Ellis, L., and Hendrickson, W.A. (1994). Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372: 746-754.
10. Iseki, M., Takaki, S., and Takatsu, K. (2000). Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem. Biophys. Res. Commun. 272: 45-54.
11. Iwasaki, Y., Nishiyama, H., Suzuki, K., and Koizumi, S. (1997). Sequential cis/trans autophosphorylation in TrkB tyrosine kinase. Biochemistry 36: 2694-2700.
12. Kaplan, D.R., Hempstead, B.L., Martin-Zanca, D., Chao, M.V., and Parada, L.F. (1991). The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 252: 554-558.
13. Klein, R., Jing, S.Q., Nanduri, V., O'Rourke, E., and Barbacid, M. (1991). The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65: 189-197.
14. Klein, R., Nanduri, V., Jing, S.A., Lamballe, F., Tapley, P., Bryant, S., Cordon-Cardo, C., Jones, K.R., Reichardt, L.F., and Barbacid, M. (1991). The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 66: 395-403.
15. Kotani, K., Wilden, P., and Pillay, T.S. (1998). SH2-Bα is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase. Biochem. J. 335:103-109.
16. Lamballe, F., Klein, R., and Barbacid, M. (1991). trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66: 967-979.
17. Levi-Montalcini, R. (1987). The nerve growth factor 35 years later. EMBO J. 6: 1145-1154.
18. Li, Y., He, X., Schembri-King, J., Jakes, S., and Hayashi, J. (2000). Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation. J. Immunol. 164: 5199-5206.
19. Meakin, S.O., MacDonald, J.I., Gryz, E.A., Kubu, C.J., and Verdi, J.M. (1999). The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J. Biol. Chem. 274: 9861-9870.
20. Moodie, S.A., Alleman-Sposeto, J., and Gustafson, T.A. (1999). Identification of the APS protein as a novel insulin receptor substrate. J. Biol. Chem. 274: 11186-11893.
21. Nakamura, T., Sanokawa, R., Sasaki, Y., Ayusawa, D., Oishi, M., and Mori, N. (1996). N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. Oncogene 13: 1111-1121.
22. Nelms, K., O'Neill, T.J., Li, S., Hubbard, S.R., Gustafson, T.A., and Paul, W.E. (1999). Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain. Mamm. Genome 10: 1160-1167.
23. Osborne, M.A., Dalton, S., and Kochan, J.P. (1995). The yeast tribrid system-genetic detection of trans-phosphorylated ITAM-SH2-interactions. Biotechnology(NY) 13: 1474-1478.
24. Peng, X., Greene, L.A., Kaplan, D.R., and Stephens, R.M. (1995). Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis. Neuron 15: 395-406.
25. Qian, X., Riccio, A., Zhang, Y., and Ginty, D.D. (1998). Identification and characterization of novel substrates of Trk receptors in developing neurons. Neuron 21: 1017-1029.
26. Rabin, S.J., Cleghon, V., and Kaplan, D.R. (1993). SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol. Cell. Biol. 13: 2203-2213.
27. Rui, L., and Carter-Su, C. (1999). Identification of SH2-Bβ as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2. Proc. Natl. Acad. Sci. USA. 96: 7172-7177.
28. Rui, L., Herrington, J., and Carter-Su, C. (1999). SH2-B is required for nerve growth factor-induced neuronal differentiation. J. Biol. Chem. 274: 10590-10594.
29. Schlessinger, J. (2000). Cell signaling by receptor tyrosine kinases. Cell 103: 211-225.
30. Soppet, D., Escandon, E., Maragos, J., Middlemas, D.S., Reid, S.W., Blair, J., Burton, L.E., Stanton, B.R., Kaplan, D.R., Hunter, T., Nikolics, K., and Parada, L.F. (1991). The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell 65: 895-903.
31. Squinto, S.P., Stitt, T.N., Aldrich, T.H., Davis, S., Bianco, S.M., Radziejewski, C., Glass, D.J., Masiakowski, P., Furth, M.E., Valenzuela, D.M., DiStefano, P.S., and Yancopoulos, G.D. (1991). trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell 65: 885-893.
32. Stephens, R.M., Loeb, D.M., Copeland, T.D., Pawson, T., Greene, L.A., and Kaplan, D.R. (1994). Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ 1 to mediate NGF responses. Neuron 12: 691-705.
33. Takaki, S., Watts, J.D., Forbush, K.A., Nguyen, N.T., Hayashi, J., Alberola-Ila, J., Aebersold, R., and Perlmutter, R.M. (1997). Characterization of Lnk. An adaptor protein expressed in lymphocytes. J. Biol. Chem. 272: 14562-14570.
34. Ullrich, A., and Schlessinger, J. (1990). Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203-212.
35. van der Geer, P., Hunter, T., and Lindberg, R.A. (1994). Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell. Biol. 10: 251-337.
36. Wang, J., and Riedel, H. (1998). Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter. J. Biol. Chem. 27: 3136-3139.
37. Yasukawa, H., Misawa, H., Sakamoto, H., Masuhara, M., Sasaki, A., Wakioka, T., Ohtsuka, S., Imaizumi, T., Matsuda, T., Ihle, J.N., and Yoshimura, A. (1999). The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18: 1309-1320.
38. Yokouchi, M., Suzuki, R., Masuhara, M., Komiya, S., Inoue, A., and Yoshimura, A. (1997). Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. Oncogene 15: 7-15.
39. Yokouchi, M., Wakioka, T., Sakamoto, H., Yasukawa, H., Ohtsuka, S., Sasaki, A., Ohtsubo, M., Valius, M., Inoue, A., Komiya, S., and Yoshimura, A. (1999). APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. Oncogene 18: 759-767.
40. Yousaf, N., Deng, Y., Kang, Y., and Riedel, H.(2001). Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis. J. Biol. Chem. 276: 40940-40948.