Analysis of immunological nonresponsiveness to the 19-kilodalton fragment of merozoite surface protein 1 of Plasmodium yoelii: Rescue by chemical conjugation to diphtheria toxoid (DT) and enhancement of immunogenicity by prior DT vaccination

Infection and Immunity

Volumn 71, Issue 10, 2003, Pages 5700-5713

  Stanisic, Danielle I ^a,b   Martin, Laura B ^a,b,e   Liu, Xue Q ^a   Jackson, David ^b,c   Cooper, Juan ^a   Good, Michael F ^a,b,d  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b CRC for Vaccine Technology   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXOID; MALARIA VACCINE; MEMBRANE PROTEIN; MEROZOITE SURFACE PROTEIN 1; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONJUGATION; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; FEMALE; HAPLOTYPE; IMMUNE RESPONSE; IMMUNOGENICITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALARIA; MEROZOITE; MOUSE; MOUSE STRAIN; NONHUMAN; PLASMODIUM YOELII; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; T LYMPHOCYTE; VACCINATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIBODY SPECIFICITY; DIPHTHERIA TOXOID; FEMALE; MALARIA; MALARIA VACCINES; MEROZOITE SURFACE PROTEIN 1; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PEPTIDE FRAGMENTS; PLASMODIUM YOELII; SPECIES SPECIFICITY; VACCINES, CONJUGATE;

EID: 0141557672     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.10.5700-5713.2003     Document Type: Article

References (33)

1. 19. Infect. Immun. 68:2102-2109.
2. Blackman, M. J., H. G. Heidrich, S. Donachie, J. S. McBride, and A. A. Holder. 1990. A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies. J. Exp. Med. 172:379-382.
3. 33 as a noncovalently associated complex with other fragments of the MSP1. Mol. Biochem. Parasitol. 50:307-315.
4. Blackman, M. J., H. Whittle, and A. A. Holder. 1991. Processing of the Plasmodium falciparum major merozoite surface protein-1: identification of a 33-kilodalton secondary processing product which is shed prior to erythrocyte invasion. Mol. Biochem. Parasitol. 49:35-44.
5. Burns, J. M., Jr., W. R. Majarian, J. F. Young, T. M. Daly, and C. A. Long. 1989. A protective monoclonal antibody recognizes an epitope in the carboxyl-terminal cysteine-rich domain in the precursor of the major merozoite surface antigen of the rodent malarial parasite, Plasmodium yoelii. J. Immunol. 143:2670-2676.
6. Chang, S. P., S. E. Case, W. L. Gosnell, A. Hashimoto, K. J. Kramer, L. Q. Tam, C. Q. Hashiro, C. M. Nikaido, H. L. Gibson, C. T. Lee-Ng, P. J. Barr, B. T. Yokota, and G. S. Hut. 1996. A recombinant baculovirus 42-kilodalton C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 protects Aotus monkeys against malaria. Infect. Immun. 64:253-261.
7. Daly, T. M., and C. A. Long. 1993. A recombinant 15-kilodalton carboxyl-terminal fragment of Plasmodium yoelii yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice. Infect. Immun. 61:2462-2467.
8. Di John, D., S. S. Wasserman, J. R. Torres, M. J. Cortesia, J. Murillo, G. A. Losonsky, D. A. Herrington, D. Sturcher, and M. M. Levine. 1989. Effect of priming with carrier on response to conjugate vaccine. Lancet 2:1415-1418.
9. Egan, A., M. Waterfall, M. Pinder, A. Holder, and E. Riley. 1997. Characterization of human T- and B-cell epitopes in the C terminus of Plasmodium falciparum merozoite surface protein 1: evidence for poor T-cell recognition of polypeptides with numerous disulfide bonds. Infect. Immun. 65:3024-3031.
10. Good, M., W. Maloy, M. Lunde, H. Margalit, J. Cornette, G. Smith, B. Moss, L. Miller, and J. Berzofsky. 1987. Construction of synthetic immunogen: use of new T-helper epitope on malaria circumsporozoite protein. Science 235:1059-1062.
11. Herzenberg, L. A., and T. Tokuhisa. 1980. Carrier-priming leads to hapten-specific suppression. Nature 285:664-667.
12. 19) induces protective immunity to blood stage malaria infection in mice. Parasite Immunol. 20:413-420.
13. 19) of Plasmodium yoelii expressed in Saccharomyces cerevisiae: correlation of protection with antigen-specific antibody titer, but not with effector CD4+ T cells. J. Immunol. 159:3400-3411.
14. Hirunpetcharat, C., P. Vukovic, X. Q. Liu, D. C. Kaslow, L. H. Miller, and M. F. Good. 1999. Absolute requirement for an active immune response involving B cells and Th cells in immunity to Plasmodium yoelii passively acquired with antibodies to the 19-kDa carboxyl-terminal fragment of merozoite surface protein-1. J. Immunol. 162:7309-7314.
15. 19 expressed in S. cerevisiae. J. Immunol. 153:2544-2553.
16. 19) and T helper epitopes of tetanus toxoid. Vaccine 18:531-539.
17. Kumar, A., R. Arora, P. Kaur, V. S. Chauhan, and P. Sharma. 1992. "Universal" T helper cell determinants enhance immunogenicity of a Plasmodium falciparum merozoite surface antigen peptide. J. Immunol. 148:1499-1505.
18. Kumar, S., A. Yadava, D. B. Keister, J. H. Tian, M. Ohl, K. A. Perdue-Greenfield, L. H. Miller, and D. C. Kaslow. 1995. Immunogenicity and in vivo efficacy of recombinant Plasmodium falciparum merozoite surface protein-1 in Aotus monkeys. Mol. Med. 1:325-332.
19. Ling, I. T., S. A. Ogun, and A. A. Holder. 1994. Immunization against malaria with a recombinant protein. Parasite Immunol. 16:63-67.
20. Majarian, W. R., T. M. Daly, W. P. Weidanz, and C. A. Long. 1984. Passive immunization against murine malaria with an IgG3 monoclonal antibody. J. Immunol. 132:3131-3137.
21. Miller, J. F., and G. F. Mitchell. 1967. The thymus and the precursors of antigen reactive cells. Nature 216:659-663.
22. Pan, W., E. Ravot, R. Tolle, R. Frank, R. Mosbach, I. Turbachova, and H. Bujard. 1999. Vaccine candidate MSP-1 from Plasmodium falciparum: a redesigned 4917 bp polynucleotide enables synthesis and isolation of full-length protein from Escherichia coli and mammalian cells. Nucleic Acids Res. 27:1094-1103.
23. Peeters, C. C., A. M. Tenbergen-Meekes, J. T. Poolman, M. Beurret, B. J. Zegers, and G. T. Rijkers. 1991. Effect of carrier priming on immunogenicity of saccharide-protein conjugate vaccines. Infect. Immun. 59:3504-3510.
24. Ramasamy, R., D. A. Wijesundere, K. Nagendran, and M. S. Ramasamy. 1995. Antibody and clinical responses in volunteers to immunization with malaria peptide-diphtheria toxoid conjugates. Clin. Exp. Immunol. 99:168-174.
25. Riley, E. M. 1996. The role of MHC- and non-MHC-associated genes in determining the human immune response to malaria antigens. Parasitology 112(Suppl.):S39-S51.
26. Schutze, M. P., E. Deriaud, G. Przewlocki, and C. LeClerc. 1989. Carrier-induced epitopic suppression is initiated through clonal dominance. J. Immunol. 142:2635-2640.
27. Schutze, M. P., C. Leclerc, M. Jolivet, F. Audibert, and L. Chedid. 1985. Carrier-induced epitopic suppression, a major issue for future synthetic vaccines. J. Immunol. 135:2319-2322.
28. Schutze, M. P., C. Leclerc, F. R. Vogel, and L. Chedid. 1987. Epitopic suppression in synthetic vaccine models: analysis of the effector mechanisms. Cell. Immunol. 104:79-90.
29. Shah, S., R. Raghupathy, O. Singh, G. P. Talwar, and A. Sodhi. 1999. Prior immunity to a carrier enhances antibody responses to hCG in recipients of an hCG-carrier conjugate vaccine. Vaccine 17:3116-3123.
30. 19) and their role in immunity to malaria. Parasite Immunol. 20:263-278.
31. Tian, J. H., L. H. Miller, D. C. Kaslow, J. Ahlers, M. F. Good, D. W. Alling, J. A. Berzofsky, and S. Kumar. 1996. Genetic regulation of protective immune response in congenic strains of mice vaccinated with a subunit malaria vaccine. J. Immunol. 157:1176-1183.
32. Wipasa, J., H. Xu, M. Makobongo, M. Gatton, A. Stowers, and M. F. Good. 2002. Nature and specificity of the required protective immune response that develops postchallenge in mice vaccinated with the 19-kilodalton fragment of Plasmodium yoelii merozoite surface protein 1. Infect Immun. 70:6013-6020.
33. World Health Organization. 1999. Rolling back malaria, p. 49-63. In The world health report, 1999: making a difference. World Health Organization, Geneva, Switzerland.