Prior immunity to a carrier enhances antibody responses to hCG in recipients of an hCG-carrier conjugate vaccine

Vaccine

Volumn 17, Issue 23-24, 1999, Pages 3116-3123

  Shah, S ^a   Raghupathy, R ^a   Singh, Om ^a   Talwar, G P ^a   Sodhi, A ^b  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

Birth control vaccine; Carrier presensitization; Carrier induced suppression; Epitope specific suppression; HCG; Vaccine clinical trials

Indexed keywords

CHORIONIC GONADOTROPIN; VACCINE;

ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BIRTH CONTROL; BLOOD SAMPLING; DRUG EFFECT; EPITOPE MAPPING; HUMAN; HUMAN CELL; IMMUNITY; PRIORITY JOURNAL; RECIPIENT; T LYMPHOCYTE ACTIVATION; TARGET CELL; VACCINATION;

ADULT; ANTIBODIES, BACTERIAL; CARRIER PROTEINS; CHORIONIC GONADOTROPIN; CONTRACEPTION, IMMUNOLOGIC; DIPHTHERIA TOXOID; FEMALE; HUMANS; IMMUNIZATION SCHEDULE; LUTEINIZING HORMONE; TETANUS TOXOID; VACCINES, CONJUGATE;

EID: 0033529616     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00133-4     Document Type: Article

References (16)

1. Ishizaka K., Okudiara H. Reaginic antibody formation in the mouse II: enhancement and suppression of antibody formation by priming with carrier. J Immunol. 110:(4):1973;1067-1076.
2. Herzenberg L.A., Tokuhisa T., Herzenberg L.A. Carrier-priming leads to hapten-specific suppression. Nature. 285:1980;664-667.
3. Raghupathy R., Sad S., Arunan K. The immunogenetics of vaccinology: carrier-induced epitope-specific regulation. Immunology: perspectives in reproduction and infection. 1991;251 Oxford University Press.
4. Sad S., Gupta H.M., Talwar G.P., Raghupathy R. Carrier-induced suppression of the antibody response to a 'self' hapten. Immunology. 74:1991;223-227.
5. Kaliyaperumal A., Chauhan V.S., Talwar G.P., Raghupathy R. Carrier-induced epitope-specific regulation and its bypass in a protein-protein conjugate. Eur J Immunol. 25:1995;3375-3380.
6. Audibert F., Chedid L. Of antigens, adjuvants and carriers in synthetic vaccines. Chanon R.M., Lerner R.A. Modern approaches to vaccines, molecular and chemical basis of virus virulence and immunogenicity. 1984;397 Cold Spring Harbor Laboratory.
7. Schutze M.-P., Leclerc C., Jolivet M., Audibert F., Chedid L. Carrier-induced epitopic suppression, a major issue for future synthetic vaccines. J Immunol. 135:(4):1985;2319-2322.
8. Herzenberg L.A., Tokuhisa T., Hayakawa K. Epitope-specific regulation. Ann Rev Immunol. 1:1983;609-632.
9. Etlinger H.M., Felix A.M., Gillessen D., et al. Assessment in humans of a synthetic peptide-based vaccine against the sporozoite stage of the human malaria parasite, Plasmodium falciparum. J Immunol. 140:(2):1988;626-633.
10. Di John D., Wasserman S.S., Torres J.R., et al. Effect of priming with carrier on response to conjugate vaccine. Lancet. 8677:1989;1415-1418.
11. Schneerson R., Robbins J.B., Parke J.C. Jr., et al. Quantitative and qualitative analyses of serum antibodies elicited in adults by Haemophilus influenzae type b and pneumococcus type 6A capsular polysaccharide-tetanus toxoid conjugates. Infect Immun. 52:(2):1986;519-528.
12. Granoff S.D.M., Boies E.G., Munson R.S. Immunogenicity of Haemophilus influenzae type b polysaccharide-diphtheria toxoid conjugate vaccine in adults. J Pediatr. 105:1984;12-27.
13. Talwar G.P., Hingorani V., Kumar S., et al. Phase I clinical trial with three formulations of anti-human chorionic gonadotropin vaccine. Contraception. 41:(3):1990;301.
14. Talwar G.P., Singh Om, Pal R., et al. A vaccine that prevents pregnancy in women. Proc. Natl. Acad. Sci. USA. 91:1994;8532-8536.
15. Schutze M.-P., Deriaud E., Przewlocki G., LeClerc C. Carrier-induced epitopic suppression is initiated through clonal dominance. J Immunol. 142:1989;2635-2640.
16. Jacob C.O., Arnon R., Sela M. Effect of carrier on the immunogenic capacity of synthetic cholera vaccine. Mol Immunol. 22:(12):1985;1333-1339.