p53 and p21WAF1/CIP1 in hepatitis B virus related hepatocarcinogenesis

Hepato-Gastroenterology

Volumn 50, Issue 53, 2003, Pages 1292-1296

  Park, Young Nyun ^a   Chae, Kwang Jo ^a   Kwon, Kye Won ^a,c   Oh, Bong Kyeong ^a   Lee, Kwan Sik ^b   Lee, Woo Jung ^b   Park, Chanil ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

^c Soonchunhyang University College of Medicine   (South Korea)

Author keywords

Apoptosis; Dysplastic nodule; Hepatitis B virus; Hepatocarcinogenesis; Hepatocellular carcinoma; p21WAF1 CIP1; p53; Proliferation

Indexed keywords

DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; KI 67 ANTIGEN; PROTEIN P21; PROTEIN P53; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; MESSENGER RNA;

ARTICLE; CANCER GRADING; CHRONIC HEPATITIS; CONTROLLED STUDY; DYSPLASIA; GENE AMPLIFICATION; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTRICTION MAPPING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SECTION; TRANSCRIPTION REGULATION; UNDIFFERENTIATED CARCINOMA; VIRUS ETIOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HEPATITIS B; LIVER TUMOR; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; VIROLOGY;

CARCINOMA, HEPATOCELLULAR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATITIS B; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0141540520     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. International Working Party: Terminology of Nodular Hepatocellular Lesions. Hepatology 1995; 22:983-993.
2. Hytiroglou P, Theise ND, Schwartz M, Mor E, Miller C, Thung SN: Macroregenerative nodules in a series of adult cirrhotic liver explants: Issues of classification and nomenclature. Hepatology 1995; 21:703-708.
3. Theise ND: Macrogenerative (dysplastic) nodules and hepatocarcinogenesis: theoretical and clinical consideration. Semin Liver Dis 1995; 15:360-371.
4. Naka T, Toyota N, Kaneko T, Kaibara N: Protein expression of p53, p21 WAF1, and Rb as prognostic indicators in patients with surgically treated hepatocellular carcinomas. Anticancer Res 1998; 18:555-564.
5. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D: p21 is a universal inhibitor of cyclin kinases. Nature 1993; 366:701-704.
6. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ: The p21 Cdk-interacting proteins Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993; 75:805-816.
7. Waga S, Hannon GJ, Beach D, Stillman B: The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 1994; 369:574-578.
8. WAF1/CIP1 expression and p53 mutation in hepatocellular carcinomas. Hepatology 1997; 25:575-579.
9. WAF1/CIP1 protein expression is predominantly related to altered p53 in hepatocellular carcinomas. British J Cancer 2000; 83:50-55.
10. Qin LF, Ng IO, Fan ST, Ng M: p21/WAF1, p53 and PCNA expression and p53 mutation status in hepatocellular carcinoma. Int J Cancer 1998; 79:424-428.
11. WAF1/CIP1 massenger RNA expression in Hepatitis B, C virus-infected human hepatocellular carcinoma tissues. Cancer 2001; 91:2096-2103.
12. Furutani M, Arii S, Tanaka H, et al: Decreased expression and rare somatic mutation of the CIP1/WAF1 gene in human hepatocellular carcinoma. Cancer Lett 1997; 111:191-197.
13. Kang YK, Kim CJ, Kim WH, Kim HO, Kang GH, Kim YI: p53 mutation and overexpression in hepatocellular carcinoma and dysplastic nodules in the liver. Virchows Arch 1998; 432:27-32.
14. Maki CG, Howley PM: Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol Cell Biol 1997; 17:355-363.
15. El-Deiry WS, Harper JW, O'Connor PM, et al: WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 1994; 54:1169-1174.
16. Gorospe M, Holbrook NJ: Role of p21 in prostaglandin A2-mediated cellular arrest and death. Cancer Res 1996; 56:475-479.
17. WAF1/CIP1 expression by a temperature-sensitive mutant of human p53 does not lead apoptosis. Oncogene 1995; 11:2311-2316.
18. waf1/cip1 and prolongs G1→S transition via a p53-independent pathyway in human hepatoma cells. Oncogene 2000; 19:3384-3394.
19. WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res 1995; 55:2910-2919.
20. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D: Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res 1994; 54:3391-3395.
21. Zhang W, Grasso L, McClain CD, Gambel AM, Cha Y, Travali S, Deisseroth AB, Mercer WE: P53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res 1995; 55:668-674.
22. Elmore LW, Hancock AR, Chang S-F, et al: Hepatitis B virus X protein and p53 tumor suppressor interaction in the modulation of apoptosis. Proc Natl Acad Sci USA 1997; 94:14707-14712.
23. Greenblatt MS, Feitelson MA, Zhu M, et al: Integrity of p53 in hepatitis B x antigen-positive and -negative hepatocellular carcinoma. Cancer Res 1997; 57:426-432.
24. Wang XW, Gibson MK, Vermeulen W, et al: Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res 1995; 55:6012-6016.