P53 Mutation and overexpression in hepatocellular carcinoma and dysplastic nodules in the liver

Virchows Archiv

Volumn 432, Issue 1, 1998, Pages 27-32

  Kang, Yun Kyung ^a   Kim, Chong Jai ^b   Kim, Woo Ho ^b   Kim, Hyun Ok ^b   Kang, Gyeong Hoon ^b   Kim, Yong Il ^b  

^a Inje University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Dysplastic nodule; Hepatocellular carcinoma; Overexpression; P53 mutation

Indexed keywords

DNA; MUTANT PROTEIN; PROTEIN P53;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER NODULE; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

AGED; ANTIBODIES, MONOCLONAL; CARCINOMA, HEPATOCELLULAR; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; GENES, P53; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031931851     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004280050130     Document Type: Article

References (24)

1. Di Bisceglie AM, Rustgi VK, Hoofnagle JH, Dusheiko GM, Lotze MT (1988) Hepatocellular carcinoma. Ann Intern Med 108:390-491
2. Harris CC (1990) Hepatocellular carcinogenesis recent advances and speculations. Cancer Cells 2:146-148
3. Tsukuma H, Hiyama T, Tanaka S, Nakao M, Yabuuchi T, Kitamura T, Nakanishi K, Fujimoto I, Inoue A, Yamazaki H, Kawashima T (1993) Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 328:1798-1801
4. Sakamoto M, Hirohashi S, Shimosato Y (1991) Early stages of multistep hepato-carcinogenesis: Adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 22:172-178
5. Hoso M, Nakanuma Y (1991) Cytophotometric DNA analysis of adenomatous hyperplasia in cirrhotic livers. Virchows Arch [A] 418:401-404
6. Eguchi A, Nakashima O, Okugaira S, Sugihara S, Kojiro M (1992) Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma. Hepatology 15:843-847
7. Orsatti G, Theise ND, Thung SN, Paronetto F (1993) DNA image cytometric analysis of macroregenerative nodules (adenomatous hyperplasia) of the liver: evidence in support of their preneoplastic nature. Hepatology 17:621-627
8. Hytiroglou P, Theise ND, Schwartz M, Mor E, Miller C, Thung SN (1995) Macroregenerative nodules in a series of adult cirrhotic liver explants: issues of classification and nomenclature. Hepatology 21:703-708
9. International Working Party (1995) Terminology of nodular hepatocellular lesions. Hepatology 22:983-993
10. Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759-767
11. Casson AG, Mukhopadhyay T, Cleary KR, Ro JY, Levin B, Roth JA (1991) p53 gene mutation in Barrett's epithelium and esophageal cancer. Cancer Res 51: 4495-4499
12. Wang LD, Hong JY, Qui SL, Gao H, Yang CS (1993) Accumulation of p53 protein in human esophageal precancerous lesions. A possible early biomarker of carcinogenesis. Cancer Res 53:1783-1787
13. Tohdo H, Yokozaki H, Haruma K, Kajiyama G, Tahara E (1993) p53 Gene mutations in gastric adenomas. Virchows Arch [B] 63:191-195
14. Kaklamanis L, Gatter KC, Mortensen N, Baigrie RJ, Heryet A, Lane DP (1993) p53 expression in colorectal adenomas. Am J Pathol 142:87-93
15. Kitamura H, Kameda Y, Nakamura N, Nakatani Y, Inayama Y, Iida M, Noda K, Ogawa N, Shibagaki T, Kanisawa M (1995) Proliferative potential and p53 overexpression in precursor and early stage lesions of bronchioloalveolar lung carcinoma. Am J Pathol 146:876-887
16. Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878
17. Ng IOL, Srivastava G, Chung LP, Tsang SWY, Ng MMT (1994) Overexpression and point mutations of p53 tumor suppressor gene in hepatocellular carcinoma in Hong Kong Chinese people. Cancer 74:30-37
18. Aguilar F, Harris CC, Sun T, Hollstein M, Cerutti P (1994) Geographic variation of p53 mutational profile in nonmalignant human liver. Science 264:1317-1319
19. Livni N, Eid A, Ilan Y, Rivkind A, Rosenmann E, Blendis LM, Shouval D, Galun E (1995) p53 expression in patients with cirrhosis with and without hepatocellular carcinoma. Cancer 75:2420-2426
20. Zou HQ, Tang ZY, Ye SL (1994) Mutation of p53 gene and expression of alphafetoprotein during hepatocarcinogenesis. Natl Med J China 74:474-475
21. Grafstrom RC, Fornace AJ, Autrup H, Lechner JF, Harris CC (1983) Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells. Science 220:216-218
22. Aihara T, Noguchi S, Sasaki Y, Nakano H, Monden M, Imaoka S (1996) Clonal analysis of precancerous lesion of hepatocellular carcinoma. Gastroenterology 111:455-461
23. Baker SJ, Preisinger AC, Jessup MJ, Paraskeva C, Markowitz S, Willson JKV, Hamilton S, Vogelstein B (1990) p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 50:7719-7722
24. Dix B, Robbins P, Carrello S, House A, Iacopetta B (1994) Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas. Br J Cancer 70:585-590