Tissue-specific regulation of the human acute-phase serum amyloid A genes, SAA1 and SAA2, by glucocorticoids in hepatic and epithelial cells

European Journal of Immunology

Volumn 33, Issue 9, 2003, Pages 2630-2639

  Thorn, Caroline F ^a   Lu, Zhi Yong ^a   Whitehead, Alexander S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Acute phase response; Cytokine; Glucocorticoid; Serum amyloid A; Tissue specific regulation

Indexed keywords

ACUTE PHASE PROTEIN; CYTOKINE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; SERUM AMYLOID A;

ACUTE PHASE RESPONSE; ARTICLE; CELL STIMULATION; CELL STRAIN HEPG2; CONTROLLED STUDY; EPITHELIUM CELL; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC TRANSCRIPTION; HEPATOMA CELL; HUMAN; HUMAN CELL; INFECTION; INFLAMMATION; INJURY; LIVER; LIVER CELL; MEDIATOR; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TISSUE SPECIFICITY; TUMOR CELL LINE; UPREGULATION;

CYTOKINES; EPITHELIUM; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; LIVER; NF-KAPPA B; PROMOTER REGIONS (GENETICS); SERUM AMYLOID A PROTEIN; TRANSFECTION;

EID: 0141539251     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200323985     Document Type: Article

References (35)

1. Baumann, H. and Gauldie, J., The acute-phase response. Immunol. Today 1994. 15: 74-80.
2. Koj, A., Termination of acute-phase response: role of some cytokines and anti-inflammatory drugs. Gen. Pharmacol. 1998. 31: 9-18.
3. Adcock, I. M., Molecular mechanisms of glucocorticosteroid actions. Pulm. Pharmacol. Ther. 2000. 13: 115-126.
4. Uhlar, C. M. and Whitehead, A. S., Serum amyloid A, the major vertebrate acute-phase reactant. Eur. J. Biochem. 1999. 265: 501-523.
5. Meek, R. L., Urieli-Shoval, S. and Benditt, E. P., Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function. Proc. Natl. Acad. Sci. USA 1994. 91: 3186-3190.
6. Urieli-Shoval, S., Meek, R. L., Hanson, R. H., Eriksen, N. and Benditt, E. P., Human serum amyloid A genes are expressed in monocyte/macrophage cell lines. Am. J. Pathol. 1994. 145: 650-660.
7. O'Hara, R., Murphy, E. P., Whitehead, A. S., FitzGerald, O. and Bresnihan, B., Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue. Arthritis Res. 2000. 2: 142-144.
8. Urieli-Shoval, S., Cohen, P., Eisenberg, S. and Matzner, Y., Widespread expression of serum amyloid A in histologically normal human tissues. Predominant localization to the epithelium. J. Histochem. Cytochem. 1998. 46: 1377-1384.
9. Steel, D. M., Donoghue, F. C., O'Neill, R. M., Uhlar, C. M. and Whitehead, A. S., Expression and regulation of constitutive and acute-phase serum amyloid A mRNAs in hepatic and nonhepatic cell lines. Scand. J. Immunol. 1996. 44: 493-500.
10. Kumon, Y., Suehiro, T., Hashimoto, K. and Sipe, J. D., Dexamethasone, but not IL-1 alone, upregulates acute-phase serum amyloid A gene expression and production by cultured human aortic smooth muscle cells. Scand. J. Immunol. 2001. 53: 7-12.
11. Husby, G., Husebekk, A., Skogen, B., Sletten, K., Marhaug, G., Magnus, J. and Syversen, V., Serum amyloid A (SAA)-the precursor of protein AA in secondary amyloidosis. Adv. Exp. Med. Biol. 1988. 243: 185-192.
12. Kindy, M. S., Yu, J., Guo, J. T. and Zhu, H., Apolipoprotein Serum Amyloid A in Alzheimer's Disease. J. Alzheimers. Dis. 1999. 1: 155-167.
13. Coetzee, G. A., Strachan, A. F., van der Westhuyzen, D. R., Hoppe, H. C., Jeenah, M. S. and de Beer, F. C., Serum amyloid A-containing human high density lipoprotein 3. Density, size, and apolipoprotein composition. J. Biol. Chem. 1986. 261: 9644-9651.
14. Badolato, R., Wang, J. M., Murphy, W. J., Lloyd, A. R., Michiel, D. F., Bausserman, L. L., Kelvin, D. J. and Oppenheim, J. J., Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes. J. Exp. Med. 1994. 180: 203-209.
15. Badolato, R., Johnston, J. A., Wang, J. M., McVicar, D., Xu, L. L., Oppenheim, J. J. and Kelvin, D. J., Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway. J. Immunol. 1995. 155: 4004-4010.
16. He, R., Sang, H. and Ye, R. D., Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R. Blood 2002. 26: 26.
17. Badolato, R., Wang, J. M., Stornello, S. L., Ponzi, A. N., Duse, M. and Musso, T., Serum amyloid A is an activator of PMN antimicrobial functions: induction of degranulation, phagocytosis, and enhancement of anti-Candida activity. J. Leukoc. Biol. 2000. 67: 381-386.
18. Hirakura, Y., Carreras, I., Sipe, J. D. and Kagan, B. L., Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense. Amyloid 2002. 9: 13-23.
19. Wang, L., Lashuel, H. A., Walz, T. and Colon, W., Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel. Proc. Natl. Acad. Sci. USA 2002. 27: 27.
20. Steel, D. M., Sellar, G. C., Uhlar, C. M., Simon, S., DeBeer, F. C. and Whitehead, A. S., A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2). Genomics 1993. 16: 447-454.
21. Betts, J. C., Cheshire, J. K., Akira, S., Kishimoto, T. and Woo, P., The role of NF-kappa B and NF-IL-6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6. J. Biol. Chem. 1993. 268: 25624-25631.
22. Thorn, C. F. and Whitehead, A. S., Differential glucocorticoid enhancement of the cytokine-driven transcriptional activation of the human acute-phase serum amyloid A genes, SAA1 and SAA2. J. Immunol. 2002. 169: 399-406.
23. Steel, D. M. and Whitehead, A. S., Heterogeneous modulation of acute-phase-reactant mRNA levels by interleukin-1 beta and interleukin-6 in the human hepatoma cell line PLC/PRF/5 [published erratum appeared in Biochem J 1992. 281: 879]. Biochem. J. 1991. 277: 477-482.
24. Ganapathi, M. K., Rzewnicki, D., Samols, D., Jiang, S. L. and Kushner, I., Effect of combinations of cytokines and hormones on synthesis of serum amyloid A and C-reactive protein in Hep3B cells. J. Immunol. 1991. 147: 1261-1265.
25. Uhlar, C. M. and Whitehead, A. S., The kinetics and magnitude of the synergistic activation of the serum amyloid A promoter by IL-1 beta and IL-6 is determined by the order of cytokine addition. Scand. J. Immunol. 1999. 49: 399-404.
26. Baumann, H., Jahreis, G. P. and Morella, K. K., Interaction of cytokine- and glucocorticoid-response elements of acute-phase plasma protein genes. Importance of glucocorticoid receptor level and cell type for regulation of the elements from rat alpha 1-acid glycoprotein and beta-fibrinogen genes. J. Biol. Chem. 1990. 265: 22275-22281.
27. Doucas, V., Shi, Y., Miyamoto, S., West, A., Verma, I. and Evans, R. M., Cytoplasmic catalytic subunit of protein kinase A mediates cross- repression by NF-kappa B and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 2000. 97: 11893-11898.
28. Schulz, M., Eggert, M., Baniahmad, A., Dostert, A., Heinzel, T. and Renkawitz, R., RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding. J. Biol. Chem. 2002. 277: 26238-26243.
29. Kumon, Y., Suehiro, T., Faulkes, D. J., Hosakawa, T., Ikeda, Y., Woo, P., Sipe, J. D. and Hashimoto, K., Transcriptional regulation of serum amyloid A1 gene expression in human aortic smooth muscle cells involves CCAAT/enhancer binding proteins (C/EBP) and is distinct from HepG2 cells. Scand. J. Immunol. 2002. 56: 504-511.
30. Jensen, L. E., Hiney, M. P., Shields, D. C., Uhlar, C. M., Lindsay, A. J. and Whitehead, A. S., Acute-phase proteins in salmonids: evolutionary analyses and acute-phase response. J. Immunol. 1997. 158: 384-392.
31. Lu, S. Y., Rodriguez, M. and Liao, W. S., YY1 represses rat serum amyloid A1 gene transcription and is antagonized by NF-kappa B during acute-phase response. Mol. Cell. Biol. 1994. 14: 6253-6263.
32. Vu-Dac, N., Chopin-Delannoy, S., Gervois, P., Bonnelye, E., Martin, G., Fruchart, J. C., Laudet, V. and Staels, B., The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates. J. Biol. Chem. 1998. 273: 25713-25720.
33. Yamazaki, K., Kuromitsu, J. and Tanaka, I., Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator-activated receptor alpha agonists. Biochem. Biophys. Res. Commun. 2002. 290: 1114-1122.
34. Gervois, P., Vu-Dac, N., Kleemann, R., Kockx, M., Dubois, G., Laine, B., Kosykh, V., Fruchart, J. C., Kooistra, T. and Staels, B., Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta. J. Biol. Chem. 2001. 276: 33471-33477.
35. Jensen, L. E., Muzio, M., Mantovani, A. and Whitehead, A. S., IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein. J. Immunol. 2000. 164: 5277-5286.