Pharmacological effects of KRP-197 on the human isolated urinary bladder

Urologia Internationalis

Volumn 71, Issue 3, 2003, Pages 290-298

  Murakami, Shigetaka ^a   Yoshida, Masaki ^a   Iwashita, Hitoshi ^a   Otani, Masayuki ^a   Miyamae, Koichi ^a   Masunaga, Koichi ^a   Miyamoto, Yutaka ^a   Inadome, Akito ^a   Ueda, Shoichi ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Antimuscarinic drug; KRP 197; Postjunctional muscarinic receptor; Prejunctional muscarinic receptor; Urinary bladder

Indexed keywords

4 (2 METHYLIMIDAZOL 1 YL) 2,2 DIPHENYLBUTYRAMIDE; ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; ATROPINE; CALCIUM CHLORIDE; CARBACHOL; KRP 197; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; OXYBUTYNIN; POTASSIUM CHLORIDE; PROPIVERINE; PROSTAGLANDIN; PURINE RECEPTOR; TETRODOTOXIN; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

ACETYLCHOLINE RELEASE; ADULT; AGED; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DETRUSOR MUSCLE; ELECTROSTIMULATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; MICRODIALYSIS; MUSCLE EXCITATION; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION;

AGED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMIDAZOLES; MALE; MUSCARINIC ANTAGONISTS; URINARY BLADDER;

EID: 0141538162     PISSN: 00421138     EISSN: None     Source Type: Journal    
DOI: 10.1159/000072681     Document Type: Article

References (27)

1. Steers WD: Physiology and pharmacology of the bladder and urethra; in Walsh PC, Retik AB, Vaughan ED Jr, Wein AJ (eds): Campbell's Urology, ed 7. Philadelphia, Saunders, 1997, vol 1, pp 870-915.
2. 4 receptor subtype. Br J Pharmacol 2000;129:493-500.
3. Kondo S, Morita T: A study of muscarinic cholinergic receptor subtypes in human detrusor muscle using radioligand binding techniques. Jpn J Urol 1993;84:1255-1261.
4. Wang P, Luthin GR, Ruggieri MR: Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins. J Pharmacol Exp Ther 1995;273:959-966.
5. Mutoh S, Latifpour J, Saito M, Weiss RM: Evidence for the presence of regional differences in the subtype specificity of muscarinic receptors in rabbit lower urinary tract. J Urol 1997;157:717-721.
6. 3 muscarinic receptors in overactive bladder. Urology 2000;55(suppl 5A):47-49.
7. Eglen RM, Hegde SS, Watson N: Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 1996;48:531-565.
8. Daniels DV, Meloy TD, Loury DN, Hegde SS, Ford AP, Eglen RM: Functional pharmacological characterization of the muscarinic cholinoceptor-mediated inhibition of adenylyl cyclase in primary cultured human bladder detrusor muscle cell (abstract). Life Sci 1999;64:590.
9. Somogyi GT, de Groat WC: Function, signal transduction mechanisms and plasticity of presynaptic muscarinic receptors in the urinary bladder. Life Sci 1999;64:411-418.
10. Shen A, Mitchelson F: Characterisation of the prejunctional inhibitory muscarinic receptor on cholinergic nerves in the rat urinary bladder. Eur J Pharmacol 2001;413:179-187.
11. Miyachi H, Kiyota H, Uchiki H, Segawa M: Synthesis and antimuscarinic activity of a series of 4-(1-imidazolyl)-2,2-diphenylbutyramides. Bioorg Med Chem 1999;7:1151-1161.
12. Yono M, Yoshida M, Wada Y, Kikukawa H, Takahashi W, Inadome A, Seshita H, Ueda S: Pharmacological effects of tolterodine on human isolated urinary bladder. Eur J Pharmacol 1999;368:223-230.
13. Yoshida M, Homma Y, Inadome A, Yono M, Seshita H, Miyamoto Y, Murakami S, Kawabe K, Ueda S: Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscles. Exp Gerontol 2001;36:99-109.
14. Arunlakshana O, Schild HO: Some quantitative uses of drug antagonists. Br J Pharmacol 1959;14:48-58.
15. Inadome A, Yoshida M, Takahashi W, Yono M, Seshita H, Miyamoto Y, Kawano T, Ueda S: Prejunctional muscarinic receptor modulating acetylcholine release in rabbit detrusor muscles. Urol Int 1998;61:135-141.
16. Latifpour J, Gousse A, Kondo S, Morita T, Weiss RM: Effects of experimental diabetes on biochemical and functional characteristics of bladder muscarinic receptors. J Pharmacol Exp Ther 1989;248:81-88.
17. Miyachi H, Kiyota H, Uchiki H, Segawa M: Novel imidazole derivatives with subtype-selective antimuscarinic activity (1). Bioorg Med Chem Lett 1998;8:1807-1812.
18. Miyachi H, Kiyota H, Uchiki H, Segawa M: Novel imidazole derivatives with subtype-selective antimuscarinic activity (2). Bioorg Med Chem Lett 1998;8:2163-2168.
19. Aida Y, Kaneko Y, Kasama T: Effect of oxybutynin hydrochloride on isolated smooth muscles (ileum, urinary bladder and urethra). Folia Pharmacol Jpn 1986;87:629-639.
20. Haruno A, Yamasaki Y, Miyoshi K, Miyake H, Tsuchiya K, Kosaka M, Nagai M, Iriki M: Effects of propiverine hydrochloride and its metabolites on isolated guinea pig urinary bladder. Folia Pharmacol Jpn 1989;94:145-150.
21. Wada Y, Yoshida M, Kitani K, Kikukawa H, Ichinose A, Takahashi W, Gotoh S, Inadome A, Machida J, Ueda S: Comparison of the effects of various anticholinergic drugs on human isolated urinary bladder. Arch Int Pharmacodyn Ther 1995;330:76-89.
22. Kikukawa H, Yoshida M, Wada Y, Nishi K, Ueda S: Pharmacologic actions of temiverine (p-INN) and its active metabolite, RCC-36, on isolated human urinary bladder muscle. Int J Urol 1998;5:268-275.
23. Luheshi G, Zar A: Purinoceptor desensitization impairs but does not abolish the non-cholinergic motor transmission in rat isolated urinary bladder. Eur J Pharmacol 1990;185:203-208.
24. Zar MA, Iravani MM, Luheshi GN: Effect of nifedipine on the contractile responses of the isolated rat bladder. J Urol 1990;143:835-839.
25. Greaney MD, Marshall DL, Bailey BA, Acworth IN: Improved method for the routine analysis of acetylcholine release in vivo: Quantitation in the presence and absence of esterase inhibitor. J Chromatogr 1993;622:125-135.
26. Tobin G, Sj̈gren C: Prejunctional facilitatory and inhibitory modulation of parasympathetic nerve transmission in the rabbit bladder. J Auton Nerv Syst 1998;68:153-156.
27. Somogyi GT, Zernova GV, Yoshiyama M, Yamamoto T, de Groat WC: Frequency dependence of muscarinic facilitation of transmitter release in urinary bladder strips from neurally intact or chronic spinal cord transected rats. Br J Pharmacol 1998;125:241-246.