Subacute toxicities and toxicokinetics of a new erectogenic, DA-8159, after single and 4-week repeated oral administration in dogs

Biopharmaceutics and Drug Disposition

Volumn 22, Issue 3, 2001, Pages 109-117

  Shim, Hyun J ^a,b   Lee, Eun J ^a   Kim, Jung H ^b   Kim, Soon H ^b   Kwon, Jong W ^b   Kim, Won B ^b   Cha, Shin W ^c   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

^b Dong A Pharmaceutical Company   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

DA 8159; Dogs; Single and 4 week oral administration; Subacute toxicities; Toxicokinetics

Indexed keywords

5 [2 PROPYLOXY 5 (1 METHYL 2 PYROLLIDINYLETHYLAMIDO SULFONYL) PHENYL] 1 METHYL 3 PROPYL 1,6 DIHYDRO 7H PYRAZOLO(4,3 D) PYRIMIDIN 7 ONE; PHOSPHODIESTERASE INHIBITOR; SILDENAFIL; UDENAFIL; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG ACCUMULATION; DRUG BLOOD LEVEL; FEMALE; IMMUNE SYSTEM; LIVER; MALE; NONHUMAN; OVARY; PANCREAS; TOXICOKINETICS;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; DOGS; FEMALE; IMPOTENCE; KINETICS; MALE; MOTOR ACTIVITY; PHOSPHODIESTERASE INHIBITORS; PYRIMIDINES;

EID: 0035667185     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.263     Document Type: Article

References (4)

1. Safety and efficacy of sildenafil citrate in the treatment of male erectile dysfunction
2. Factors influencing the protein binding of a new phosphodiesterase V inhibitor, DA-8159, using an equilibrium dialysis technique
3. Critical evaluation of the potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve