Synthesis of 4′-C-ethynyl and 4′-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 887-889

  Kohgo, Satoru ^a   Yamada, Kohei ^a   Kitano, Kenji ^a   Sakata, Shinji ^a   Hayakawa, Hiroyuki ^a   Nameki, Daisuke ^b   Kodama, Eiichi ^b   Matsuoka, Masao ^b   Mitsuya, Hiroaki ^c   Ohrui, Hiroshi ^d  

^a YAMASA CORPORATION   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

4 C Substituted nucleosides; Anti HIV activitiy; Drug resistant HIV

Indexed keywords

2' DEOXYNUCLEOSIDE; 4' C CYANOPURINE NUCLEOSIDE; 4' C ETHYNYLPURINE NUCLEOSIDE; ANTIRETROVIRUS AGENT; DIDANOSINE; LAMIVUDINE; PURINE NUCLEOSIDE DERIVATIVE; STAVUDINE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DEOXYRIBONUCLEOSIDE; DRUG DERIVATIVE; GUANINE; PURINE NUCLEOSIDE;

ANTIVIRAL ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANTIBIOTIC RESISTANCE; ARTICLE; CHEMISTRY; CLASSIFICATION; DRUG EFFECT; HUMAN IMMUNODEFICIENCY VIRUS; MICROBIOLOGICAL EXAMINATION; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; DEOXYRIBONUCLEOSIDES; DRUG RESISTANCE, VIRAL; GUANINE; HIV; MICROBIAL SENSITIVITY TESTS; PURINE NUCLEOSIDES;

EID: 0141537085     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022678     Document Type: Conference Paper

References (3)

1. Ohrui, H.; Kohgo, S.; Kitano, K.; Sakata, S.; Kodama, E.; Yoshimura, K.; Matsuoka, M.; Shigeta, S.; Mitsuya, H. Synthesis of 4′-C-ethynyl-β -D-arabino-and 4′-C-ethynyl-2′-deoxy-β-D-ribo pentofuranosylpyrimidines and -purines and evaluation of their anti-HIV activity. J. Med. Chem. 2000, 43, 4516-4525.
2. Kodama, E.; Kohgo, S.; Kitano, K.; Machida, H.; Gatanaga, H.; Shigeta, S.; Matsuoka, M.; Ohrui, H.; Mitsuya, H. 4′-Ethynyl nucleosides analogs: Potent inhibitors of multidrug-resistant human immunodeficiency virus variants in vitro. Antivir. Chem. Chemother. 2001, 45, 1539-1546.
3. Uchida, H.; Maeda, Y.; Mitsuya, H. HIV-1 protease does not play a critical role in the early steps of HIV-1 infection. Antiviral Res. 1997, 36, 107-113.