Challenging the concept of a dynamic penumbra in acute ischemic stroke

Stroke

Volumn 34, Issue 10, 2003, Pages 2434-2435

  Koennecke, Hans Christian ^a  

^a Ev Krankhs K Elisabeth Herzberge ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOLYTIC AGENT; XENON;

BLOOD FLOW VELOCITY; BODY TEMPERATURE; BRAIN BLOOD FLOW; BRAIN METABOLISM; BRAIN PERFUSION; CEREBROVASCULAR ACCIDENT; COLLATERAL CIRCULATION; COMPUTER ASSISTED TOMOGRAPHY; HUMAN; IMAGE ANALYSIS; NOTE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT SELECTION; PRIORITY JOURNAL; RECANALIZATION; RETROSPECTIVE STUDY; TREATMENT INDICATION; TREATMENT OUTCOME; ACUTE DISEASE; BRAIN; BRAIN CIRCULATION; BRAIN ISCHEMIA; DISEASE COURSE; METHODOLOGY; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING; VASCULARIZATION;

ACUTE DISEASE; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; DISEASE PROGRESSION; HUMANS; PREDICTIVE VALUE OF TESTS; RESEARCH DESIGN;

EID: 0141530972     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000095162.75634.CE     Document Type: Note

References (25)

1. Astrup J, Siesjö BK, Symon L. Threshold in cerebral ischemia: the ischemic penumbra. Stroke. 1981;12:723-725.
2. Fisher M. Characterizing the target of acute stroke therapy. Stroke. 1997;28:866-872.
3. Heiss WD. Ischemic penumbra: evidence from functional imaging in man. J Cereb Blood Flow Metab. 2000;20:1276-1293.
4. Rordorf G, Koroshetz WJ, Copen WA, Cramer SC, Schaefer PW, Budzik RF Jr, Schwamm LH, Buonanno F, Sorensen AG, Gonzalez G. Regional ischemia and ischemic injury in patients with acute middle cerebral artery stroke as defined by early diffusion-weighted and perfusion-weighted MRI. Stroke. 1998;29:939-943.
5. Barber PA, Davis SM, Darby DG, Desmond PM, Gerraty RP, Yang Q, Jolley D, Donnan GA, Tress BM. Absent middle cerebral artery flow predicts the presence and evolution of the ischemic penumbra. Neurology. 1999;52:1125-1132.
6. Back T. Pathophysiology of the ischemic penumbra: revision of a concept. Cell Mol Neurobiol. 1998;18:621-638.
7. Heiss WD, Huber M, Fink G, Herholz K, Pietrzyk U, Wagner R, Wienhard K. Progressive derangement of periinfarct viable tissue in ischemic stroke. J Cereb Blood Flow Metab. 1992;12:193-203.
8. 2O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy. Stroke. 2000;31:366-369.
9. Heiss WD, Kracht LW, Thiel A, Grond M, Pawlik G. Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia. Brain. 2001;124:20-29.
10. Heiss WD, Graf R, Wienhard K, Lottgen J, Saito R, Fujita T, Rosner G, Wagner R. Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats. J Cereb Blood Flow Metab. 1994;14:892-902.
11. Heiss WD, Graf R. The ischemic penumbra. Curr Opin Neurology. 1994;7:11-19.
12. Baron JC. Mapping the ischemic penumbra with PET: implications for acute stroke treatment. Cerebrovasc Dis. 1999;9:193-201.
13. Karonen JA, Vanninen RL, Yawu L, Østergaard L, Kuikka JT, Nuutinen J, Vanninen EJ, Partanen PLK, Vainio PA, Korhonen K, et al. Combined diffusion and perfusion MRI with correlation to single-photon emission CT in acute ischemic stroke: ischemic penumbra predicts infarct growth. Stroke. 1999;30:1583-1590.
14. Beaulieu C, de Crespigny A, Tong DC, Moseley ME, Albers GW, Marks MP. Longitudinal magnetic resonance imaging study of perfusion and diffusion in stroke: evolution of lesion volume and correlation with clinical outcome. Ann Neurol. 1999;46:568-578.
15. Neumann-Haefelin T, Wittsack H-J, Wenserski F, Siebler M, Seitz RJ, Mödder U, Freund H-J. Diffusion- and perfusion-weighted MRI: the DWI/PWI mismatch region in acute stroke. Stroke. 1999;30:1591-1597.
16. Heiss WD, Grond M, Thiel A, Stockhausen H-M, Rudolf J, Ghaemi M, Löttgen J, Stenzel C, Pawlik G. Tissue at risk of infarction rescued by early reperfusion: a positron emission tomography study in systemic recombinant tissue plasminogen activator thrombolysis of acute stroke. J Cereb Blood Flow Metab. 1998;18:1298-1307.
17. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581-1587.
18. Furlan AJ, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, for the PROACT Investigators. Intra-arterial prourokinase for acute ischemic stroke: the PROACT II study: a randomized controlled trial. JAMA. 1999;282:2003-2011.
19. Wintermark M, Reichart M, Thiran JP, Maeder P, Chalaron M, Schnyder P, Bogousslavsky J, Meuli R. Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients. Ann Neurol. 2002;51:417-432.
20. Nighoghossian N, Hermier M, Adeleine P, Derex L, Dugor JF, Philippeau F, Ylmaz H, Honnorat J, Dardel P, Berthezene Y, et al. Baseline magnetic resonance imaging parameters and stroke outcome in patients treated by intravenous tissue plasminogen activator. Stroke. 2003;34:458-463.
21. Marler JR, Tilley BC, Lu M, Brott TG, Lyden PC, Grotta JC, Broderick JP, Levine SR, Frankel MP, Horowitz SH, et al, for the NINDS rt-PA Stroke Study Group. Early stroke treatment associated with better outcome: the NINDS rt-PA Stroke Study. Neurology. 2000;55:1649-1655.
22. Firlik AD, Rubin G, Yonas H, Wechsler LR. Relation between cerebral blood flow and neurologic deficit resolution in acute ischemic stroke. Neurology. 1998;51:177-182.
23. Kaufmann AM, Firlik AD, Fukui MB, Wechsler LR, Jungries CA, Yonas H. Ischemic core and penumbra in human stroke. Stroke. 1999;30:93-99.
24. Rubin G, Levy EL, Scarrow AM, Firlik AD, Karakus A, Wechsler L, Jungreis CA, Yonas H. Remote effects of acute ischemic stroke: a xenon CT cerebral blood flow study. Cerebrovasc Dis. 2000;10:221-228.
25. Yonas H, Grundy B, Gur D, Shabason L, Wolfson SK Jr, Cook EE. Side effects of xenon inhalation. J Comp Assist Tomogr. 1981;5:591-592.