Role of factor V Leiden and prothrombin 20210A in patients with retinal artery occlusion

Eye

Volumn 17, Issue 6, 2003, Pages 731-734

  Weger, Martin ^a   Renner, W ^a   Pinter, O ^a   Stanger, O ^a   Temmel, W ^a   Fellner, P ^a   Schmut, O ^a   Haas, A ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Factor V Leiden; Prothromcin 20210A; Retinal artery occlusion; Risk factor

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; INSULIN; PROTHROMBIN;

ADULT; AGE DISTRIBUTION; AGED; ALLELE; ANAMNESIS; ARTICLE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; GENETIC VARIABILITY; HEART INFARCTION; HETEROZYGOSITY; HIGH RISK PATIENT; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OPHTHALMOSCOPY; PATHOGENESIS; POLYMERASE CHAIN REACTION; PREVALENCE; RETINA ARTERY OCCLUSION; RETROSPECTIVE STUDY; SEX RATIO; STATISTICAL ANALYSIS;

EID: 0141516632     PISSN: 0950222X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.eye.6700495     Document Type: Article

References (27)

1. Blice JB, Brown GC. Retinal vascular occlusive disease. In: Spaide RF (ed). Diseases of the Retina and Vitreous. WB Saunders: Philadelphia, 1999, pp 109-127.
2. Brown GC. Retinal artery occlusive diseases. In: Guyer DR, Yanuzzi LA, Chang S, Shields YA, Green WR (eds). Retina - Vitreous - Macula. WB Saunders: Philadelphia, 1999, pp 271-285.
3. Cahill M, Karabatzaki M, Meleady R, Refsum H, Ueland P, Shields D et al. Raised plasma homocysteine as a risk factor for retinal vascular occlusive disease. Br J Ophthalmol 2000; 84: 154-157.
4. Weger M, Stanger O, Deutschmann H, Leitner FJ, Renner W, Schmut O et al. The role of hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with retinal artery occlusion. Am J Ophthalmol 2002; 134: 57-61.
5. Lane DA, Grant PJ. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood 2000; 95: 1517-1532.
6. Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med 2001; 344: 1222-1231.
7. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67.
8. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-3703.
9. Rosendaal FR, Siscovick DS, Schwartz SM, Beverly RK, Psaty BM, Longstreth Jr WT et al. Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women. Blood 1997; 89: 2817-2821.
10. Rosendaal FR, Siscovick DS, Schwartz SM, Psaty BM, Raghunathan TE, Vos HL. A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women. Blood 1997; 90: 1747-1750.
11. Doggen CJ, Cats VM, Bertina RM, Rosendaal FR. Interaction of coagulation defects and cardiovascular risk factors: increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A. Circulation 1998; 97: 1037-1041.
12. Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995; 332: 912-917.
13. Emmerich J, Poirier O, Evans A, Marques-Vidal P, Arveiler D, Luc G et al. Myocardial infarction, Arg506 to Gln factor V mutation, and activated protein C resistance. Lancet 1995; 345: 321.
14. Kontula K, Ylikorkala A, Miettinen H, Vuorio A, Kauppinen-Makelin R, Hamalainen L et al. Arg506Gln factor V mutation (factor V Leiden) in patients with ischaemic cerebrovascular disease and survivors of myocardial infarction. Thromb Haemost 1995; 73: 558-560.
15. De Stefano V, Chiusolo P, Paciaroni K, Casorelli I, Rossi E, Molinari M et al. Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischaemic disease in young patients. Blood 1998; 91: 3562-3565.
16. Ridker PM, Hennekens CH, Miletich JP. G20210A mutation in prothrombin gene and risk of myocardial infarction stroke, and venous thrombosis in a large cohort of US men. Circulation 1999; 99: 999-1004.
17. Larsson J. Central retinal artery occlusion in a patient homozygous for factor V Leiden. Am J Ophthalmol 2000; 129: 816-817.
18. Talmon T, Scharf J, Mayer E, Lanir N, Miller B, Brenner B. Retinal artery occlusion in a child with factor V Leiden and thermolabile methylene tetrahydrofoalte reductase mutations. Am J Ophthalmol 1997; 124: 689-691.
19. Tayyanipour R, Pulido JS, Postel EA, Lipkowitz JL, Pisciotta A, Braza E. Arterial vascular occlusion associated with factor V Leiden gene mutation. Retina 1998; 18: 376-377.
20. Dhar-Munshi S, Ayliffe WH, Jayne D. Branch retinal arteriolar occlusion associated with familial factor V Leiden polymorphism and positive rheumatoid factor. Arch Ophthalmol 1999; 117: 971-973.
21. Greiner K, Peetz D, Winkgen A, Prellwitz W, Pfeiffer N, Hafner G. Genetic thrombophilia in patients with retinal vascular occlusion. Int Opthalmol 1999; 23: 155-160.
22. Salomon O, Huna-Baron R, Moisseiev J, Rosenberg N, Rubovitz A, Steinberg DM et al. Thrombophilia as a cause for central and branch retinal artery occlusion in patients without an apparent embolic source. Eye 2001; 15: 511-514.
23. Chak M, Wallace GR, Graham EM, Stanford MR. Thrombophilia: genetic polymorphisms and their association with retinal vascular occlusive disease. Br J Ophthalmol 2001; 85: 883-886.
24. Dahlbäck B. Resistance to activated protein C caused by factor VR506Q mutation is a common risk factor for venous thrombosis. Thromb Haemost 1997; 78: 483-488.
25. Sagripanti A, Romani A, Ferretti A, Ragone MC, Baicchi U, Carpi A et al. Blood coagulation parameters in retinal arterial occlusion. Graefes Arch Clin Exp Ophthalmol 1999; 237: 480-483.
26. Harding JJ. Recent studies of risk factors and protective factors for cataract. Curr Opin Ophthalmol 1997; 8: 46-49.
27. Donnelly CA, Seth J, Clayton RM, Phillips CI, Cuthbert J, Prescott RJ. Some blood plasma constituents correlate with human cataract. Br J Ophthalmol 1995; 79: 1036-1041.