Zinc accumulation in N-methyl-N-nitrosourea-induced rat mammary tumors is accompanied by an altered expression of ZnT-1 and metallothionein

Experimental Biology and Medicine

Volumn 228, Issue 6, 2003, Pages 689-696

  Lee, R ^a   Woo, W ^a   Wu, B ^a   Kummer, A ^a   Duminy, H ^a   Xu, Z ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Mammary tumorogenesis; Metallothionein; Nramp2; Zinc; ZnT 1; ZnT 4

Indexed keywords

CARRIER PROTEIN; MESSENGER RNA; METALLOTHIONEIN; METHYLNITROSOUREA; PROTEIN ZNT 1; UNCLASSIFIED DRUG; ZINC; CATION TRANSPORT PROTEIN; IRON BINDING PROTEIN; MEMBRANE PROTEIN; PRIMER DNA; SLC30A1 PROTEIN, HUMAN; SLC30A1 PROTEIN, MOUSE; SLC30A1 PROTEIN, RAT; SLC30A4 PROTEIN, HUMAN; SLC30A4 PROTEIN, RAT; SOLUTE CARRIER FAMILY 11 (PROTON COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST TUMOR; CELL PROLIFERATION; CONTROLLED STUDY; DRY WEIGHT; FEMALE; IMMUNOCYTOCHEMISTRY; MINERAL BALANCE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RAT; TISSUE LEVEL; TUMOR GROWTH; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; EXPERIMENTAL NEOPLASM; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALIA; RODENTIA;

ANIMALS; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; DNA PRIMERS; FEMALE; IRON-BINDING PROTEINS; MAMMARY NEOPLASMS, EXPERIMENTAL; MEMBRANE PROTEINS; METALLOTHIONEIN; METHYLNITROSOUREA; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE DISTRIBUTION; ZINC;

EID: 0141513734     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Mills BJ, Broghamer WL, Higgins PJ, Lindeman RD. Inhibition of tumor growth by zinc depletion of rats. J Nutr 114:746-752, 1984.
2. DeWys W, Pories WJ. Inhibition of a spectrum of animal tumors by dietary zinc deficiency. J Natl Cancer Inst 48:375-381, 1972.
3. Takeda A, Goto K, Okada S. Zinc depletion suppresses tumor growth in mice. Bio Trace Element Res 59:23-29, 1997.
4. McQuitty JT, DeWys WD, Monaco L, Strain WH, Rob CG, Apgar J, Pories WJ. Inhibition of tumor growth by dietary zinc deficiency. Cancer Res 30:1387-1390, 1970.
5. DeWys W, Pories WJ, Richter MC, Strain WH. Inhibition of Walker 256 carcinosarcoma growth by dietary zinc deficiency. Proc Soc Exp Biol Med 135:17-22, 1970.
6. Santoliquido PM, Southwick HW, Olwin JH. Trace metal levels in cancer of the breast. Surg Gynecol Obstet 142:65-70, 1976.
7. Margalioth EJ, Schenker JG, Chevion M. Copper and zinc levels in normal and malignant tissues. Cancer 52:868-872, 1983.
8. Borella P, Bargellini A, Caselgrandi E, Piccinini L. Observations on the use of plasma, hair and tissue to evaluate trace element status in cancer. J Trace Elements Med Biol 11:162-165, 1997.
9. Mulay IL, Roy R, Knox BE, Shur NH, Delaney WE. Trace metal analysis of cancerous and non-cancerous human tissues. J Natl Cancer Inst 47:1-13, 1971.
10. Rizk SL, Sky-Peck HH. Comparison between concentrations of trace elements in normal and neoplastic human breast tissue. Cancer Res 44:5390-5394, 1984.
11. Ng K-H, Bradley DA, Looi L-M, Mahmood CS, Wood AK. Differentiation of elemental composition of normal and malignant breast tissue by instrumental neutron activation analysis. Appl Radiat Isot 44:511-516, 1993.
12. van Rig AM, Pories WJ. Zinc and tumor growth. In: Sigel H, Ed. Metal Ions in Biological Systems. New York: Marcel Dekker, pp207-251, 1980.
13. Cooper GM. Classification and development of neoplasms. In Cooper GM, Ed. Elements of Human Cancer. Boston: Jones and Barlett Publishers, p20, 1992.
14. Walsh CT, Sandstead HH, Prasad AS, Newberne PM, Fraker PJ. Zinc: health effects and research priorities for the 1990s. Environ Health Perspect 102(Suppl 2):5-46, 1994.
15. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482-488, 1997.
16. Gaither LA, Eide DJ. Eukaryotic zinc transporters and their regulation. BioMetals 14:251-270, 2001.
17. Palmiter RD, Findley SD. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J 14:639-649, 1995.
18. Palmiter RD, Cole TB, Findley SD. ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J 15:1784-1791, 1996.
19. Palmiter RD, Cole TB, Quaife CJ, Findley SD. ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci U S A 93:14934-14939, 1996.
20. Huang L, Gitschier J. A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nature 17:292-297, 1997.
21. Kambe T, Narita H, Yamaguchi-Iwai Y, Hirose J, Amano T, Sugiura N, Sasaki R, Mori K, Iwanaga T, Nagao M. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. J Biol Chem 277:19049-19055, 2002.
22. Cherian MG, Chan HM. Biological functions of metallothionein: a review. In: Suzuki KT, Imura N, Kimura M, Eds. Metallothionein III: Biological Roles and Medical Implications. Berlin: Birkhauser Verlag, pp87-109, 1993.
23. Chesters JK, Petrie L, Lipson KE. Two zinc-dependent steps during G1 to S phase transition. J Cell Physiol 155:445-451, 1993.
24. Prasad AS, Beck FW, Endre L, Handschu W, Kukuruga M, Kumar G. Zinc deficiency affects cell cycle and deoxythymidine kinase gene expression in HUT-78 cells. J Lab Clin Med 128:51-60, 1996.
25. Paski S, Xu Z. Labile intracellular zinc is associated with 3T3 cell growth. J Nutr Biochem 12:655-661, 2001.
26. Russo J, Gusterson BA, Rogers AE, Russo IH, Wellings SR, van Zwieten MJ. Comparative study of human and rat mammary tumorigenesis. Lab Invest 62:244-278, 1990.
27. Gould MN. Rodent models for the study of etiology, prevention and treatment of breast cancer. Semin Cancer Biol 6:147-152, 1995.
28. Nandi S, Guzman RC, Yang J. Hormones and mammary carcinogenesis in mice, rats and humans: a unifying hypothesis. Proc Natl Acad Sci U S A 92:3650-3657, 1995.
29. Thompson HJ, Adlakha H. Dose-responsive induction of mammary glands carcinomas by the intraperitoneal injection of 1-methyl-1-nitrosourea. Cancer Res 51:3411-3415, 1991.
30. Clegg MS, Keen CL, Lonnerdal B, Hurley LS. Influence of ashing techniques on the analysis of trace elements in animal tissue. Biol Trace Element Res 3:107-115, 1981.
31. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. Anal Biochem 193:265-275, 1951.
32. Folch J, Lees M, Sloanestanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509, 1957.
33. Eaton DL, Total BF. Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol Appl Pharmacol 66:134-142, 1982.
34. Eaton DL, Cherian MG. Determination of metallothionein in tissues by cadmium-hemoglobin affinity assay. In: Riordan JF, Vallee BL, Eds. Methods in Enzymology. New York: Academic Press, Part B205, pp83-88, 1991.
35. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987.
36. Clifford KS, MacDonald MJ. Survey of mRNAs encoding zinc transporters and other metal complexing proteins in pancreatic islets of rats from birth to adulthood: similar patterns in the Sprague-Dawley and Wistar BB strains. Diabetes Res Clinical Practice 49:77-85, 2000.
37. Mahnke A, Strotkamp D, Roos PH, Hanstein WG, Chabot GG, Nef P. Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. Arch Biochem Biophys 337:62-68, 1997.
38. Moffatt P, Denizeau F. Metallothionein in physiological and physiopathological processes. Drug Metab Rev 29:261-307, 1997.
39. Bremner I. Nutritional and physiologic significance of metallothionein. In: Riordan JF, Vallee BL, Eds. Methods in Enzymology. New York: Academic Press, Part B205, pp25-35, 1991.
40. Menard P, McCormick CC, Cousins RJ. Regulation of intestinal metallothionein biosynthesis in rats by dietary zinc. J Nutr 111:1353-1361, 1981.
41. Richards MP, Cousins RJ. Metallothionein and its relationship to the metabolism of dietary zinc in rats. J Nutr 106:1591-1599, 1976.
42. 2+ requirement for DNA synthesis by 3T3 cells. Exp Cell Res 184:499-508, 1989.
43. Williams RB, Chesters JK. The effects of early zinc deficiency on DNA and protein synthesis in the rat. Br J Nutr 24:1053-1059, 1970.
44. Cherian MG, Huang PC, Klaassen CD, Liu Y, Longfellow DG, Waalkers MP. National Cancer Institute Workshop on the possible roles of metallothionein in carcinogenesis. Cancer Res 53:922-925, 1993.
45. Goulding H, Jasen B, Pereira H, Reid A, Galea M, Bell JA, Elston CW, Robertson JF, Blamey RW, Nicholson RA, Schmid KW, Ellis IO. Metallothionein expression in human breast cancer. Br J Cancer 72:968-972, 1995.
46. Jin R, Bay BH, Chow VTK, Tan PH. Metallothionein 1F mRNA expression correlates with histological grade in breast carcinoma. Breast Cancer Res Trea 66:265-272, 2001.
47. Jin R, Chow VTK, Tan PH, Dheen ST, Duan W, Bay BH. Metallothionein 2A expression is associated with cell proliferation in breast cancer. Carcinogenesis 23:81-86, 2002.
48. Schmid KW, Ellis IO, Gee JMW, Darke BM, Lees WE, Kay J, Cryer A, Stark JM, Hittmair A, Ofner D, Dunser M, Margreiter R, Daxenbichler G, Nicholson RI, Bier B, Bocker W, Jasani B. Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast. Virchows Arch A Pathol Anat 422:153-159, 1993.
49. Sens MA, Somji S, Garrett SH, Beall CL, Sens DA. Metallothionein isoform 3 overexpression is associated with breast cancer having a poor prognosis. Am J Pathol 159:21-26, 2001.
50. Zhang R, Zhang H, Wei H, Luo X. Expression of metallothionein in invasive ductal breast cancer in relation to prognosis. J Environ Pathol Toxicol Oncol 19:95-97, 2000.
51. Grogan TM, Lippman SM, Spier CM, Slymen DJ, Rybski JA, Rangel CS, Richter LC, Miller TP. Independent prognostic significance of a nuclear proliferation antigen in diffuse large cell lymphomas as determined by the monoclonal antibody Ki-67. Blood 71:1157-1160, 1988.
52. Cherian MG, Howell SB, Imura N, Klaassen CD, Koropatnick J, Lazo JS, Waaljes MP. Role of metallothionein in carcinogenesis. Toxicol Appl Pharmacol 126:1-5, 1994.
53. Adbel-Mageed A, Agrawal KC. Antisense down0regulation of metallothionein induces growth arrest and apoptosis in human breast cancer carcinoma cells. Cancer Gene Ther 4:199-207, 1997.
54. Philcox JC, Tilley MH, Coyle P, Rofe AM. Metallothionein and zinc homeostasis during tumor progression. Biol Trace Element Res 40:295-305, 1994.
55. Liuzzi JP, Blanchard RK, Cousins RJ. Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats. J Nutr 131:46-52, 2001.