Valproate disrupts regulation of inositol responsive genes and alters regulation of phospholipid biosynthesis

Molecular Microbiology

Volumn 49, Issue 6, 2003, Pages 1595-1604

  Ju, Shulin ^a   Greenberg, Miriam L ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE DIPHOSPHATE DIGLYCERIDE; INOSITOL; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PHOSPHOLIPID; VALPROIC ACID;

ARTICLE; CELL GROWTH; CHO 1 GENE; CONTROLLED STUDY; DRUG EXPOSURE; GENE; GENE EXPRESSION; INO 1 GENE; INO 2 GENE; INTRACELLULAR SPACE; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; VPA GENE;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0141454852     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2003.03641.x     Document Type: Article

References (31)

1. Ashburner, B.P., and Lopes, J.M. (1995) Regulation of yeast phospholipid biosynthetic gene expression in response to inositol involves two superimposed mechanisms. Proc Natl Acad Sci USA 92: 9722-9726.
2. Berridge, M.J., Downes, C.P., and Hanley, M.R. (1989) Neural and developmental actions of lithium: a unifying hypothesis. Cell 59: 411-419.
3. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
4. Carman, G.M., and Bae-Lee, M. (1992) Phosphatidylserine synthase from yeast. Methods Enzymol 209: 298-305.
5. Carman, G.M., and Henry, S.A. (1999) Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes. Prog Lipid Res 38: 361-399.
6. Ding, D., and Greenberg, ML. (2003) Lithium and valproate decrease the membrane phosphatidylinositol/phosphatidylcholine ratio. Mol Microbiol 47: 373-381.
7. Elion, E.A., and Warner, J.R. (1984) The major promoter element of rRNA transcription in yeast lies 2 kb upstream. Cell 39: 663-673.
8. Fisher, S.K., Novak, J.E., and Agranoff, B.W. (2002) Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance. J Neurochem 82: 736-754.
9. Greenberg, M.L., and Lopes, J.M. (1996) Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae. Microbiol Rev 60: 1-20.
10. Greenberg, M.L., Hubbell, S., and Lam, C. (1988) Inositol regulates phosphatidylglycerolphosphate synthase expression in Saccharomyces cerevisiae. Mol Cell Biol 8: 4773-4779.
11. Griac, P., Swede, M.J., and Henry, S.A. (1996) The role of phosphatidylcholine biosynthesis in the regulation of the INO1 gene of yeast. J Biol Chem 271: 25692-25698.
12. Gurvich, N., and Klein, P.S. (2002) Lithium and valproic acid: parallels and contrasts in diverse signaling contexts. Pharmacol Ther 96: 45-66.
13. Jiang, F., Ryan, M.T., Schlame, M., Zhao, M., Gu, Z., Klingenberg, M., et al. (2000) Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J Biol Chem 275: 22387-22394.
14. Kato, T., and Kato, N. (2000) Mitochondrial dysfunction in bipolar disorder. Bipolar Disord 2: 180-190.
15. Kelley, M.J., Bailis, A.M., Henry, S.A., and Carman, G.M. (1988) Regulation of phospholipid biosynthesis in Saccharomyces cerevisiae by inositol. Inositol is an inhibitor of phosphatidylserine synthase activity. J Biol Chem 263: 18078-18085.
16. Kinney, A.J., and Carman, G.M. (1988) Phosphorylation of yeast phosphatidylserine synthase in vivo and in vitro by cyclic AMP-dependent protein kinase. Proc Natl Acad Sci USA 85: 7962-7966.
17. Koshkin, V., and Greenberg, M.L. (2000) Oxidative phosphorylation in cardiolipin-lacking yeast mitochondria. Biochem J 347: 687-691.
18. Koshkin, V., and Greenberg, M.L. (2002) Cardiolipin prevents rate-dependent uncoupling and provides osmotic stability in yeast mitochondria. Biochem J 364: 317-322.
19. Leray, C., Pelletier, X., Hemmendinger, S., and Cazenave, J.P. (1987) Thin-layer chromatography of human platelet phospholipids with fatty acid analysis. J Chromatogr 420: 411-416.
20. Maslanski, J.A., and Busa, W.B. (1990) A sensitive and specific mass assay for myo-inositol and inositol phosphate. In Methods in Inositide Research. Irvine, R.F. (ed.). New York: Raven Press, pp. 113-126.
21. Murray, M., and Greenberg, M.L. (1997) Regulation of inositol monophosphatase in Saccharomyces cerevisiae. Mol Microbiol 25: 541-546.
22. Murray, M., and Greenberg, M.L. (2000) Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate. Mol Microbiol 36: 651-661.
23. O'Donnell, T., Rotzinger, S., Nakashima, T.T., Hanstock, C.C., Ulrich, M., and Silverstone, P.H. (2000) Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain. Brain Res 880: 84-91.
24. Phiel, C.J., Zhang, F., Huang, E.Y., Guenther, M.G., Lazar, M.A., and Klein, P.S. (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276: 36734-36741.
25. Schlame, M., Rua, D., and Greenberg, M.L. (2000) The biosynthesis and functional role of cardiolipin. Prog Lipid Res 39: 257-288.
26. Sreenivas, A., Villa-Garcia, M.J., Henry, S.A., and Carman, G.M. (2001) Phosphorylation of the yeast phospholipid synthesis regulatory protein Opi1p by protein kinase C. J Biol Chem 276: 29915-29923.
27. Vaden, D.L., Ding, D., Peterson, B., and Greenberg, M.L. (2001) Lithium and valproate decrease inositol mass and increase expression of the yeast INO1 and INO2 genes for inositol biosynthesis. J Biol Chem 276: 15466-15471.
28. Vadnal, R., and Parthasarathy, R. (1995) Myo-inositol monophosphatase: diverse effects of lithium, carbamazepine, and valproate. Neuropsychopharmacology 12: 277-285.
29. Weissman, M.M., Leaf, P.J., Tischler, G.L., Karno, M., Bruce, M.L., and Florio, L.P. (1988) Affective disorders in five United States communities. Psychol Med 18: 141-153.
30. York, J.D., Guo, S., Odom, A.R., Spiegelberg, B.D., and Stolz, L.E. (2001) An expanded view of inositol signaling. Adv Enzyme Regul 41: 57-71.
31. Zhong, Q., and Greenberg, M.L. (2003) Regulation of phosphatidylglycerolphosphate synthase by inositol in Saccharomyces cerevisiae is not at the level of PGS1 mRNA abundance. J Biol Chem (in press).