Permeation, metabolism and site of action concentration of nicotinic acid derivatives in human skin: Correlation with topical pharmacological effect

European Journal of Pharmaceutical Sciences

Volumn 20, Issue 2, 2003, Pages 181-195

  Müller, Beat ^a   Kasper, Marlis ^a   Surber, Christian ^b   Imanidis, Georgios ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

In vivo pharmacological dose effect relationship; Metabolism; Nicotinic acid esters; Site of action drug concentration; Topical application; Transdermal permeation

Indexed keywords

BLOOD; INORGANIC ACIDS; METABOLISM; SKIN;

BLOOD CAPILLARIES;

DRUG PRODUCTS;

1 NAPHTHYL ACETATE ESTERASE; NICOTINIC ACID DERIVATIVE; NICOTINIC ACID HEXYL ESTER; NICOTINIC ACID METHYL ESTER; PERIPHERAL VASODILATING AGENT;

AREA UNDER THE CURVE; ARTICLE; BASAL CELL; CADAVER; CAPILLARY; COLOR; CONTROLLED STUDY; CORRELATION ANALYSIS; DERMIS; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG MECHANISM; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENCY; DRUG TRANSPORT; ENZYME ACTIVITY; EPIDERMIS; ERYTHEMA; FEMALE; FOREARM; HEALTH STATUS; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERTHERMIC THERAPY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIGHT; LIPOPHILICITY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SKIN PERMEABILITY; TECHNIQUE; VOLUNTEER;

EID: 0141447812     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(03)00179-9     Document Type: Article

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