Antimicrobial peptides: Potential use in skin infections

American Journal of Clinical Dermatology

Volumn 4, Issue 9, 2003, Pages 591-595

  Ulvatne, Hilde ^a,b  

^a UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; ANTIINFECTIVE AGENT; BETA DEFENSIN; CECROPIN A; CECROPIN P1; GRAMICIDIN 8; GRAMICIDIN DERIVATIVE; INDOLICIDIN; MAGAININ 2; MBI 226; MBI 549AN; METICILLIN; PEPTIDE DERIVATIVE; POLYMYXIN B; PROTEGRIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; BACTERIAL INFECTION; CATHETER INFECTION; CLINICAL TRIAL; CREAM; DIABETIC FOOT; DRUG COST; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; ENTEROCOCCUS; HUMAN; INFECTION PREVENTION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PEPTIDE ANALYSIS; PRIORITY JOURNAL; REVIEW; SKIN INFECTION;

ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; ENTEROCOCCUS; HUMANS; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; SKIN DISEASES, INFECTIOUS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VANCOMYCIN RESISTANCE;

EID: 0043239019     PISSN: 11750561     EISSN: None     Source Type: Journal    
DOI: 10.2165/00128071-200304090-00001     Document Type: Review

References (49)

1. Walsh C. Molecular mechanisms that confer antibacterial drug resistance. Nature 2000; 406: 775-81
2. World Health Organization. World Health Organization website [online]. Available from: URL: http://www.who.int [Accessed 2003 Aug 1]
3. Hancock RE, Falla T, Brown M. Cationic bactericidal peptides. Adv Microb Physiol 1995; 37: 135-75
4. Risso A. Leukocyte antimicrobial peptides: multifunctional effector molecules of innate immunity. J Leukoc Biol 2000; 68: 785-92
5. Hancock RE, Chapple DS. Peptide antibiotics. Antimicrob Agents Chemother 1999; 43: 1317-23
6. Boman HG. Innate immunity and the normal microflora. Immunol Rev 2000; 173: 5-16
7. Hancock RE, Lehrer R. Cationic peptides: a new source of antibiotics. Trends Biotechnol 1998; 16: 82-8
8. Hancock RE, Diamond G. The role of cationic antimicrobial peptides in innate host defences. Trends Microbiol 2000; 8: 402-10
9. Lowenberger C, Charlet M, Vizioli J, et al. Antimicrobial activity spectrum, cDNA cloning, and mRNA expression of a newly isolated member of the cecropin family from the mosquito vector Aedes aegypti. J Biol Chem 1999; 274: 20092-7
10. Lee JY, Boman A, Sun CX, et al. Antibacterial peptides from pig intestine: isolation of a mammalian cecropin. Proc Natl Acad Sci U S A 1989; 86: 9159-62
11. Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A 1987; 84: 5449-53
12. Selsted ME, Harwig SS, Ganz T, et al. Primary structures of three human neutrophil defensins. J Clin Invest 1985; 76: 1436-9
13. Bals R, Wang X, Wu Z, et al. Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 1998; 102: 874-80
14. Storici P, Zanetti M. A novel cDNA sequence encoding a pig leukocyte antimicrobial peptide with a cathelin-like pro-sequence. Biochem Biophys Res Commun 1993; 196: 1363-8
15. Selsted ME, Novotny MJ, Morris WL, et al. Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J Biol Chem 1992; 267: 4292-5
16. Ganz T, Selsted ME, Szklarek D, et al. Defensins: natural peptide antibiotics of human neutrophils. J Clin Invest 1985; 76: 1427-35
17. Daher KA, Selsted ME, Lehrer RI. Direct inactivation of viruses by human granulocyte defensins. J Virol 1986; 60: 1068-74
18. Lehrer RI, Ganz T, Szklarek D, et al. Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. J Clin Invest 1988; 81: 1829-35
19. Goldman MJ, Anderson GM, Stolzenberg ED, et al. Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 1997; 88: 553-60
20. Gropp R, Frye M, Wagner TO, et al. Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy. Hum Gene Ther 1999; 10: 957-64
21. Harder J, Bartels J, Christophers E, et al. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 2001; 276: 5707-13
22. Cirioni O, Giacometti A, Barchiesi F, et al. In-vitro activity of lytic peptides, inhibitors of ion transport systems and ionophorous antibiotics against Pneumocystis carinii. J Antimicrob Chemother 1998; 42: 141-5
23. Giacometti A, Cirioni O, Barchiesi F, et al. Antimicrobial activity of polycationic peptides. Peptides 1999; 20: 1265-73
24. Bechinger B. The structure, dynamics and orientation of antimicrobial peptides in membranes by multidimensional solid-state NMR spectroscopy. Biochim Biophys Acta 1999; 1462: 157-83
25. Shai Y. Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Biochim Biophys Acta 1999:, 1462: 55-70
26. Boman HG, Agerberth B, Boman A. Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infect Immun 1993; 61: 2978-84
27. Kragol G, Lovas S, Varadi G, et al. The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding. Biochemistry 2001; 40: 3016-26
28. Diamond G. Natures antibiotics: the potential of antimicrobial peptides as new drugs. Biologist (London) 2001; 48: 209-12
29. Cole AM, Ganz T. Human antimicrobial peptides: analysis and application. Biotechniques 2000; 29: 822-6, 828, 830-1
30. Miyasaki KT, Lehrer RI. Beta-sheet antibiotic peptides as potential dental therapeutics. Int J Antimicrob Agents 1998; 9: 269-80
31. Giacometti A, Cirioni O, Barchiesi F, et al. In-vitro activity and killing effect of polycationic peptides on methicillin-resistant Staphylococcus aureus and interactions with clinically used antibiotics. Diagn Microbiol Infect Dis 2000; 38: 115-8
32. Giacometti A, Cirioni O, Del Prete MS, et al. Comparative activities of polycationic peptides and clinically used antimicrobial agents against multidrug-resistant nosocomial isolates of Acinetobacter baumannii. J Antimicrob Chemother 2000; 46: 807-10
33. Yan H, Hancock RE. Synergistic interactions between mammalian antimicrobial defense peptides. Antimicrob Agents Chemother 2001; 45: 1558-60
34. Giacometti A, Cirioni O, Del Prete MS, et al. Combination studies between polycationic peptides and clinically used antibiotics against Gram-positive and Gram-negative bacteria. Peptides 2000; 21: 1155-60
35. Andreu D, Rivas L. Chemistry and applications of synthetic antimicrobial peptides. In: Dutton CJ, Haxell MA, McArthur HAI, et al., editors. Peptide antibioics: discovery, modes of action, and applications. New York: Marcel Dekker AG, 2002: 15-45
36. Banemann A, Deppisch H, Gross R. The lipopolysaccharide of Bordetella bronchiseptica acts as a protective shield against antimicrobial peptides. Infect Immun 1998; 66: 5607-12
37. Gunn JS, Ryan SS, Van Velkinburgh JC, et al. Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimurium. Infect Immun 2000; 68: 6139-46
38. Peschel A, Otto M, Jack RW, et al. inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. J Biol Chem 1999; 274: 8405-10
39. Tossi A, Sandri L, Giangaspero A. Amphipathic, alpha-helical antimicrobial peptides. Biopolymers 2000; 55: 4-30
40. Zanetti M, Gennaro R, Skerlavaj B, et al. Cathelicidin peptides as candidates for a novel class of antimicrobials. Curr Pharm Des 2002; 8: 779-93
41. Strom MB, Rekdal O, Svendsen JS. Antimicrobial activity of short arginine- and tryptophan-rich peptides. J Pept Sci 2002; 8: 431-7
42. Wade D, Boman A, Wahlin B, et al. All-D amino acid-containing channel-forming antibiotic peptides. Proc Natl Acad Sci U S A 1990; 87: 4761-5
43. Bessalle R, Kapitkovsky A, Gorea A, et al. All-D-magainin: chirality, antimicrobial activity and proteolytic resistance. FEBS Lett 1990; 274: 151-5
44. Porter EA, Wang X, Lee HS, et al. Non-haemolytic beta-amino-acid oligomers. Nature 2000; 404: 565
45. Genaera Corporation. Other programs [online]. Available from URL: http://www.genaera.com/otherprograms.htm [Accessed 2003 July 30]
46. Micrologix Biotech. MBI 226: prevention of CVC-related bloodstream infections. Available from: URL: http://www.mbiotech.com/prod_226.html [Accessed 2003 July 30]
47. Micrologix Biotech. MBI 594AN: treatment of acne. Available from: URL: http://www.mbiotech.com/prod_594.html [Accessed 2003 July 30]
48. Steinstraesser L, Klein RD, Aminlari A, et al. Protegrin-1 enhances bacterial killing in thermally injured skin. Crit Care Med 2001; 29: 1431-7
49. Intrabiotics. Iseganan [online]. Available from: URL: http://www.intrabiotics.com/products [Accessed 2003 Aug 6]