1,2-Dihydroisoquinoline-N-acetic acid derivatives as new carriers for brain-specific delivery II: Delivery of phenethylamine as model drug

Archiv der Pharmazie

Volumn 336, Issue 4-5, 2003, Pages 258-263

  Mahmoud, Sahar ^a   Sheha, Mahmoud ^a   Aboul Fadl, Tarek ^a   Farag, Hassan ^a  

^a Assiut University   (Egypt)

Author keywords

Brain specific delivery; Dihydroisoquinoline; In vitro Stability; In vivo Distribution

Indexed keywords

1,2 DIHYDROISOQUINOLINE N ACETIC ACID DERIVATIVE; 2 (CARBOXYMETHYL) 4 (N PHENETHYLCARBAMOYL) 1,2 DIHYDROISOQUINOLINE; 2 (ETHOXYCARBONYLMETHYL) 4 (N PHENETHYLCARBAMOYL) 1,2 DIHYDROISOQUINOLINE; 2 (ISOPROPYLOXYCARBONYLMETHYL) 4 (N PHENETHYLCARBAMOYL) 1,2 DIHYDROISOQUINOLINE; DIHYDROISOQUINOLINE NITROGEN; DRUG CARRIER; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; DRUG SYNTHESIS; DRUG TRANSPORT; DRUG URINE LEVEL; HUMAN; HUMAN CELL; HYDRATION; HYDROLYSIS; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RABBIT; TIME;

EID: 0043237308     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200300764     Document Type: Article

References (16)

1. D. J. Begley, J. Pharm. Pharmacol. 1996, 48, 136.
2. J. B. van Bree, A. G. De Boer, M. Danhof, D. D. Breimer, Pharm. World Sci. 1993, 15, 2.
3. T. Sakaeda, T. J. Siahaan, K. I. Audis, V. J. Stella, J. Drug Target. 2000, 8, 195-204.
4. A. Domb, M. Maniar, S. Bogdansky, M. Chasin, Crit. Rev. Ther. Drug Carrier Syst., 1991, 8, 1-17.
5. R. D. Egleton, T. P. Davis, Peptides 1997, 18, 1431-1439.
6. N. Bodor, Pharmazie 1997, 52, 491-494.
7. N. Bodor, Adv. Drug Deliv. Rev. 1994, 14, 157.
8. N. Bodor, H. H. Frag, J. Med. Chem. 1983, 26, 313-318.
9. N. Bodor, U. S. Pat. No. 5, 082,853 (1992)
10. N. Bodor, H. Farag, J. Pharm. Sci. 1984, 73, 385.
11. N. Bodor, H. H. Farag, M. D. Barros, W. M. Wu, P. Buchwald, L. Drug Target. 2002, 10, 63.
12. J. Keay, in Advances in Heterocyclic Chemistry, Vol. 39, (Ed.: A. Katritzky) Academic Press, Inc., New York 1986, p.33.
13. H. Schmid, P. Karrer, Helv. Chim. Acta, 1949, 32, 960.
14. P. Karrer, F. Kahnt, R. Epstein, W. Jaffe, T. Ishii, Helv. Chem. Acta 1938, 21, 223.
15. A. Nuvole, G. Paglietti, P. Sanna, R.M. Achesson, J. Chem. Res. 1984, 356.
16. M. F. Powell, J. C. Wu, T. C. Bruice, J. Am. Chem. Soc. 1984, 106, 3850.