A case control study of factors and infections associated with clinically apparent respiratory disease in UK Thoroughbred racehorses

Preventive Veterinary Medicine

Volumn 60, Issue 1, 2003, Pages 107-132

  Newton, J R ^a   Wood, J L N ^a   Chanter, N ^a  

^a ANIMAL HEALTH TRUST   (United Kingdom)

Author keywords

Inflammatory airway disease; Streptococcus zooepidemicus; Thoroughbred racehorses

Indexed keywords

ACINETOBACTER; ACTINOBACILLUS; ADENOVIRIDAE; EQUIDAE; FELIS; MYCOPLASMA; MYCOPLASMA FELIS; PASTEURELLA; RHINOVIRUS; STAPHYLOCOCCUS; STREPTOCOCCUS; STREPTOCOCCUS EQUI SUBSP. ZOOEPIDEMICUS; STREPTOCOCCUS ZOOEPIDEMICUS;

EID: 0043235726     PISSN: 01675877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5877(03)00085-0     Document Type: Article

References (57)

1. Allen, G.K., Campbell Beggs, C., Robinson, J.A., Johnson, P.J., Green, E.M., 1996. Induction of early-phase endotoxin tolerance in horses. Equine Vet. J. 28, 269-274.
2. Austin, S.M., Foreman, J.H., Hungerford, L.L., 1995. Case-control study of risk factors for development of pleuropneumonia in horses. J. Am. Vet. Med. Assoc. 207, 325-330.
3. Bailey, C.J., Reid, S.W.J., Hodgson, D.R., Rose, R.J., 1999. Impact of injuries and disease on a cohort of two- and three-year-old Thoroughbreds in training. Vet. Rec. 145, 487-493.
4. Barton, M.H., Collates, C., Moore, J.N., 1996. Endotoxin induced expression of tumour necrosis factor, tissue factor and plasminogen activator inhibitor activity by peritoneal macrophages. Equine Vet. J. 28, 382-389.
5. Blunden, A.S., Mackintosh, M.E., 1991. The microflora of the lower respiratory tract of the horse: an autopsy study. Br. Vet. J. 147, 238-250.
6. Blunden, A.S., Hannant, D., Livesay, G., Mumford, J.A., 1994. Susceptibility of ponies to infection with Streptococcus pneumoniae (capsular type 3). Equine Vet. J. 26, 22-28.
7. Burrell, M.H., 1985. Endoscopic and virological observations on respiratory disease in a group of young Thoroughbred horses in training. Equine Vet. J. 17, 99-103.
8. Burrell, M.H., Mackintosh, M.E., Taylor, C.E., 1986. Isolation of Streptococcus pneumoniae from the respiratory tract of horses. Equine Vet. J. 18, 183-186.
9. Burrell, M.H., Whitwell, K.E., Wood, J.L.N., Mumford, J.A., 1994. Pyrexia associated with respiratory disease in young Thoroughbred horses. Vet. Rec. 134, 219-220.
10. Burrell, M.H., Whitwell, K.E., Wood, J.L.N., Chanter, N., Mumford, J.A., 1996. Respiratory disease in Thoroughbred horses in training: the relationship between disease and viruses, bacteria and environment. Vet. Rec. 139, 308-313.
11. Causey, R.C., Paccamonti, D.L., Todd, W.J., 1995. Antiphagocytic properties of uterine isolates of Streptococcus zooepidemicus and mechanisms of killing in freshly obtained blood of horses. Am. J. Vet. Res. 56, 321-328.
12. Chaffin, M.K., Carter, G.K., 1993. Equine bacterial pleuropneumonia. Part I. Epidemiology, pathophysiology, and bacterial isolates. Comp. Cont. Educ. Pract. Vet. 15, 1642-1650.
13. Chanter, N., 1997. Streptococci and enterococci as animal pathogens. J. Appl. Microbiol. Symp. Suppl. 83, 100S-109S
14. Chapman, P.S., Green, C., Main, J.P.M., Taylor, P.M., Cunningham, F.M., Cook, A.J.C., Marr, C.M., 2000. Retrospective study of the relationships between age, inflammation and the isolation of bacteria from the lower respiratory tract of Thoroughbred horses. Vet. Rec. 146, 91-95.
15. Christley, R.M., Hodgson, D.R., Rose, R.J., Reid, S.W.J., Hodgson, J.L., 1999a. Comparison of bacteriology and cytology of tracheal fluid samples collected by percutaneous transtracheal aspiration or via an endoscope using a plugged, guarded catheter. Equine Vet. J. 31, 197-202.
16. Christley, R.M., Wood, J.L.N., Reid, S.W.J., Hodgson, D.R., Rose, R.J., Hodgson, J.L., 1999b. Risk factors for coughing in Thoroughbred racehorses. In: Goodall, E.A., Thrusfield, M.V. (Eds.), Proceedings of the Society for Veterinary Epidemiology and Preventive Medicine, Bristol, UK, pp. 197-210.
17. Christley, R.M., Hodgson, D.R., Rose, R.J., Wood, J.L.N., Reid, S.W.J., Whitear, K., Hodgson, J.L., 2001a. A case control study of respiratory disease in Thoroughbred racehorses in Sydney, Australia. Equine Vet. J. 33, 256-264.
18. Christley, R.M., Wood, J.L.N., Reid, S.W.J., Hodgson, D.R., Rose, R.J., Hodgson, J.L., 2001b. Coughing in Thoroughbred racehorses: risk factors and tracheal endoscopie and cytological findings. Vet. Rec. 148, 99-104.
19. Darien, B.J., Brown, C.M., Walker, R.D., Williams, M.A., Derksen, F.J., 1990. A tracheoscopic technique for obtaining uncontaminated lower airway secretions for bacteriological culture in the horse. Equine Vet. J. 22, 170-173.
20. Greenland, S., Thomas, D.C., 1982. On the need for the rare disease assumption in case-control studies. Am. J. Epidemiol. 116, 547-553.
21. Hill, A.B., 1965. The environment and disease: association or causation? Proc. R. Soc. Med. 58, 295-300.
22. Hoffman, A.M., Baird, J.D., Kloeze, H.J., Rosendal, S., Bell, M., 1992. Mycoplasma felis pleuritis in 2 show-jumper horses. Cornell Vet. 82, 155-162.
23. Hoffman, A.M., Viel, L., Juniper, E., Prescott, J.F., 1993a. Clinical and endoscopie study to estimate the incidence of distal respiratory tract infection in Thoroughbred foals on Ontario breeding farms. Am. J. Vet. Res. 54, 1602-1607.
24. Hoffman, A.M., Viel, L., Prescott, J.F., Rosendal, S., Thorsen, J., 1993b. Association of microbiologic flora with clinical, endoscopic, and pulmonary cytologic findings in foals with distal respiratory tract infection. Am. J. Vet. Res. 54, 1615-1622.
25. Hosmer, D.W., Lemeshow, S., 1989. Applied Logistic Regression. Wiley, New York, 307 pp.
26. Jeffcott, L.B., Rossdale, P.D., Freestone, J., Frank, C.J., Towers-Clarke, P.F., 1982. An assessment of wastage in Thoroughbred racing from conception to 4 years of age. Equine Vet. J. 14, 185-198.
27. Mackintosh, M.E., Grant, S.T., Burrell, M.H., 1988. Evidence for Streptococcus pneumoniae as a cause of respiratory disease in young Thoroughbred horses in training. In: Powell, D.G. (Ed.), Proceedings of the Fifth International Conference on Equine Infectious Diseases V. Karger Basel, New York, pp. 41-44.
28. Mair, T.S., Lane, J.G., 1989. Pneumonia, lung abscesses and pleuritis in adult horses: a review of 51 cases. Equine Vet. J. 21, 175-180.
29. Moore, B.R., 1996. Lower respiratory tract disease. Vet. Clin. N. Am.: Equine Pract. 12, 457-472.
30. Morley, P.S., 1995. Epidemiology of infectious upper respiratory tract disease in horses. Ph.D. Thesis. University of Saskatchewan.
31. Morley, P.S., Chirino Trejo, M., Petrie, L., Krupka, L., Schwab, M., 1996. Pericarditis and pleuritis caused by Mycoplasma felis in a horse. Equine Vet. J. 28, 237-240.
32. Mumford, J.A., Rossdale, P.D., 1980. Virus and its relationship to the 'poor performance' syndrome. Equine Vet. J. 12, 3-9.
33. Newton, J.R., Verheyen, K., Wood, J.L.N., Yates, P.J., Mumford, J.A., 1999. Equine influenza in the United Kingdom in 1998. Vet. Rec. 145, 449-452.
34. Newton, J.R., Townsend, H.G.G., Wood, J.L.N., Sinclair, R., Hannant, D., Mumford, J.A., 2000. Immunity to equine influenza: relationship of vaccine-induced antibody in young Thoroughbred racehorses to protection against field infection with influenza A/equine-2 viruses (H3N8). Equine Vet. J. 32, 65-74.
35. Ogilvie, T.H., Rosendal, S., Blackwell, T.E., Rostkowski, C.M., Julian, R.J., Ruhnke, L., 1983. Mycoplasma felis as a cause of pleuritis in horses. J. Am. Vet. Med. Assoc. 182, 1374-1376.
36. Powell, D.G., Burrows, R., Spooner, P.R., Goodridge, D., Thomson, G.R., Mumford, J., Bryans, J.T., Gerber, H., 1978. A study of infectious respiratory disease among horses in Great Britain, 1971-1976. In: Bryans, J.T., Gerber, H. (Eds.), Proceedings of the Fourth International Conference on Equine Infectious Diseases IV. Karger Basel, New York, pp. 451-459.
37. Pregibon, D., 1981. Logistic regression diagnostics. Ann. Statist. 9, 705-724.
38. Raidal, S.L., 1995. Equine pleuropneumonia. Br. Vet. J. 151, 233-262.
39. Raidal, S.L., Love, D.N., Bailey, G.D., 1997. Effect of a single bout of high intensity exercise on lower respiratory tract contamination in the horse. Aust. Vet. J. 75, 293-295.
40. Robinson, N.E., 2001. International workshop on equine chronic airway disease. Equine Vet. J. 33, 5-19.
41. Rodrigues, L., Kirkwood, B.R., 1990. Case-control designs in the study of common diseases: updates on the demise of the rare disease assumption and the choice of sampling scheme for controls. Int. J. Epidemiol. 19, 205-213.
42. Rosendal, S., Blackwell, T.E., Lumsden, J.H., Physick Sheard, P.W., Viel, L., Watson, S., Woods, P., 1986. Detection of antibodies to Mycoplasma felis in horses. J. Am. Vet. Med. Assoc. 188, 292-294.
43. Rossdale, P.D., Hopes, R., Wingfield-Digby, N.J., Offord, K., 1985. Epidemiological study of wastage among racehorses 1982 and 1983. Vet. Rec. 116, 66-69.
44. Shimada, M., Tsukada, H., Ishizuka, O., Kon, Y., Hasegawa, T., Suzuki, E., Gejyo, F., 2000. Lipopolysaccharide tolerance in relation to intrabronchial influx of neutrophils in the rat. Lung 178, 235-248.
45. Sweeney, C.R., Beech, J., Roby, K.A., 1985. Bacterial isolates from tracheobronchial aspirates of healthy horses. Am. J. Vet. Res. 46, 2562-2565.
46. Sweeney, C.R., Sweeney, R.W., Benson, C.E., 1989. Comparison of bacteria isolated from specimens obtained by the use of endoscopie guarded swabbing and percutaneous tracheal aspiration in the horse. J. Am. Vet. Med. Assoc. 195, 1225-1229.
47. Sweeney, C.R., Humber, K.A., Roby, K.A.W., 1992. Cytologic findings of tracheobronchial aspirates from 66 Thoroughbred racehorses. Am. J. Vet. Res. 53, 1172-1175.
48. Thomson, G.R., 1978. The role of equid herpesvirus 1 in acute respiratory disease of horses and the use of inactivated antigens to immunize against the infection. Ph.D. Thesis, University of London.
49. Ward, C.L., Wood, J.L.N., Houghton, S.B., Mumford, J.A., Chanter, N., 1998. Actinobacillus and Pasteurella species isolated from horses with lower airway disease. Vet. Rec. 143, 277-279.
50. White, E., Hunt, J.R., Casso, D., 1998. Exposure measurement in cohort studies: the challenges of prospective data collection. Epidemiol. Rev. 20, 43-56.
51. Whitwell, K.E., Greet, T.R.C., 1984. Collection and evaluation of tracheo-bronchial washes in the horse. Equine Vet. J. 16, 499-508.
52. Wood, J.L.N., 1999. An epidemiological investigation of respiratory disease in racehorses, Ph.D. Thesis, Open University, UK.
53. Wood, J.L.N., Chanter, N., 1994. Can washing help keep the lungs clean. Equine Vet. Educ. 6, 220-222.
54. Wood, J., Mumford, J., 1992. Epidemiology of equine influenza. Vet. Rec. 130, 126.
55. Wood, J.L.N., Burrell, M.H., Roberts, C., Shaw, Y., Chanter, N., 1993. Streptococci and Pasteurella associated with disease of the equine lower respiratory tract. Equine Vet. J. 25, 314-318.
56. Wood, J.L.N., Chanter, N., Newton, J.R., Burrell, M.H., Dugdale, D., Windsor, H.M., Windsor, G.D., Rosendal, S., Townsend, H.G.G., 1997. An outbreak of respiratory disease in racehorses associated with Mycoplasma felis infection. Vet. Rec. 140, 388-391.
57. Wood, J.L.N., Newton, J.R., Chanter, N., Townsend, H.G.G., Lakhani, K.H., Mumford, J.A., Sinclair, R., Burrell, M.H., Pilsworth, R.C., Shepherd, M., Dugdale, D., Herinckx, B.M.B., Main, J.P.M., Windsor, H., Windsor, D., 1999. A longitudinal epidemiological study of respiratory disease in racehorses: disease definitions, prevalence and incidence. In: Wernery, U., Wade, J.F., Mumford, J.A., Kaaden, O.-R. (Eds.), Proceedings of the Eighth International Conference on Equine Infectious Diseases VIII. R&W Publications, Newmarket, Suffolk, UK, pp. 64-70.