Association between BRCA1 Mutations and Ratio of Female to Male Births in Offspring of Families with, Breast Cancer, Ovarian Cancer, or Both

JAMA

Volumn 290, Issue 7, 2003, Pages 929-931

  De La Hoya, Miguel ^a   Fernández, Juan M ^a   Tosar, Alicia ^a   Godino, Javier ^a   De Abajo, Ana Sánchez ^a   Vidart, Jose A ^a   Pérez Segura, Pedro ^a   Díaz Rubio, Eduardo ^a   Caldés, Trinidad ^a  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIRTH; BREAST CANCER; FAMILY; FEMALE; GENE MUTATION; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONCOGENE; OVARY CANCER; PEDIGREE; PRIORITY JOURNAL; SEX RATIO; SPAIN; X CHROMOSOME INACTIVATION; BREAST TUMOR; GENETICS; MUTATION; OVARY TUMOR; PHENOTYPE; TUMOR SUPPRESSOR GENE;

BREAST NEOPLASMS; FEMALE; GENES, BRCA1; GENES, BRCA2; GERM-LINE MUTATION; HUMANS; MALE; OVARIAN NEOPLASMS; PEDIGREE; PHENOTYPE; SEX RATIO;

EID: 0043198132     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.290.7.929     Document Type: Article

References (5)

1. Venkitaraman AR. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell. 2002;108:171-182.
2. de la Hoya M, Osorio A, Godino J, et al. Association between BRCA1 and BRCA2 mutations and cancer phenotype in Spanish breast/ovarian cancer families: implications for genetic testing. Int J Cancer. 2002;97:466-471.
3. Lee JT. Homozygous TSIX mutant mice reveal a sex-ratio distortion and revert to random X-inactivation. Nat Genet. 2002;32:195-200.
4. Buller RE, Sood AK, Lallas T, et al. Association between nonrandom X-chromosome inactivation and BRCA1 mutation in germline DNA of patients with ovarian cancer. J Natl Cancer Inst. 1999;91:339-346.
5. Ganesan S, Silver DP, Greenberg RA, et al. BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell. 2002;111:393-405.