Pharmacology of airway goblet cell mucin release

Journal of Pharmacological Sciences

Volumn 92, Issue 4, 2003, Pages 301-307

  Kim, Kwang Chul ^a   Hisatsune, Akinori ^a,b   Kim, Do Jin ^a   Miyata, Takeshi ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Mucus; Regulation; Secretion

Indexed keywords

GENE PRODUCT; MUCIN; OLIGOSACCHARIDE;

AIRWAY; BRONCHUS MUCUS; CELL CULTURE; CELL HYPERPLASIA; GOBLET CELL; HUMAN; LUNG DISEASE; MACROMOLECULE; MEDICAL INFORMATION; MEDICAL RESEARCH; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS INHIBITION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVIEW; TISSUE SPECIFICITY;

EID: 0043197045     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.92.301     Document Type: Review

References (51)

1. Lamblin G, Aubert JP, Perini JM, et al. Human respiratory mucins. Eur Respir J. 1992;5:247-256.
2. Kim KC, McCraken K, Lee BC, et al. Airway goblet cell mucin: Its structure and regulation of secretion. Eur Respir J. 1997;11:2644-2649.
3. Rose M, Gendler S. Airway mucin genes and gene products. In: Rogers DF, Lethem MI, editors. Airway Mucus. Basic Mechanisms and Clinical Prospectives. Basel: Birkhauser Verlag; 1997. p. 41-66.
4. Moniaux N, Escande F, Porchet N, Aubert JP, Batra SK. Structural organization and classification of the human mucin genes. Front Biosci. 2001;6:D1192-D1206.
5. Rose MC, Nickola TJ, Voynow JA. Airway mucus obstruction: Mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia. Am J Respir Cell Mol Biol. 2001;25:533-537.
6. Nadel JA. Role of epidermal growth factor receptor activation in regulating mucin synthesis. Respir Res. 2001;2:85-89.
7. Jeffery PK. Structure and function of mucus-secreting cells of cat and goose airway epithelium. In: Respiratory Tract Mucus. Ciba Foundation Symposium Series 54. New York: Elsevier Excerpta Medica North-Holland; 1978. p. 5-23.
8. Chen Y, Zhao YH, Di YP, Wu R. Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5′-flanking region. Am J Respir Cell Mol Biol. 2001;25:542-553.
9. Groneberg DA, Eynott PR, Oates T, et al. Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Respir Med. 2002;96:81-86.
10. Li JD, Feng W, Gallup M, et al. Activation of NF-kappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells. Proc Natl Acad Sci USA. 1998;95:5718-5723.
11. Kim KC, Wasano K, Niles RM, Schuster JE, Stone PJ, Brody JS. Human neutrophil elastase releases cell surface mucins from primary cultures of hamster tracheal epithelial cells. Proc Natl Acad Sci USA. 1987;84:9304-9308.
12. Paul E, Lee DI, Hyun SW, Gendler SJ, Kim KC. Identification and characterization of high molecular-mass mucin-like glycoproteins in the plasma membrane of airway epithelial cells. Am J Respir Cell Mol Biol. 1998;19:681-690.
13. Boshell M, Lalani E-N, Pemberton L, Burchell J, Gendler S, Taylor-Papadimitriou J. The product of the human MUC1 gene when secreted by mouse cells transfected with the full-length cDNA lacks the cytoplasmic tail. Biochem Biophys Res Commun. 1992;185:1-8.
14. Thathiah A, Blobel CP, Carson DD. Tumor necrosis factor-a converting enzyme (TACE)/ADAM 17 mediates MUC1 shedding. J Biol Chem. 2003;278:3386-3394.
15. Williams CJ, Wreschner DH, Tanaka A, Tsarfaty I, Keydar I, Dion AS. Multiple protein forms of the human mammary tumor-associated epithelial membrane antigen (EMA) are generated by alternative splicing and induced by hormonal stimulation. Biochem Biophys Res Commun. 1990;170:1331-1338.
16. Komatsu M, Arango ME, Carraway KL. Synthesis and secretion of Muc4/sialomucin complex: Implication of intracellular proteolysis. Biochem J. 2002;368:41-48.
17. Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: Central mediator of allergic asthma. Science. 1999;282:2258-2261.
18. Louahed J, Toda M, Jen J, et al. Interleukin-9 upregulates mucus expression in the airways. Am J Respir Cell Mol Biol. 2000;22:649-656.
19. Nakanishi A, Morita S, Iwashita H, et al. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci USA. 2001;98:5175-5180.
20. Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem. 2003;278:17036-17043.
21. Spicer SS, Schulte BA, Thomopoulos GN. Histochemical properties of the respiratory tract epithelium in different species. Am Rev Respir Dis. 1983;128:S20-S26.
22. Gum JR. Mucin genes and the proteins they encode: Structure, diversity, and regulation. Am J Respir Cell Mol Biol. 1992;7:557-564.
23. Kim KC. Mucin-like glycoproteins secreted from cultured hamster tracheal surface epithelial cells: Their hydrophobic nature and amino acid composition. Exp Lung Res. 1991;17:65-76.
24. Jacquot J, Hayem A, Galabert C. Functions of proteins and lipids in airway secretion. Eur Respir J. 1992;5:343-358.
25. Kent PW. Chemical aspects of tracheal glycoproteins. In: Respiratory Tract Mucus. Ciba Foundation Symposium Series 54. New York: Elsevier Excerpta Medica North-Holland; 1978. p. 155-170.
26. Boat TF, Kleinerman JI, Carlson DM, Maloney WH, Mathews LW. Human respiratory tract secretions. 1. Mucous glycoproteins secreted by cultured nasal polyp epithelium from subjects with allergic rhinitis and with cystic fibrosis. Am Rev Respir Dis. 1974;110:428-441.
27. Cheng PW, Sherman JM, Boat TF, Bruce M. Quantitation of radiolabeled mucous glycoproteins secreted by tracheal explants. Anal Biochem. 1981;1:301-306.
28. Kim KC. Possible requirement of collagen gel substratum for production of mucin-like glycoproteins by primary rabbit tracheal epithelial cells in culture. In Vitro. 1985;21:617-621.
29. Kim KC, Brody JS. Use of primary cell culture to study regulation of airway surface epithelial mucus secretion. In: Chanter EN, Ratcliffe NA, editors. Mucus and Related Topics. Cambridge: The Company of Biologist Limited; 1989. p. 231-239.
30. Kim KC, Rearick JI, Nettesheim P, Jetten AM. Biochemical characterization of mucin secreted by hamster tracheal epithelial cells in primary culture. J Biol Chem. 1985;260:4021-4027.
31. Wu R, Zhao YH, Chang MMJ. Growth and differentiation of conducting airway epithelial cells in culture. Eur Respir J. 1997;10:2398-2403.
32. Adler KB, Schwarz JE, Whitcutt JM, Wu R. A new chamber system for maintaining differentiated guinea pig respiratory epithelial cells between air and liquid phases. Biotechniques. 1987;5:462-467.
33. Jackson AD. Airway goblet-cell mucus secretion. Trends Pharmacol Sci. 2001;22:39-45.
34. Kim KC, Lee BC. P2 purinoceptor regulation of mucin release by airway goblet cells in primary culture. Br J Pharmacol. 1991;103:1053-1056.
35. Kim KC, Zheng OX, Van Seuningen I. Involvement of a signal transduction mechanism in ATP-induced mucin release from cultured airway goblet cells. Am J Respir Cell Mol Biol. 1993;8:121-125.
36. Ko KH, Jo MJ, McCraken K, Kim KC. ATP-induced mucin release involves, in part, activation of protein kinase C. Am J Respir Cell Mol Biol. 1997;16:194-198.
37. 2+ activation of mucin secretion in airway goblet cells. Am J Physiol. 1997;273:L201-L210.
38. Kim KC, Zheng QX, Brody JS. Effect of floating a gel matrix on mucin release in cultured airway epithelial cells. J Cell Physiol. 1993;156:480-486.
39. Homolya L, Steinberg TH, Boucher RC. Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia. J Cell Biol. 2000;150:1349-1359.
40. 2u purinoceptor. Eur Respir J. 1996;9:542-548.
41. Chen Y, Zhao YH, Wu R. Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates. Am J Respir Cell Mol Biol. 2001;25:409-417.
42. Adler KB, Fischer BM, Li H, Choe NH, Wright DT. Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase. Am J Respir Cell Mol Biol. 1995;13:526-530.
43. Wright DT, Fischer BM, Li C, Rochelle LG, Akley NJ, Adler KB. Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism. Am J Physiol. 1996;271:L854-L861.
44. Kai H, Yoshitake K, Hisatsune A, et al. Dexamethasone suppresses mucus production and MUC-2 and MUC-5AC gene expression by NCI-H292 cells. Am J Physiol. 1996;271:L484-L488.
45. Kim KC, Gleich GJ, Lee MK. Two eosinophil granule proteins, eosinophil peroxidase and major basic protein, inhibit mucin release from airway goblet cells. Inflamm Res. 1999;48:314-317.
46. Ko KH, Lee CJ, Shin CY, Kim KC. Inhibition of mucin release from airway goblet cells by polycationic peptides. Am J Physiol. 1999;277:L811-L815.
47. Wagner JG, Harkema JR, Levitt RC, Holroyd KJ. Attenuation of endotoxin-induced mucus hypersecretion and airway inflammation by MSI-2216, a calcium-activated chloride channel inhibitor. Am J Respir Cell Mol Biol. 2003;28:A466.
48. Li Y, Martin LD, Spizz G, Adler KB. MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. J Biol Chem. 2001;276:40982-40990.
49. Kishioka C, Okamoto K, Hassett DJ, De Mello D, Rubin BK. Pseudomonas aeruginosa alginate is a potent secretagogue in the isolated ferret trachea. Pediatr Pulmonol. 1999;27:174-179.
50. Kim KC. Regulation of airway goblet cell mucin secretion. In: Takishima T, Shimura S, editors. Lung Biology in Health and Disease, Vol. 72. Airway Secretion: Physiological Bases for the Control of Mucus Hypersecretion. New York: Marcel Dekker; 1994. p. 433-449.
51. Miyata T, Kai H, Isohama Y, Takahama K. Current opinion of muco-active drug research: Strategies and problems. Eur Respir J. 1998;11:480-491.