Recombinant prostate specific antigen inhibits angiogenesis in vitro and in vivo

Prostate

Volumn 56, Issue 3, 2003, Pages 212-219

  Fortier, A H ^a   Holaday, J W ^a   Liang, H ^a   Dey, C ^a   Grella, D K ^a   Holland Linn, J ^a   Vu, H ^a   Plum, S M ^a   Nelson, B J ^a  

^a ENTREMED INC   (United States)

Author keywords

Angiogenesis inhibitor; Kallikrein; Prostate; Prostate specific antigen

Indexed keywords

ANGIOGENESIS INHIBITOR; FIBROBLAST GROWTH FACTOR 2; PROSTATE SPECIFIC ANTIGEN; PROTEINASE; RECOMBINANT PROSTATE SPECIFIC ANTIGEN; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL MIGRATION; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; MALE; MOLECULAR CLONING; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PURIFICATION;

ANGIOGENESIS INHIBITORS; ENDOTHELIAL GROWTH FACTORS; HUMANS; HYDROLYSIS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOKINES; MALE; NEOVASCULARIZATION, PATHOLOGIC; PICHIA; PLASMIDS; POLYMERASE CHAIN REACTION; PROSTATE-SPECIFIC ANTIGEN; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0043172551     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/pros.10256     Document Type: Article

References (27)

1. Fortier AH, Nelson BJ, Grella DK, Holaday JW. Antiangiogenic activity of prostate-specific antigen. JNCI 1999;91:1635-1640.
2. Diamandis EP, Yousef GM, Luo LY, Magklara X, Obiezu CV. The new human kallikrein gene family: Implications in carcinogenesis. Trends Endocrin Metab 2000;11:54-60.
3. Black MH, Diamandid EP. The diagnostic and prognostic utility of prostate-specific antigen for diseases of the breast. Breast Cancer Treat 2000;59:1-14.
4. Hantmann S, Huland E, Grupp C, Haese A, Huland H. Supersensitive prostate-specific antigen (PSA) in serum of women with benign breast disease or breast cancer. Anticancer Res 2000; 20:2151-2154.
5. Diamandis EP. Prostate-specific antigen: A cancer fighter and a valuable messenger? [Review] Clin Chem 2000;46:896-900.
6. Yu H, Levesque MA, Clark GM, Diamandis EP. Prognostic value of prostate-specific antigen for women with breast cancer: A large United States cohort study. Clin Cancer Res 1998;4:1489-1497.
7. Yu H, Giai M, Diamandis EP, Katsaros D, Sutherland DJA, Levesque MA, Roagna R, Ponzone R, Sismondi P. Prostate-specific antigen is a new favorable prognostic indicator for women with breast cancer. Cancer Res 1995;55:2104-2110.
8. Papadopoulos I, Sivridis E, Giatromanolaki A, Koukourakis MI. Tumor angiogenesis is associated with MUC1 overexpression and loss of prostate-specific antigen expression in prostate cancer. Clin Cancer Res 2001;7:1533-1538.
9. Heidtmann H-H, Nettelbeck DM, Mingels A, Jäger R, Welker H-G, Kontermann RE. Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen. Br J Cancer 1999; 81:1269-1273.
10. Kurkela R, Herrala A, Henttu P, Nai H, Vihko P. Expression of active, secreted human prostate-specific antigen by recombinant baculovirus-infected insect cells on a pilot-scale. Biotechnology 1995;11:1230-1234.
11. Riegman PH, Klaassen P, van der Korput JA, Romijn JC, Trapman J. Molecular cloning and characterization of novel prostate antigen cDNA's. Biochem Biophys Res Commun 1988; 155:181-188.
12. Wang MC, Valenzuela LA, Murphy GP, Chu TM. Purification of a human prostate specific antigen. Invest Urol 1979;17:159-163.
13. Belanger A, van Halbeek H, Graves HCB, Grandbois K, Stamey TA, Huang L, Poppe I, Labrie F. Molecular mass and carbohydrate structure of prostate specific antigen: Studies for establishment of an international PSA standard. Prostate 1995;27: 187-197.
14. Habeck LL, Belagaje RM, Becker GW, Hale JE, Churgay LM, Ulmer M, Yang X-Y, Shackelford KA, Richardson JM, Johnson MG, Mendelsohn LG. Expression, purification, and characterization of active recombinant prostate-specific antigen in Pichia pastoris (yeast). The Prostate 2001;46:298-306.
15. Freer ST, Kraut J, Robertus JD, Wright HT, Xuong NH. Chymotrypsinogen: 2.5-A crystal structure, comparison with a-chymotrypsin, and implications for zymogen activation. Biochemistry 1970;9:1997-2003.
16. Watt KWK, Lee PJ, Timkulu T, Chan WP, Loor R. Human prostate-specific antigen: Structural and functional similarity with serine proteases. PNAS 1986;83:3166-3172.
17. Fortier AH, Grella DK, Nelson BJ, Holaday JW. Response Re: Antiangiogenic activity of Prostate-Specific antigen. JNCI 2000; 92:345.
18. Rittenhouse HG, Finlay JA, Mikolajczyk SD, Partin AW. Human kallikrein 2 (hK2) and prostate-specific antigen (PSA): Two closely related, but distinct, kallikreins in the prostate. Crit Revs Clin Lab Sci 1998;35:275-368.
19. Sauter ER, Daly M, Linahan K, Ehya H, Engstrom PF, Bonney G, Ross EA, Yu H, Diamandis E. Prostate specific antigen levels in nipple aspirate fluid correlate with breast cancer risk. Cancer Epidemiol Biomarkers Prevent 1996;5:967-970.
20. Diamandis EP, Yu H. New biological functions of prostate specific antigen? J Clin Endocrinol Metab 1995;80:1515-1517.
21. Magklara A, Scorilas A, Stephan C, Kristiansen GO, Hauptmann S, Jung K, Diamandis EP. Decreased concentrations of prostate-specific antigen and human glandular kallikrein 2 in malignant versus nonmalignant prostatic tissue. Urology 2000;56:527-532.
22. Sim BKL, McDonald NJ, Gubish ER. Angiostatin and Endostatin: Endogenous inhibitors of tumor growth. Cancer Metastasis Rev 2000;19:181-190.
23. Torriglia A, Perani P, Brossas JY, Altairac S, Zeggai S, Martin E, Treton J, Courtois Y, Counis MF. A caspase-independent cell clearance program. The LEI/L-DNase II Pathway. Ann NY Acad Sci 2000;926:192-203.
24. Fortier AH, Holaday JW, Liang H, Dey C, Grella DK, Izrael-Tomasevic A, Vu H, Plum SM, Nelson BJ. Prostate specific antigen, an anti-angiogenic protein induces apoptosis in endothelial cells. Proc Am Assoc Cancer Res 2001;42:580.
25. Cohen P, Graves HCB, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG. Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 profease found in seminal plasma. J. Clin Endocrinol. Metab. 1992;75:1046-1053.
26. Sutkowski DM, Goode RL, Baniel J, Teater C, Cohen P, McNulty AM, Hsiung HM, Becker GW, Neubauer BL. Growth regulation of prostatic stromal cells by prostate-specific antigen. JNCI 1999; 91:1663-1669.
27. Robert M, Gibbs BF, Jacobson E, Gagnon C. Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor/ semenogelin I. Biochemistry 1997;36:3811-3819.