Measuring the mechanical stress induced by an expanding multicellular tumor system: A case study

Experimental Cell Research

Volumn 289, Issue 1, 2003, Pages 58-66

  Gordon, V D ^a,b   Valentine, M T ^a,b   Gardel, M L ^a,b   Andor Ardo D ^a   Dennison, S ^b   Bogdanov, A A ^c   Weitz, D A ^a,b   Deisboeck, T S ^a,c,d  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Brain tumor; Growth dynamics; In vitro assay; Invasion; Matrigel; Microrheology; Multicellular tumor spheroid; Particle tracking; Strain; Stress; Traction

Indexed keywords

MATRIGEL;

ARTICLE; BRAIN TUMOR; CELL INVASION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN CELL; MECHANICAL PROBE; MECHANICAL STRESS; MICROENVIRONMENT; MULTICELLULAR SPHEROID; PRIORITY JOURNAL; THREE DIMENSIONAL IMAGING; TUMOR GROWTH; TUMOR SPHEROID;

EID: 0043164760     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4827(03)00256-8     Document Type: Article

References (36)

1. 2002-2003, CBTRUS, Central Brain Tumor Registry of the United States, Statistical Report, 1995-1999 (years data collected).
2. Helmlinger G., Netti P.A., Lichtenbeld H.C., Melder R.J., Jain R.K. Solid stress inhibits the growth of multicellular tumor spheroids. Nat. Biotechnol. 15:1997;778-783.
3. Delvoye P., Wiliquet P., Leveque J.-L., Nusgens B.V., Lapiere C.M. Measurement of mechanical forces generated by skin fibroblasts embedded in a three-dimensional collagen gel. J. Invest. Dermatol. 97:1991;898-902.
4. Harris A.K., Wild P., Stopak D. Silicon rubber substrata a new wrinkle in the study of cell locomotion . Science. 208:1980;177-179.
5. Harris A.K., Stopak D., Wild P. Fibroblast traction as a mechanism for collagen morphogenesis. Nature. 290:1981;249-251.
6. Dembo M., Wang Y.-L. Stresses at the cell-to-substrate interface during locomotion of fibroblasts. Biophys. J. 76:1999;2307-2316.
7. Jenkins G., Redwood K.L., Meadows L., Green M.R. Effect of gel re-organization and tensional forces on α2β1integrin levels in dermal fibroblasts. Eur. J. Biochem. 263:1999;93-103.
8. Vernon R.B., Angello J.C., Iruela-Arispe M.L., Lane T.F., Sage E.H. Reorganization of basement membrane matrices by cellular traction promotes the formation of cellular networks in vitro. Lab. Invest. 66:1992;536-547.
9. Guido S., Tranquillo R.T. A methodology for the systematic and quantitative study of cell contact guidance in oriented collagen gels correlation of fibroblast orientation and gel birefringence . J. Cell Sci. 105:1993;317-331.
10. Klein C.E., Dressel D., Steinmayer T., Mauch C., Eckes B., Krieg T., Bankert R.B., Weber L. Integrin α2β1 is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrils. J. Cell Biol. 115:1991;1427-1436.
11. Apodaca G., Rutka J.T., Bouhana K., Berens M.E., Giblin J.R., Rosenblum M.L., McKerrow J.H., Banda M.J. Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells. Cancer Res. 50:1990;2322-2329.
12. Nakano A., Tani E., Miyazaki K., Yamamoto Y., Furuyama J.I. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas. J. Neurosurg. 83:1995;298-307.
13. Uhm J.H., Dooley N.P., Villemure J.G., Yong V.W. Glioma invasion in vitro regulation by matrix metalloprotease-2 and protein kinase C . Clin. Exp. Metastasis. 14:1996;421-433.
14. Chintala S.K., Tonn J.C., Rao J.S. Matrix metalloproteinases and their biological function in human gliomas. Int. J. Dev. Neurosciences. 17:1999;495-502.
15. Vernon R.B., Sage E.H. Contraction of fibrillar type I collagen by endothelial cells a study in vitro . J. Cell Biochem. 60:1996;185-197.
16. Sutherland R.M. Cell and environment interactions in tumor microregions the multicell spheroid model . Science. 240:1988;177-184.
17. Nishikawa R., Ji X.D., Harmon R.C., Lazar C.S., Gill G.N., Cavenee W.K., Huang H.J. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Cancer Res. 91:1994;7727-7731.
18. Deisboeck T.S., Berens M.E., Kansal A.R., Torquato S., Stemmer-Rachamimov A.O., Chiocca E.A. Pattern of self-organization in tumour systems complex growth dynamics in a novel brain tumour spheroid model . Cell Proliferation. 34:2001;115-134.
19. Harris J.M., Zalipsky S. Poly(ethylene glycol) Chemistry and Biological Applications . 1997;American Chemical Society, Washington, DC.
20. M.T. Valentine, Z. Perlman, M.L. Gardel, J. Shin, P.T. Matsudaira, L. Mahadevan, T. Mitchison, D.A. Weitz, Effect of surface chemistry on microrheology experiments: comparison of BSA-blocks, PEG-coated, and carboxylated beads, in preparation.
21. Crocker J.C., Grier D.G. Methods of digital video microscopy for colloidal studies. J. Colloid Interface Sci. 179:1996;298-310.
22. Mason T.G., Weitz D.A. Optical measurements of frequency-dependent linear viscoelastic moduli of complex fluids. Phys. Rev. Lett. 74:1995;1250-1253.
23. Valentine M.T., Kaplan P.D., Thota D., Crocker J.C., Gisler T., Prud'homme R.K., Beck M., Weitz D.A. Investigating the microenvironments of inhomogeneous soft materials with multiple particle tracking. Phys. Rev. E. 64:2001;061506.
24. Kleinman H.K., McGarvey M.L., Hassell J.R., Star V.L., Cannon F.B., Laurie G.W., Martin G.R. Basement membrane complexes with biological activity. Biochemistry. 25:1986;312-318.
25. Timoshenko S.P., Goodier J.N. Theory of Elasticity. 3rd ed:1987;McGraw-Hill, New York.
26. Landau L.D., Lifshitz E.M. Theory of Elasticity. 3rd ed:1986;Pergamon Books Ltd, New York.
27. Wrobel L.K., Fray T.R., Molloy J.E., Adams J.J., Armitage M.P., Sparrow J.C. Contractility of single human dermal myofibroblasts and fibroblasts. Cell Motil. Cytoskeleton. 52:2002;82-90.
28. Galbraith C.G., Sheetz M.P. A micromachined device provides a new bend on fibroblast traction forces. Proc. Natl. Acad. Sci. USA. 94:1997;9114-9118.
29. Balaban N.Q., Schwarz U.S., Riveline D., Goichberg P., Tzur G., Sabanay I., Mahalu D., Safran S., Bershadsky A., Addadi L., Geiger B. Force and focal adhesion assembly a close relationship studied using elastic micropatterned substrates . Nat. Cell Biol. 3:2001;466-472.
30. Kansal A.R., Torquato S., Harsh G.R. IV, Chiocca E.A., Deisboeck T.S. Simulated brain tumor growth dynamics using a three-dimensional cellular automaton. J. Theor. Biol. 203:2000;367-382.
31. Silbergeld D.L., Chicoine M.R. Isolation and characterization of human malignant glioma cells from histologically normal brain. J. Neurosurg. 86:1997;525-531.
32. S. Zhang, D.H. Laidlaw, M.E. Bastin, S. Sinha, T.S. Deisboeck. Computational visualization and analysis of structural heterogeneity in a diffusion tensor MRI-data set from a brain tumor patient, submitted.
33. Paulus W., Tonn J.C. Basement membrane invasion of glioma cells is mediated by integrin receptors. J. Neurosurg. 80:1994;515-519.
34. Davis G.E., Camarillo C.W. Regulation of endothelial cell morphogenesis by integrins, mechanical forces, and matrix guidance pathways. Exp. Cell Res. 216:1995;113-123.
35. Tranquillo R.T. Self-organization of tissue equivalents the nature and role of contact guidance . Biochem. Soc. Symp. 65:1999;27-42.
36. Vaithilingam I.S., Stroude E.C., McDonald W., Del Maestro R.F. General protease and collagenase (IV) activity in C6 astrocytoma cells, C6 spheroids and implanted C6 spheroids. J. Neuro-Onc. 10:1991;203-212.