Combination chemotherapy with JTE-522, a novel selective cyclooxygenase-2 inhibitor, and cisplatin against gastric cancer cell lines in vitro and in vivo

In Vivo

Volumn 17, Issue 3, 2003, Pages 229-233

  Sugiura, Tsudoi ^a   Saikawa, Yoshiro ^a   Kubota, Tetsuro ^a   Suganuma, Kazuhiro ^a   Otani, Yoshihide ^a   Watanabe, Masahiko ^a   Kumai, Koichiro ^a   Kitajima, Masaki ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Cisplatin; Cyclooxygenase 2; Gastric cancer cell lines; JTE 522; NSAIDs

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTINEOPLASTIC AGENT; CISPLATIN; CYCLOOXYGENASE 2 INHIBITOR; TILMACOXIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASSAY; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER TRANSPLANTATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUDE MOUSE; STOMACH CANCER;

EID: 0043124371     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Carter SK: Cancer treatment today and its impact on drug development with special emphasis on the phase II clinical trial. J Natl Cancer Inst 57: 253-344, 1976.
2. Sakata Y, Ohtsu A, Horikoshi N et al: Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1 M tegafur-0.4M gimestat-1M otastat potassium) in advanced gastric cancer patients. Eur J Cancer 34: 1715-1720, 1998.
3. Simon LS: Biologic effects of nonsteroidal anti-inflammatory drugs. Curr Opin Rheumatol 9: 178-182, 1997.
4. Wakitani K, Tazaki H, Matsushita M et al: JTE-522 selectively inhibits cyclooxygenase-2 derived prostaglandin production in inflammatory tissues. Inflamm Res 49(3): 117-122, 2002.
5. Thun MJ, Namboodiri MM, Calle EE et al: Aspirin use and reduced risk of fatal colon cancer. Cancer Res 53: 1322-1327, 1993.
6. Giovannucci E, Egan KM, Hunter DJ et al: Aspirin and the risk of colorectal cancer in woman. N Engl J Med 333: 609-614, 1995.
7. Sheng H, Shao J, Kirkland SC et al: Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest 99: 2254-2259, 1997.
8. Hara A, Yoshimi N, Niwa M et al: Apoptosis induced by NS-398, a selective cyclooxygenase-2 inhibitor, in human colorectal cancer cell lines. Jpn J Cancer Res 58: 362-366, 1998.
9. Wakitani K, Nanayama T, Masaki M et al: Profile of JTE-522 as a human cyclooxygenase-2 inhibitor. Jpn J Pharmacol 78(3): 365-371, 1998.
10. Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.
11. Geran RI, Greenberg NH, MacDonald MM et al: Protocols for screening chemical agents and natural products and other biological systems. 3rd ed. Cancer Chemother Rep (Part 3) 3: 1-103, 1972.
12. Giardiello FM, Hamilton SR, Krush AJ et al: Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med 328: 1313-1316, 1993.
13. Oshima M, Dinchuk LE, Kargman SL et al: Suppression of intestinal polyposis in Apc-716 knockout mice by inhibition of cyclooxygenase-2 (COX-2). Cell 87: 803-809, 1996.
14. Elder DJE, Hague A, Hicks DJ et al: Differential growth inhibition by aspirin metabolite salicylate in human colorectal tumor cell lines: Enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma cell lines. Cancer Res 56: 2273-2276, 1996.
15. Hida T, Kozaki K, Ito H et al: Significant growth inhibition of human lung cancer cells both in vitro annd in vivo by the combined use of a selective cyclooxygenase-2 inhibitor, JTE-522, and conventional anticancer agents. Clin Cancer Res 8(7): 2443-2447, 2002.
16. Li HL, Chen DD, Li XH et al: JTE-522-induced apoptosis in human gastric adenocarcinoma cell line AGS cells by caspase activation accompanying cytochromme C release, membrane translocation of Bax and loss mitochondrial membrane potential. World J Gastroenterol 8(2): 217-223, 2002.
17. Zhu GH, Wong BCY, Eggo MC et al: Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. Br J Cancer 79: 393-400, 1999.
18. Shiff SJ, Koutsos MI, Qiao L et al: Nonsteroidal anti-inflammatory drugs inhibit the proliferations of colon adenocarcinoma cells: Effects on cell cycle and apoptosis. Exp Cell Res 222: 179-188, 1996.