Long-term expression of fibrogenic cytokines in radiation-induced damage to the internal anal sphincter

Swiss Surgery

Volumn 9, Issue 4, 2003, Pages 193-197

  Gervaz, Pascal ^b   Hennig, R ^c   Buechler, M ^c   Soravia, C ^c   Brigstock, D R ^a   Morel, Ph ^c   Egger, J F ^c   Friess, H ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c NONE

Author keywords

Anal sphincter; Connective tissue growth factor; Fibrosis; Radiation; Transforming growth factor beta1

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

AGED; ANUS SPHINCTER; ANUS SPHINCTER DISORDER; ARTICLE; CASE REPORT; ENDOTHELIUM CELL; FIBROBLAST; FIBROSIS; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MYOFIBROBLAST; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RADIATION INJURY; RECTUM ABDOMINOPERINEAL RESECTION; RECTUM CARCINOMA; SMOOTH MUSCLE;

EID: 0043092455     PISSN: 10239332     EISSN: None     Source Type: Journal    
DOI: 10.1024/1023-9332.9.4.193     Document Type: Article

References (15)

1. Kollmorgen CF, Meagher AP, Wolff BG, Pemberton JH, Martenson JA, Illstrup DM. The long-term effects of adjuvant postoperative chemoradiotherapy for rectal carcinoma on bowel function. Ann Surg 1994; 220:676-682.
2. Dahlberg M, Glimelius B, Graf W, Pahlman L. Preoperative irradiation affects functional results after surgery for rectal cancer. Dis Colon Rectum 1998; 41:543-551.
3. Vordermark D, Sailer M, Flentje M, Thiede A, Kolbl O. Curative-intent radiation therapy in anal carcinoma: quality of life and sphincter function. Radiother Oncol 1999: 52:239-243.
4. Richter KK, Langberg CW, Sung CC, Hauer-Jensen M. Increased transforming growth factor β immunoreactivity is independently associated with chronic injury in both consequential and primary radiation enteropathy. Int J Radiat Oncol Biol Phys 1997; 39:187-195.
5. Wang J, Zheng H, Sung CC, Richter KK, Hauer-Jensen M. Cellular sources of transforming growth factor βisoforms in early and chronic radiation enteropathy. Am J Pathol 1998; 153:1531-1540.
6. Martin M, Lefaix J, Delanian S. TGF-beta 1 and radiation fibrosis: A master switch and a significant therapeutic target? Int J Radiat Oncol Biol Phys 2000; 47:277-290.
7. Rubin P. Johnston CJ, Williams JP, McDonald S, Finkelstein JN. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys 1995; 33:99-109.
8. Bradham DM, lgarashi A, Potter RL, Grotendorst GR. Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate gene product CEF-10. J Cell Biol 1991; 114:1285-1294.
9. Duncan MR, Frazier KS, Abramson S. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP. FASEB J 1999 13:1774-1786.
10. Abou-Shady M, Friess H, Zimmermann A, di Mola FF, Guo XZ, Baer HU, Büchler MW. Connective tissue growth factor in human liver cirrhosis. Liver 2000; 20:296-304.
11. Di Mola FF, Friess H, Martignoni ME, Di Sebastiano P. Zimmermann A, Innocenti P, Graber H, Gold LI, Korc M, Büchler MW. Connective tissue growth factor is a regulator for fibrosis in human chronic pancreatitis. Ann Surg 1999; 230:63-71.
12. Brigstock DR. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev 1999; 20: 189-206.
13. Brenner DJ, Curtis RE, Hall EJ, Ron E. Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery. Cancer 2000; 88:398-406.
14. Gervaz P, Rotholtz N, Pisano M, Kaplan E, Secic M, Coucke P, Pikarsky A, Efron J, Weiss E, Wexner S. Short-term quantitative study of anal sphincter function after chemo-radiation for rectal cancer,. Arch Surg 2001; 136;:192-196.
15. Gervaz P,. Wexner SD, Pemberton JH. Pelvic radiation and anorectal function: introducing the concept of sphincter-preserving radiation therapy. J Am Coll Surg 2002; 195:387-394.