Urinary excretion of salicyluric and salicylic acids by non-vegetarians, vegetarians, and patients taking low dose aspirin

Journal of Clinical Pathology

Volumn 56, Issue 9, 2003, Pages 651-653

  Lawrence, J R ^a   Peter, R ^a   Baxter, G J ^a   Robson, J ^b   Graham, A B ^c   Paterson, J R ^a  

^a DUMFRIES AND GALLOWAY ROYAL INFIRMARY   (United Kingdom)

^b Surgery   (United Kingdom)

^c UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; SALICYLIC ACID; SALICYLURIC ACID;

ARTICLE; DRUG BIOAVAILABILITY; DRUG URINE LEVEL; ELECTROCHEMICAL ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LOW DRUG DOSE; PRIORITY JOURNAL; VEGETARIAN;

ADOLESCENT; ADULT; AGED; ASPIRIN; BIOLOGICAL AVAILABILITY; CYCLOOXYGENASE INHIBITORS; DIET, VEGETARIAN; DRUG ADMINISTRATION SCHEDULE; FEMALE; HIPPURATES; HUMANS; MALE; MIDDLE AGED; SALICYLIC ACIDS; STATISTICS, NONPARAMETRIC;

EID: 0043029134     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.56.9.651     Document Type: Article

References (10)

1. Blacklock CJ, Lawrence JR, Wiles D, et al. Salicylic acid in the serum of patients not taking aspirin. Comparisons of salicylic acid concentrations in the serum of vegetarians, non-vegetarians and patients taking low dose aspirin. J Clin Pathol 2001;54:553-5
2. Davison C. Salicylate metabolism in man. Ann N Y Acad Sci 1971;179:249-68.
3. Needs CJ, Brooks PM. Clinical pharmacokinetics of the salicylates. Clin Pharmacokinet 1985;10:164-77.
4. Baxter GJ, Lawrence JR, Graham AB, et al. Identification and determination of salicylic acid and salicyluric acid in the urine of people not taking salicylate drugs. Ann Clin Biochem 2002;39:50-5.
5. Lim RKS. The salicylates. In: Smith MJH, Smith PK, eds. The salicylates. Interscience Publishers, 1966:181.
6. Janssen PLTMK, Hollman PCH, Reichman E, et al. Urinary salicylate excretion in subjects eating a variety of diets shows that amounts of bioavailable salicylates in foods are low. Am J Clin Nutr 1996;64:743-7.
7. Yudkin JS. Which diabetic patients should be taking aspirin? BMJ 1995;311:641-2
8. Ingster LM, Feinleib M. Could salicylates in food have contributed to the decline in cardiovascular disease mortality? A new hypothesis. Am J Public Health 1997;87:1554-7.
9. Paterson JR, Lawrence JR. Salicylic acid: a link between aspirin, diet and the prevention of colorectal cancer. Q J Med 2001;94:445-8.
10. Dubovska D, Piotrovskij VK, Gajdos M, et al. Phamacokinetics of acetylsalicylic acid and its metabolites at low doses: a compartmental model. Methods Find Exp Clin Pharmacol 1995;17:67-77.