Cyclooxygenase-inhibition enhances the effects of rSP-C surfactant therapy in a rat lavage model of Acute Respiratory Distress Syndrome (ARDS)

Experimental and Toxicologic Pathology

Volumn 55, Issue 1, 2003, Pages 59-68

  Häfner, Dietrich ^a   Ibrahim, Merdol ^b   Wollin, Lutz ^a   Germann, Paul Georg ^b  

^a Dept of Respiratory Pharmacology ^*  (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Acute lung injury; ARDS; Confocal microscopy; Cyclooxygenase inhibitor; Eltenac; Gas exchange; Hyaline membrane formation; Intratracheal therapy; Rat lung lavage model; rSP C surfactant

Indexed keywords

ELTENAC; FIBRINOGEN; LUSUPULTIDE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; RECOMBINANT PROTEIN; SURFACTANT PROTEIN C; UNCLASSIFIED DRUG;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; INFLAMMATORY CELL; INTRAVENOUS ADMINISTRATION; LOW DRUG DOSE; LUNG INFILTRATE; LUNG LAVAGE; MEMBRANE FORMATION; NONHUMAN; OXYGENATION; RAT;

ANIMALIA;

EID: 0043027013     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1078/0940-2993-00295     Document Type: Article

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