A possible primordial peptide cycle

Science

Volumn 301, Issue 5635, 2003, Pages 938-940

  Huber, Claudia ^a   Eisenreich, Wolfgang ^a   Hecht, Stefan ^a   Wächtershäuser, Günter ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CARBON MONOXIDE; NICKEL; UREA;

PEPTIDE FORMATION;

PROTEINS;

ALPHA AMINO ACID; CYCLOPEPTIDE; HYDANTOIN DERIVATIVE; PHENYLALANINE; UREA;

AMINO ACID; PEPTIDE;

AMINO ACID ANALYSIS; ARTICLE; CHEMICAL REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL;

AMINO ACIDS; BIOGENESIS; CARBON DIOXIDE; CARBON MONOXIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIPEPTIDES; EVOLUTION, CHEMICAL; FERROUS COMPOUNDS; HEAT; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MASS SPECTROMETRY; NICKEL; OXIDATION-REDUCTION; PEPTIDES; PHENYLALANINE; PRESSURE; STEREOISOMERISM; UREA; UREASE;

EID: 0043023785     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1086501     Document Type: Article

References (9)

1. C. Huber, G. Wächtershäuser, Science 281, 670 (1998).
2. Materials and methods are available as supporting material on Science Online.
3. H. R. Kricheldorf α-Aminoacid-N-Carboxy Anhydrides and Related Heterocycles: Syntheses, Properties, Peptide Synthesis, Polymerization (Springer Verlag, Berlin, 1987).
4. C. Slydatk et al., Appl. Microbiol. Biotechnol. 51, 293 (1999).
5. G. Wächtershäuser, Microbiol. Rev. 52, 452 (1988).
6. C. Huber, G. Wächtershäuser, Science 276, 245 (1997).
7. J. Taillades et al., Origins Life Evol. Biosph. 28, 61 (1998).
8. E. Jabri et al., Science 268, 998 (1995).
9. This work was funded by Deutsche Forschungsgemeinschaft (WA-1983/1-4). We thank A. Bacher for providing the laboratory facilities for carrying out this work and for continued support, B. Cordes for HPLC-MS, and M. Schulte-Bockholt for laboratory assistance.