Amplification of the androgen receptor may not explain the development of androgen-independent prostate cancer

BJU International

Volumn 88, Issue 6, 2001, Pages 633-637

  Edwards, J ^a   Krishna, N S ^a   Mukherjee, R ^a   Watters, A D ^a   Underwood, M A ^a   Bartlett, J M S ^a  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

Androgen receptor; Fluorescence in situ hybridization; Prostate cancer; X chromosome

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANTIANDROGEN;

ADULT; AGED; ANAMNESIS; ARTICLE; CANCER GROWTH; CANCER RECURRENCE; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE RESISTANCE; DRUG RESPONSE; FLUORESCENCE; FOLLOW UP; GENE AMPLIFICATION; GENE PROBE; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN ANALYSIS; X CHROMOSOME;

AGED; AGED, 80 AND OVER; ANDROGEN ANTAGONISTS; ANTINEOPLASTIC AGENTS, HORMONAL; GENE AMPLIFICATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; PILOT PROJECTS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RETROSPECTIVE STUDIES; X CHROMOSOME;

EID: 0035731528     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410X.2001.02350.x     Document Type: Article

References (17)

1. Combined androgen blockade for advanced prostatic carcinoma
2. Prostate-specific membrane antigen (FOLH1): Recent advances in characterising this putative prostate cancer gene
3. Combined androgen blockade: The gold standard for metastatic prostate cancer
4. Androgen receptor expression in androgen independent prostate cancer is associated with increased expression of androgen regulated genes
5. Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation
6. The androgen receptor in prostate cancer
7. Erratum: The CAG repeat within the androgen receptor gene and its relationship to prostate cancer
8. Assessment of hormone refractory prostate cancer
9. In vivo amplification of the androgen receptor gene and progression of human prostate cancer
10. Androgen receptor gene amplification: A possible molecular mechanism for androgen deprivation therapy failure in prostate cancer
11. Fluorescence in situ hybridization evaluation of c-myc and androgen receptor gene amplification and chromosomal anomalies in prostate cancer in Japanese patients
12. Survey of gene amplifications during prostate cancer progression by high throughput fluorescence in situ hybridization on tissue microarrays
13. Is chromosome 9 loss a marker of disease recurrence in transitional cell carcinoma of the urinary bladder?
14. CREB binding protein is a co-activator for the androgen receptor and mediates cross-talk with AP-1
15. Androgen independent induction of prostate specific antigen gene expression via cross talk between the androgen receptor and protein kinase A signal transduction pathways
16. Prostate cancer; molecular biology of early progression to androgen independence
17. Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP