An oestrogen-producing seminoma responsible for gynaecomastia

Hormone and Metabolic Research

Volumn 35, Issue 5, 2003, Pages 324-329

  Duparc, C ^a   Boissiere Veverk, G ^a   Lefebvre, H ^a   Laquerriere, A ^a   Vuillermet, P ^a   Landreat, A ^a   Ivell, R ^b   DeRoux, N ^c   Kuhn, J M ^a  

^a ROUEN UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY OF HAMBURG   (Germany)

^c BICÊTRE HOSPITAL   (France)

Author keywords

Aromatase; Gynaecomastia; Hybrid Tumour; Leydig Cell; Oestradiol; Seminoma

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN RECEPTOR; ESTRADIOL; ESTROGEN; LUTEINIZING HORMONE RECEPTOR; TESTOSTERONE;

ADULT; ARTICLE; CASE REPORT; ECTOPIC HORMONE PRODUCTION; ESTRADIOL BLOOD LEVEL; ESTROGEN RELEASE; ESTROGEN SYNTHESIS; GONADOTROPIN BLOOD LEVEL; GYNECOMASTIA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEYDIG CELL; MALE; PRIORITY JOURNAL; SEMINOMA; TESTOSTERONE BLOOD LEVEL;

ADULT; CHORIONIC GONADOTROPIN; ESTRADIOL; ESTROGENS; GYNECOMASTIA; HORMONES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; ORCHIECTOMY; PERFUSION; RADIOIMMUNOASSAY; SEMINOMA; TESTICULAR NEOPLASMS; TESTOSTERONE;

EID: 0042929868     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-41310     Document Type: Article

References (47)

1. Braunstein GD, Gynecomastia. N Engl J Med 1993; 328: 490-495
2. Javadpour N, McIntire KR, Waldmann TA. Human chorionic gonadotropin and alpha-feto-protein in sera and tumor cells of patients with testicular seminoma. Cancer 1978; 42: 2768-2777
3. Lefebvre H, Laquerriere A, Cleret JM, Kuhn JM. A hCG-secreting testicular seminoma revealed by male infertility: Mechanism of hCG-evoked endocrine disturbances. Andrologia 1993; 25: 283-287
4. Rajpert-De Meyts E, Toppari J, Skakkebaek NE. Testicular tumors with endocrine manifestations In: DeGroot LJ, Jameson JL (ed). Endocrinology Philadelphia: W. B. Saunders, 2001: 2351-2356
5. Aiginger P, Kolbe H, Kühbôck J, Spona J, Geyer G. The endocrinology of testicular germ cell tumours. Acta Endocrinol 1981; 97: 419-426
6. Mumperow E, Hartmann M. Spermatic cord β-human chorionic gonadotropin levels in seminoma and their clinical implications. J Urol 1992; 147: 1041-1043
7. Hainsworth JD, Greco FA. Testicular germ cell neoplasms. Am J Med 1983; 75: 817-832
8. Bercovici JP, Tater D, Khoury S, Charles JF, Floch J, Leroy JP. Leydig cell tumor with gynecomastia: hormonal effects of an estrogen-producing tumor. J Clin Endocrinol Metab 1981; 53: 1291-1296
9. Kuhn JM, Mahoudeau J, Billaud L, Joly J, Rieu M, Gancel A, Archambeau-Mouveroux F, Steg A, Luton JP. Evaluation of diagnosis criteria for Leydig cell tumours in adult men revealed by gynaecomastia. Clin Endocrinol 1987; 26: 407-416
10. Reznik Y, Rieu M, Kuhn JM, Mandard JC, Bottet P, Lemonnier D, Bekka S, Mahoudeau J. Luteinizing hormone regulation by sex steroids in men with germinal and Leydig cell tumours. Clin Endocrinol 1993; 38: 487-493
11. Hendry WF, Garvie WHH, Ah-See AK, Bagliss AP. Ultrasonic detection of occult testicular neoplasms in patients with gynaecomastia. Br J Radiol 1984; 57: 572-573
12. Hass GP, Pittabiga S, Gomella L. Clinically occult Leydig cell tumor presenting with gynecomastia. J Urol 1989; 142: 1325-1327
13. Mahoudeau JA, Luton JP, Bricaire H. Diagnostic d'une tumeur à cellules de Leydig par le test à la gonadotrophine chorionique (hCG). Presse Méd 1980; 9: 536
14. 4 receptor subtype. Neuroscience 1992; 47: 999-1007
15. Thorneycroft IH, Ribeiro WO, Stone SC, Tilison SA. A radioimmunoassay of androstenedione. Steroids 1973; 21: 111-122
16. Furuyama S, Mayes DM, Nugent CA. A radioimmunoassay for plasma testosterone. Steroids 1972; 16: 415-428
17. Wu CH, Lundy LE. Radioimmunassay of plasma estrogens. Steroids 1971; 18: 91-111
18. Weinstein A, Lindner HR, Friedlander A, Bauminger S. Antigenic complexes of steroid hormones formed by coupling to protein through position 7: preparation from 4-3-oxosteroids and characterization of antibodies to testosterone and androstenedione. Steroids 1972; 20: 789-812
19. Lindner HR, Perel E, Friedlander A, Zeitlin A. Specificity of antibodies to ovarian hormones in relation to the steroid hapten to the peptide carrier. Steroids 1972; 19: 357-375
20. Ivell R, Balvers M, Domagalski R, Ungefroren H, Hunt N, Schulze W. Relaxin-like factor: a highly specific and constitutive new marker for Leydig cells in the human testis. Mol Human Reprod 1997; 3: 459-466
21. Meduri G, Charnaux N, Loosefelt H, Jolivet A, Spyratos F, Brailly S, Milgrom E. H, Bunick D, Hess RA. Luteinizing hormone/human chorionic gonadotropin receptors in breast cancer. Cancer Res 1997; 57: 857-864
22. Gabrilove J, Nicolis GL, Mitty HA, Sohval AR. Feminizing interstitial cell tumors of the testis: Personal observations and review of the literature. Cancer 1975; 35: 1184-1202
23. Manivel JC, Jessurun J, Wick MR, Dehner LP. Placental alkaline phosphatase immunoreactivity in testicular germ-cell neoplasms. Am J Surg Pathol 1987; 11: 21-29
24. Niehans GA, Manivel JC, Copland GT, Scheithauer BW, Wick MR. Immunohistochemistry of the germ cell and trophoblastic neoplasms. Cancer 1988; 62: 1113-1123
25. Kommoss F, Oliva E, Bittinger F, KirkPatrick CJ, Amin MB, Bhan AK, Young RH, Scully RE. Inhibin-alpha, CD99, HEA125, PLAP, and chromogranin immunoreactivity in testicular neoplasms and the androgen insensitivity syndrome. Human Pathol 2000; 31: 1055-1061
26. Rieu M, Reznîk Y, Vannetzel JM, Mahoudeau J, Berrod JL, Kuhn JM. Testicular steroidogenesis in adult men with human chorionic gonadotropin-producing tumors. J Clin Endocrinol Metab 1995; 80: 2404-2409
27. Augusto D, Leteurtre E, de la Taille A, Gosselin B, Leroy X. Calretinin: a valuable marker of normal and neoplastic Leydig cells of the testis. Appl Immunohistochem Mol Morphol 2002; 10: 159-162
28. Ulbright TM, Srigley JR, Hatzianastassiou DK, Young RH. Leydig cell tumors of the testis with unusual features: adipose differentiation, calcification with ossification, and spindle-shaped tumor cells. Am J Surg Pathol 2002; 26: 1424-1433
29. Cao QJ, Jones JG, Li M. Expression of calretinin in human ovary, testis, and ovarian sex cord-stromal tumors. Int J Gynecol Pathol 2001; 20: 46-352
30. Busam KJ, Iversen K, Coplan KA, Old LJ, Stockert E, Chen YT, McGregor D, Jungbluth A. Immunoreactivity for A101, an antibody to melan-A (MART-1) in adrenocortical and other steroid tumors. Am J Surg Pathol 1998; 22: 57-63
31. Bergh A, Cajander S. Immunohistochemical localization of inhibin-alpha in the testes of normal men and in men with testicular disorders. Int j Androl. 1990; 13: 463-469
32. Hiroi N, Chrousos GP, Kohn B, Lafferty A, Abu-Asab M, Bonat S, White A, Bornstein SR. Adrenocortical-pituitary hybrid tumor causing Cushing's syndrome. J Clin Endocrinol Metab 2001; 86: 2631-2637
33. Mathison DA, Waterhouse CA. Cushing's syndrome with hypertensive crisis and mixed adrenal cortical adenoma-pheochromocytoma (corticomedullary adenoma). Am J Med 1969 Oct; 47 (4): 635-641
34. Lacroix A, Ndiaye N, Tremblay J, Hamet P. Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome. Endocr Rev 2001; 22: 75-110
35. Brodie A, Insker S. Aromatase in the human testis. J Steroid Biochem Mol Biol 1993; 44: 549-555
36. Insker S, Yue W, Brodie A. Human testicular aromatase: immunocytochemical and biochemical studies. J Clin Endocrinol Metab 1995; 80: 1941-1947
37. Carreau S, Genissel C, Bilinska B, Levallet J. The estrogen sources in the testis and the reproductive tract of the male. Int J Androl 1999; 22: 211-223
38. Janulis L, Bahr JM, Hess RA. Rat testicular germ cells and epididymal sperm contain active P450 aromatase. J Androl 1998; 19: 65-71
39. Bulun SE, Noble LS, Takayama K, Michael MD, Agarwal V, Fisher C, Zhao Y, Hinshelwood MM, Ito Y, Simpson ER. Endocrine disorders associated with inappropriately high aromatase expression. J Steroid Biochem Mol Biol 1997; 61: 133-139
40. Agarwal VR, Takayama K, van WYKJJ, Sasano H, Simpson ER, Bulun SE. Molecular basis of severe gynaecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinome. J Clin Endocrinol Metab 1998; 83: 1797-1800
41. Harada N, Ota H, Yoshimura N, Katsuyama T, Takagi Y. Localized aberrant expression of cytochrome P450 aromatase in primary and metastatic malignant tumors of human liver. J Clinl Endocrinol Metab 1998; 83: 697-702
42. Young J, Bulun SE, Agarwal V, Couzinet B, Mendelson CR, Simpson ER, Schaison G. Aromatase expression in a feminizing adrenocortical tumor. J Clin Endocrinol Metab 1996; 81: 3173-3176
43. O'Marcaigh AS, Ledger GA, Roche PC, Parisi JE, Zimmerman D. Aromatase expression in human germinomas with possible biological effects. J Clin Endocrinol Metab 1995; 80: 3763-3766
44. Coen P, Kulin H, Ballantine T, Zaino R, Frauenhoffer E, Boal D, Insker S, Brodie A, Santen R. An aromatase-producing sex-cord tumor resulting in prepubertal gynecomastia. N Engl J Med 1991; 324: 317-322
45. Young S, Gooneratne S, Straus FH2nd, Zeller WP, Bulun SE, Rosenthal IM. Feminizing Sertoli cell tumors in boys wilh Peutz-Jeghers syndrome. Am J Surg Pathol 1995; 19: 50-58
46. Nakazumi H, Sasano H, Maehara I, Ozaki M, Tezuka F, Orikasa S. Estrogen metabolism and impaired spermatogenesis in germ cell tumors of the testis. J Clin Endocrinol Metab 1996; 81: 1289-1295
47. Nitta H, Bunick D, Hess RA. Germ cells of the mouse testis express P450 aromatase. Endocrinology 1993; 132: 1396-1401