Stem cell therapy for autoimmune disease: Overview of concepts from the Snowbird 2002 tolerance and tissue regeneration meeting

Bone Marrow Transplantation

Volumn 32, Issue , 2003, Pages S3-S5

  Burt, R K ^a   Arnold, R ^b   Emmons, R ^c   Oyama, Y ^a   Marmont, A ^d  

^a NORTHWESTERN UNIVERSITY MEDICAL CENTER   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

Autoimmune disease; Stem cell transplantation; Tissue regeneration

Indexed keywords

CYCLOPHOSPHAMIDE; THYMOCYTE ANTIBODY;

AUTOIMMUNE DISEASE; CLINICAL STUDY; EUROPE; GRAFT VERSUS HOST REACTION; HEALTH CARE ORGANIZATION; HEALTH PRACTITIONER; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; PRIORITY JOURNAL; REVIEW; SYMPOSIUM; TISSUE REGENERATION; WESTERN HEMISPHERE;

AUTOIMMUNE DISEASES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; REGENERATION; TRANSPLANTATION CONDITIONING;

EID: 0042913495     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/sj.bmt.1703935     Document Type: Article

References (21)

1. McSweeney PA, Nash RA, Sullivan KM et al. High-dose immunosuppressive therapy for severe systemic sclerosis: initial outcomes. Blood 2002; 100: 1602-1610.
2. Sondel PM. The graft-versus-leukemia effect. In: Barrett J, Jiang Y-Z (eds). Allogeneic Immunotherapy for Malignant Disease. Delker: New York, 2000, pp 1-12.
3. Appelbaum FR. Hematopoietic stem cell transplantation as immunotherapy. Nat Med 2001; 411: 385-389.
4. Hinterberger W, Hinterberger-Fischer M, Marmont AM. Clinically demonstrable anti-autoimmunity mediated by allogeneic immune cells favourably affects outcomes after stem cell transplantation in human autoimmune diseases. Bone Marrow Transplant 2002; 30: 753-759.
5. Slavin S, Nagler A, Varadi G, Or R. Graft vs autoimmunity following allogeneic non-myeloablative blood stem cell transplantation in a patient with chronic myelogenous leukaemia and severe psoriasis and psoriatic polyarthritis. Exp Hematol 2000; 28: 853-857.
6. Burt RK, Slavin S, Burns WH, Marmont AM. Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure? Blood 2002; 99: 768-784.
7. Bevan MJ, Hogquist KA, Jameson SC. Selecting the T cell receptor repertoire. Science 1994; 264: 796-797.
8. Ashton-Rickardt PG, Tonegawa S. A differential-avidity model for T-cell selection. Immunol Today 1994; 15: 362-366.
9. Sebzda E, Wallace VA, Mayer J et al. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 1994; 263: 1615-1618.
10. Tyndall A, Fassas A, Passweg J et al. Autologous haematopoietic stem cell transplants for autoimmune disease - feasibility and transplant-related mortality. Autoimmune Disease and Lymphoma Working Parties of the European Group for Blood and Marrow Transplantation, the European League Against Rheumatism and the International Stem Cell Project for Autoimmune Disease. Bone Marrow Transplant 1999; 24: 729-34.
11. Moore J, Brooks P, Milliken S et al. A pilot randomized trial comparing CD34-selected versus unmanipulated hemopoietic stem cell transplantation for severe, refractory rheumatoid arthritis. Arthritis Rheum 2002; 46: 2301-2309.
12. Traynor AE, Barr WG, Rosa RM et al. Hematopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patients. Arthritis Rheum 2002; 46: 2917-2923.
13. O'Dell JR, Steigerwald JC, Kennaugh RC et al. Lack of clinical benefit after treatment of systemic sclerosis with total lymphoid irradiation. J Rheumatol 1989; 16: 1050-1054.
14. The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Breast radiotherapy after breast-conserving surgery. Canadian Association of Radiation Oncologists. CMAJ 1998; 158 (Suppl. 3): S35-S42.
15. Kocher AA, Schuster MD, Szabolcs MJ et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001; 7: 430-436.
16. Orlic D, Kajstura J, Chimenti S et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001; 410: 701-705.
17. Petersen BE, Bowen WC, Patrene KD et al. Bone marrow as a potential source of hepatic oval cells. Science 1999; 284: 1168-1170 (Journal Article).
18. Mezey E, Chandross KJ, Harta G et al. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow [Journal Article]. Science. 2000; 290: 1779-1782 (Comment).
19. Korbling M, Katz RL, Khanna A et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med 2002; 346: 738-746.
20. Krause DS, Theise ND, Collector MI et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105: 369-377.
21. Terada N, HamazakiT, Oka M et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002; 416: 542-545.