The cholera toxin B subunit directly costimulates antigen-primed CD4 + T cells ex vivo

Scandinavian Journal of Immunology

Volumn 58, Issue 3, 2003, Pages 342-349

  Wang, M ^a   Bregenholt, S ^a,b   Petersen, J S ^a  

^a NOVO NORDISK A S   (Denmark)

^b Symphogen AS   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN B SUBUNIT; GAMMA INTERFERON; HEMOCYANIN; INTERLEUKIN 2; INTERLEUKIN 4; T LYMPHOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL ISOLATION; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTI-BACTERIAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHOLERA TOXIN; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; HEMOCYANIN; IMMUNOENZYME TECHNIQUES; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MACROLIDES; MICE; MICE, INBRED BALB C; RECOMBINANT PROTEINS;

EID: 0042913243     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2003.01308.x     Document Type: Article

References (31)

1. Spangler BD. Structure and function of cholera toxin and the related Escherichia coli heat-labile endotoxin. Microbiol Rev 1992;56:622.
2. Lindholm L, Holmgren J, Lange S, Lonnroth I. Interaction of cholera toxin and toxin derivatives with lymphocytes. II. Modulating effects of cholera toxin on in vivo humoral and cellular immune reponses. Int Arch Allergy Appl Immunol 1976;50:555.
3. Clarke CJ, Wilson AD, Williams NA, Stokes CR. Mucosal rpiming of T-lymphocyte responses to fed protein antigens using cholera toxin as an adjuvant. Immunology 1991;72:323.
4. Hornquist E, Lycke N. Cholera toxin adjuvant greatly promotes antigen priming of T-cells. Eur J Immunol 1993;23:2136.
5. Holmgren J, Lindholm L, Lonnroth I. Interaction of cholera toxin and toxin derivatives with lymphocytes. I. Binding properties and interference with lectin-induced cellular stimulation. J Exp Med 1974;139:801.
6. Holmgren J, Lycke N, Czerkinsky C. Cholera toxin and cholera toxin B-subunit as oral-mucosal adjuvant and antigen vector system. Vaccine 1993;11:1179.
7. Sun JB, Holmgren J, Czerkinsky C. Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc Natl Acad Sci USA 1994;91:10795.
8. Sun JB, Rask C, Olsson T, Holmgren J, Czerkinsky C. Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjuagted to cholera toxin B subunit. Proc Natl Acad Sci USA 1996;93:7196.
9. Bergerot I, Ploix C, Petersen J et al. A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes. Proc Natl Acad Sci USA 1997;94:4610.
10. Rask C, Holmgren J, Frederiksson M et al. Prolonged oral treatment with low doses of allergen conjugated to cholera toxin B subunit suppresses immunoglobulin E antibody responses in sensitized mice. Clin Exp Allergy 2000;30:1024.
11. Wu HY, Russel MW. Induction of mucosal and systemic immune responses by intranasal immunization using recombinant cholera toxin B subunit as an adjuvant. Vaccine 1998;16:286.
12. Tochikubo K, Isaka M, Yasuda Y et al. Recombinant cholera toxin B subunit act as an adjuvant for the mucosa and systemic response of mice to mucosally co-administered bovime serum albumin. Vaccine 1998;16:150.
13. Isaka M, Yasuda Y, Mizokami M et al. Mucosal immunization against hepatitis B virus by intranasal co-administration of recombinant hepatitis B surface antigen and recombinant cholera toxin B subunit as an adjuvant. Vaccine 2001;19:1460.
14. Bregenholt S, Wang M, Wolfe T et al. The cholera toxin B subunit is a mucosal adjuvant for oral tolerance induction in type 1 diabetes. Scand J Immunol 2003;57:432.
15. Woogen SD, Ealding W, Elson CO. Inhibition of murine lymphocyte proliferation by the B subunit of cholera toxin. J Immunol 1987;139:3764.
16. Woogen SD, Turo K, Dieleman LA, Beagley KW, Elson CO. Inhibition of murine T cell activation by cholera toxin B subunit is not mediated through the phosphatidylinositol second messanger system. J Immunol 1993;150:3274.
17. Simmons CP, Ghaem-Magami M, Petrovska L et al. Immunomodulation using bacterial enterotoxins. Scand J Immunol 2001;53:218.
18. Yamamoto M, McGhee JR, Hagiwara Y, Otake S, Kiyono H. Genetically manipulated bacterial toxins as a new generation mucosal adjuvant. Scand J Immunol 2001;53:211.
19. Bregenholt S, Röpke M, Skov S, Claesson MH. Ligation of MHC class I molecules on peripheral blood lymphocytes induces new phenotypes and functions. J Immunol 1996;157:993.
20. + T-cells from SCID mice with inflammatory bowel disease. Eur J Immunol 1998;28:3655.
21. Sobel DO, Yankelevich B, Goyal D, Nelson D, Mazumder A. The B-subunit of cholera toxin induces immunoregulatory cells and prevent diabetes in the NOD mouse. Diabetes 1998;47:186.
22. Boirivant M, Fuss IJ, Ferroni L, De Pascale M, Strober W. Oral administration of recombinant cholera toxid subunit B inhibits IL-12-mediate murine experimental (trinitrobenzene sulfonic acid) colitis. J Immunol 2001;166:3522.
23. Matousek MP, Nedrud JG, Harding CV. Distinct effects of recombinant cholera toxin B subunit and holotoxin on different stages of class II MHC antigen processing and presentation in macrophages. J Immunol 1996;156:4137.
24. Li TK, Fox BS. Cholera toxin B subunit binding to an antigen-presenting cell directly co-stimulates cytokine production from a T cell clone. Int Immunol 1996;8:1849.
25. Burkart V, Kim YE, Hartmann B et al. Cholera toxin B pretreatment of macrophages and monocytes diminishes their proinflammatory responsiveness to lipopolysaccharide. J. Immunol 2002;168:1730.
26. George-Chandy A, Eriksson K, Lebens M, Nordström I, Schön E, Holmgren J. Cholera toxin B subunit as a carrier molecule promotes antigen presentation and increases CD40 and CD86 expression on antigen presenting cells. Infect Immun 2002;69:5716.
27. Francis ML, Ryan J, Jobling MG, Holmes RK, Moss J, Mond JJ. Cyclic AMP-independent effect of cholera toxin on B cell activation. II. Binding of ganglioside GM1 induces B cell activation. J Immunol 1992;148:1999.
28. Yankelevich B, Soldatenkov VA, Hodgson J, Polotsky AJ, Cresswell K, Mazumder A. Differential induction of programmed cell death in CD8+ and CD4+ T cell by the B subunit of cholera toxin. Cell Immunol 1996;168:229.
29. Elson CO, Solomon S. Activation of cholera toxin-specific T cells in vitro. Infect Immun 1990;58:3711.
30. Elson CO, Holland SP, Dertzbaugh MT, Cuff CF, Anderson AO. Morphologic and functional alterations of mucosal T cells by cholera toxin and its B subunit. J Immunol 1995;154:1032.
31. Burkart V, Kim Y, Kauer M, Kolb H. Induction of tolerance in macrophages by cholera toxin B chain. Pathobiology 2002;67:314.