The effects of inhibiting P18INK4C expression on the invasion of gastric adenocarcinoma cell line

Acta Biochimica et Biophysica Sinica

Volumn 35, Issue 6, 2003, Pages 511-517

  Wang, Chu ^a   Wang, Jian Hua ^a   Li, Feng ^a   Lu, Jian ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Human gastric adenocarcinoma; Invasion and metastasis; P18INK4C

Indexed keywords

COMPLEMENTARY RNA; CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN; PROTEIN P18; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CELL CYCLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; HUMAN; HUMAN CELL; PLASMID; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA; VISCERAL METASTASIS;

ADENOCARCINOMA; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P18; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN KINASE INHIBITORS; RNA, ANTISENSE; STOMACH NEOPLASMS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0042887319     PISSN: 05829879     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Jeffrey PD, Tong L, Pavletich NP. Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. Genes Dev, 2000, 14(24):3115-3125
2. Noh SJ, Li Y, Xiong Y, Guan KL. Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6. Cancer Res, 1999, 59(3): 558 -564
3. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/cdk4. Nature, 1993, 366(6456):704-707
4. Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG et al. Growth suppression by p18, a p16INK4/MTS1-and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev, 1994, 8(24):2939-2952
5. Hannon GJ, Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature, 1994, 371(6494):257-261
6. Chan FK, Zhang J, Chen L, Shapiro DN, Winoto A. Identification of human and mouse p19, a novel CDK4/CDK6 inhibitor with homology to p16ink4. Mol Cell Biol, 1995, 15:2682-2688
7. Hirai H, Roussel MF, Kato J, Ashmun RA, Sherr CJ. Novel INK4 proteins, p19 and p18, are specific inhibitors of cyclin D-dependant kinases CDK4 and CDK6. Mol Cell Biol, 1995, 15:2672-2681
8. Guan KL, Jenkins CW, Li Y, O'Keefe CL, Noh S, Wu X, Zariwala M et al. Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. Mol Biol Cell, 1996, 7:57-70
9. Aprelikova O, Xiong Y, Liu ET. Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase. J Biol Chem, 1995, 270:18195-18197
10. Platz A, Hansson J, Ringborg U. Screening of germline mutations in the CDK4, CDKN2C and TP53 genes in familial melanoma: A clinic-based population study. Int J Cancer, 1998, 78(1):13-15
11. He J, Hoang-Xuan K, Marie Y, Leuraud P, Mokhtari K, Kujas M, Delattre JY et al. P18 tumor suppressor gene and progression of oligodendrogliomas to anaplasia. Neurology, 2000, 55(6):867-869
12. Arcellana-Panlilio MY, Egeler RM, Ujack E, Pinto A, Demetrick DJ, Robbins SM, Coppes MJ. Decreased expression of the INK4 family of cyclin-dependent kinase inhibitors in Wilms tumor. Genes Chromosomes Cancer, 2000, 29(1):63-69
13. Sotilio R, Garcia JF, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M. Invasive melanoma in Cdk4-targeted mice. Proc Natl Acad Sci USA, 2001, 98(23):13312-13317
14. Bartkova J, Thullberg M, Rajpert-De Meyts E, Skakkebaek NE, Bartek J. Cell cycle regulators in testicular cancer: Loss of p18INK4C marks progression from carcinoma in situ to invasive germ cell tumours. Int J Cancer, 2000, 85(3):370-375
15. Latres E, Malumbres M, Sotillo R, Martin J, Ortega S, Martin-Caballero J, Flores JM et al. Limited overlapping roles of P15 (INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J, 2000, 19(13):3496-3506
16. Wang JH, Chen SS. Screening and identification of gastric adenocarcinoma metastasis-related genes by using cDNA microarray coupled to FDD-PCR. Acta Biochim Biophys Sin, 2002, 34(4):475-481
17. Smith PK, Krohn RI, Hermanson GT, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK et al. Measurement of protein using bicinchoninic acid. Anal Biochem, 1985, 150(1):76-85
18. Lei QY, Wang LY, Dai ZY, Zha XL. The relationship between PTEN expression and anoikis in human lung carcinoma cell lines. Acta Biochim Biophys Sin, 2002, 34(4):463-468
19. Mensing H, Pontz BF, Muller PK, Ganss-Muller V. A study on fibroblast chemotaxis using fibronectin and conditioned medium as chemoattractants. Eur J Cell Biol, 1983, 29(2):268-273
20. Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson SA, Kozlowski JM, McEwan RN. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res, 1987, 47:3239-3245
21. Pepper MS. Lymphangiogenesis and tumor metastasis: Myth or reality? Clin Cancer Res, 2001, 7:462-468
22. John A, Tuszynski G. The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol Oncol Res, 2001, 7:14-23
23. Sobel ME. Metastasis suppressor genes. J Natl Cancer Inst, 1990, 82(4):267-276
24. Keller SM, Adak S, Wagner H, Herskovic A, Komaki R, Brooks BJ, Perry MC et al. A randomized trial of postoperative adjuvant therapy in patients with completely resected stage II or IIIA non-small-cell lung cancer. Eastern Cooperative Oncology Group. N Engl J Med, 2000, 343:1217-1222
25. Sleeman Jp. The lymph node as a bridgehead in the metastatic dissemination of tumors. Recent Result Cancer Res, 2000, 157:55 -81
26. Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T et al. Invovlement of chemokine receptors in breast cancer metastsis. Nature, 2001, 410:50-56
27. Hibi K, Llu Q, Beaudry GA, Madden SL, Westra WH, Wehage SL, Yang SC et al. Serial analysis of gene expression in non-small cell lung cancer. Cancer Res, 1998, 58:5690-5694
28. Weston WM, LeClair EE, Trzyna W, McHugh KM, Nugent P, Lafferty CM, Ma L et al. Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult king. J Biol Chem, 1999, 274:13698-13703
29. Krus-Berthier L, Jan M, Guilbaud N, Naze M, Pierre A, Atassi G. Histology and sensitivity to anticancer drugs of two human non-small cell lung carcinomas implanted in the pleural cavity of nude mice. Clin Cancer Res, 2000, 6:297-304
30. Franklin DS, Godfrey VL, Lee H, Kovalev GI, Schoonhoven R, Chen-Kiang S, Su L et al. CDK inhibitors p18 (INK4c) and p27 (Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev, 1998, 12(18):2899-2911