Assessment of hypolactasia and site-specific intestinal permeability of differential sugar absorption of raffinose, lactose, sucrose and mannitol

Clinical Chemistry and Laboratory Medicine

Volumn 41, Issue 8, 2003, Pages 1056-1063

  Hessels, Jan ^a   Eidhof, Harry H M ^a   Steggink, Jan ^a   Roeloffzen, Wilfried W H ^a   Wu, Kalung ^a   Tan, Guy ^b   van de Stadt, Jan ^c   van Bergeijk, Leo ^a  

^a TWENTEBORG HOSPITAL   (Netherlands)

^b Streekziekenhuis Midden Twente ^*  (Netherlands)

^c Laboratory for Pathology   (Netherlands)

Author keywords

Celiac disease; Crohn's disease; Hypolactasia; Hyposucrasia; Intestinal permeability; Lactose; Mannitol; Raffinose; Sucrose

Indexed keywords

INTESTINE ENZYME; LACTASE; LACTOSE; MANNITOL; RAFFINOSE; SUCROSE;

ADULT; AGED; ARTICLE; CARBOHYDRATE ABSORPTION; CELIAC DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROHN DISEASE; DIAGNOSTIC ACCURACY; DISEASE MARKER; DOSE RESPONSE; DUODENUM BIOPSY; DUODENUM INJURY; ENZYME ACTIVITY; FEMALE; GASTROINTESTINAL SYMPTOM; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; ILEUM DISEASE; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; LACTASE DEFICIENCY; LACTOSE TOLERANCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; URINARY EXCRETION; VOLUNTEER;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; BIOPSY; BLOOD GLUCOSE; CARBOHYDRATES; CELIAC DISEASE; CROHN DISEASE; DATA INTERPRETATION, STATISTICAL; DUODENOSCOPY; FEMALE; GASTROINTESTINAL DISEASES; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; LACTOSE; LACTOSE INTOLERANCE; LACTOSE TOLERANCE TEST; MALE; MANNITOL; MIDDLE AGED; RAFFINOSE; ROC CURVE; SUCROSE;

EID: 0042855203     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2003.163     Document Type: Article

References (36)

1. Juby LD, Rothwell J, Axon AT. Cellobiose/mannitol sugar test - a sensitive tubeless test for coeliac disease: results on 1010 unselected patients. Gut 1989; 30:476-80.
2. Van Elburg RM, Uil JJ, Mulder CJ, Heymans HS. Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease. Gut 1993; 34:354-7.
3. Cobden I, Dickinson RJ, Rothwell J, Axon AT. Intestinal permeability assessed by excretion ratios of molecules: results in coeliac disease. Br Med J 1978; 2:1060-1.
4. Noone C, Menzies IS, Banatvala JE. Scopes JW. Intestinal permeability and lactose hydrolysis in human rotaviral gastroenteritis assessed simultaneously by non-invasive differential sugar permeation. Eur J Clin Invest 1986; 16:217-25.
5. Juby LD, Rothwell J, Axon AT. Lactulose/mannitol test: an ideal screen for celiac disease. Gastroenterology 1989; 96:79-85.
6. Uil JJ, van Elburg RM, van Overbeek FM, Meyer JW, Mulder CJ, Heymans HS. Follow-up of treated coeliac patients: sugar absorption test and intestinal biopsies compared. Eur J Gastroenterol Hepatol 1996; 8:219-23.
7. Cobden I, Hamilton I, Rothwell J, Axon AT. Cellobiose/mannitol test: physiological properties of probe molecules and influence of extraneous factors. Clin Chim Acta 1985; 148:53-62.
8. Lobley RW, Burrows PC, Warwick R, Dawson DJ, Holmes R. Simultaneous assessment of intestinal permeability and lactose tolerance with orally administered raffinose, lactose and L-arabinose. Clin Sci 1990; 79:175-83.
9. Turner JR, Rill BK, Carlson SL, Carnes D, Kerner R, Mrsny RJ, et al. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am J Physiol 1997; 273:C1378-85.
10. Menzies IS. Absorption of intact oligosaccharide in health and disease. Biochem Soc Trans 1974; 2:1042-7.
11. Hessels J, Snoeyink EJM, Platenkamp AJ, Voortman G, Eidhof HHM. Assessment of intestinal permeability: enzymatic determination of urinary mannitol, raffinose, sucrose and lactose on Hitachi analyzer. Clin Chem Lab Med 2003; 41:33-8.
12. Newcomer AD, McGill DB. Distribution of disaccharidase activity in the small bowel of normal and lactase-deficient subjects. Gastroenterology 1966; 51:481-8.
13. Rings EHHM, Grand RJ, Büller HA. Lactose intolerance and lactase deficiency in children. Curr Opinion Pediatr 1994; 6:562-7.
14. Van Beers EH, Rings HHM, Taminiau JAJM, Heyman HSA, Einerhand AWC, Dekker J, et al. Regulation of lactase and sucrase-isomaltase gene expression in the duodenum during childhood. J Pediatr Gastroenterol Nutr 1998; 27:37-46.
15. Nieminen U, Kahri A, Savilahti E, Färkilii MA. Duodenal disaccharidase activities in the follow-up of villous atrophy in coeliac disease. Scan J Gastroenterol 2001; 36:507-10.
16. Heitlinger LA, Rossi TM, Lee P, Lebenthal E. Human intestinal disaccharidase activities: correlation with age, biopsy technique, and degree of villous atrophy. J Pediatr Gastroenterol Nutr 1991; 12:204-8.
17. Newcomer AD, McGill DB. Lactose tolerance tests in adults with normal lactase activity. Gastroenterology 1966; 50:340-6.
18. Maxton DG, Catt SD, Menzies IS. Combined assessment of intestinal disaccharidases in congenital asucrasia by differential urinary disaccharide excretion. J Clin Pathol 1990; 43:406-9.
19. Bjarnason I, Batt R, Catt S, Macpherson A, Maxton D, Menzies IS. Evaluation of differential disaccharide excretion in urine for non-invasive investigation of altered intestinal disaccharidase activity caused by α-glucosidase inhibition, primary hypolactasia and coeliac disease. Gut 1996; 39:374-81.
20. Meddings JB, Gibbons I. Discrimination of site-specific alterations in gastrointestinal permeability in the rat. Gastroenterology 1998; 114:83-92.
21. Manning AP, Thompson WG, Heaton KW, Morris AF. Towards positive diagnosis of the irritable bowel syndrome. Br Med J 1978; 2:653-4.
22. Uil JJ. Clinical implications of the sugar absorption test. Chapter 2.3. Sensitivity and specificity of a hyperosmolar and "iso"-osmolar test solution for sugar absorption in recognizing small intestinal mucosal damage in coeliac disease [dissertation]. Utrecht: University Utrecht, 1996.
23. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiological approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 1992; 102:300-54.
24. Solberg HE. Approved recommendation on the theory of reference values. Part 5. Statistical treatment of collected reference limits. J Clin Chem Clin Biochem 1987; 25:645-56.
25. Juby LD, Dixon MF, Axon ATR. Abnormal intestinal permeability and jejunal morphometry. J Clin Pathol 1987; 40:714-8.
26. Sutherland RL, Verhoef M, Wallace JL, Van Rosendaal G, Crutcher R, Meddings JB. A simple, non-invasive marker of gastric damage: sucrose permeability. Lancet 1994; 343:998-1000.
27. Wyatt J, Oberhuber G, Pongratz S, Püspök A, Moser G, Novacek G, et al. Increased gastric and intestinal permeability in patients with Crohn's disease. Am J Gastroenterol 1997; 92:1891-6.
28. Bode S, Gudmand-Høyer E. Incidence and clinical significance of lactose malabsorption in adult coeliac disease. Scand J Gastroenterol 1988; 23:484-8.
29. Duncan A, Park RP, Lee FD, Russell RI. A retrospective assessment of the clinical value of jejunal disaccharidase analysis. Scand J Gastroenterol 1994; 29:1111-6.
30. Young PG, Das L. Influence of duodenal secretions and its components on release and activities of human brush-border enzymes. Biochim Biophys Acta 1990; 1022:393-400.
31. Goda T, Yasutake H, Tanaka T, Takase S. Lactase-phlorizin hydrolase and sucrase-isomaltase genes are expressed differently along the villus-crypt axis of rat jejunum. J Nutr 1999; 129:1107-13.
32. Goda T. Regulation of the expression of carbohydrate digestion/absorption-related genes. Br J Nutr 2000; 84:S245-8.
33. Nichols BL, Dudley MA, Nichols VN, Putman M, Avery SE, Fraley JK, et al. Effects of malnutrition on expression and activity of lactase in children. Gastroenterology 1997; 112: 742-51.
34. Saltzman JR, Russell RM. The aging gut. Nutritional issues. Gastroenterol Clin North Am 1998; 27:309-24.
35. Lee MF, Krasinski SD. Human adult-onset lactase decline: an update. Nutr Rev 1998; 56:1-8.
36. Rijk MCM, Van Schaik A, Van Tongeren JHM. Disposition of mesalazine from mesalazine-delivering drugs in patients with inflammatory bowel disease, with and without diarrhoea. Scand J Gastroenterol 1992; 27:863-8.