Regular salbutamol use increases CXCL8 responses in asthma: Relationship to the eosinophil response

European Respiratory Journal

Volumn 22, Issue 1, 2003, Pages 118-126

  Gordon, John R ^a   Swystun, V A ^b   Li, F ^a   Zhang, X ^a   Davis, X ^b   Hull, P ^b   Cockcroft, D W ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b ROYAL UNIVERSITY HOSPITAL   (Canada)

Author keywords

Allergy; Asthma; Cytokines; Eosinophils; Salbutamol; Sputum

Indexed keywords

BECLOMETASONE DIPROPIONATE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; CROMOGLYCATE DISODIUM; EOTAXIN; FLUTICASONE PROPIONATE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 5; INTERLEUKIN 8; INTERLEUKIN 8 RECEPTOR; IPRATROPIUM BROMIDE; METHACHOLINE; MONOCYTE CHEMOTACTIC PROTEIN 3; RANTES; SALBUTAMOL; TUMOR NECROSIS FACTOR;

ADULT; ARTICLE; ASTHMA; CHEMOTAXIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; CYTOKINE RELEASE; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; EOSINOPHIL; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LEUKOCYTE FUNCTION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROVOCATION TEST; RESPIRATORY TRACT INFLAMMATION; SERODIAGNOSIS; SPUTUM ANALYSIS;

ADULT; ALBUTEROL; ANALYSIS OF VARIANCE; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHODILATOR AGENTS; CHEMOKINES, CXC; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; EOSINOPHILS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; INTERLEUKIN-8; MALE; MIDDLE AGED; SPUTUM; STATISTICS, NONPARAMETRIC; UP-REGULATION;

EID: 0042812412     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.03.00031102     Document Type: Article

References (41)

1. O'Connor BJ, Aikman SL, Barnes PJ. Tolerance to the nonbronchodilator effects of inhaled beta 2-agonists in asthma. N Engl J Med 1992; 327: 1204-1208.
2. Cheung D, Timmers MC, Zwinderman AH, Bel EH, Dijkman JH, Sterk PJ. Long-term effects of a long-acting beta 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma. N Engl J Med 1992; 327: 1198-1203.
3. Cockcroft DW, McParland CP, Britto SA, Swystun VA, Rutherford BC. Regular inhaled salbutamol and airway responsiveness to allergen. Lancet 1993; 342: 833-837.
4. Gauvreau GM, Watson RM, O'Byrne PM. Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation. Am J Respir Crit Care Med 1999; 160: 640-647.
5. Swystun VA, Gordon JR, Davis EB, Zhang X, Cockcroft DW. Mast cell tryptase release and asthmatic responses to allergen increase with regular use of salbutamol. J Allergy Clin Immunol 2000; 106: 57-64.
6. Kay AB, Barata L, Meng Q, Durham SR, Ying S. Eosinophils and eosinophil-associated cytokines in allergic inflammation. Int Arch Allergy Immunol 1997; 113: 196-199.
7. Nocker RE, Out TA, Weller FR, Mal EP, Jansen HM, van der Zee JS. Influx of neutrophils into the airway lumen at 4 h after segmental allergen challenge in asthma. Int Arch Allergy Immunol 1999; 119: 45-53.
8. Turner MO, Hussack P, Sears MR, Dolovich J, Hargreave FE. Exacerbations of asthma without sputum eosinophilia. Thorax 1995; 50: 1057-1061.
9. Benson M, Strannegard IL, Wennergren G, Strannegard O. Interleukin-5 and interleukin-8 in relation to eosinophils and neutrophils in nasal fluids from school children with seasonal allergic rhinitis. Pediatr Allergy Immunol 1999; 10: 178-185.
10. KleinJan A, Dijkstra MD, Boks SS, Severijnen LA, Mulder PG, Fokkens WJ. Increase in IL-8, IL-10, IL-13, and RANTES mRNA levels (in situ hybridization) in the nasal mucosa after nasal allergen provocation. J Allergy Clin Immunol 1999; 103: 441-450.
11. Sehmi R, Cromwell O, Wardlaw AJ, Moqbel R, Kay AB. Interleukin-8 is a chemo-attractant for eosinophils purified from subjects with a blood eosinophilia but not from normal healthy subjects. Clin Exp Allergy 1993; 23: 1027-1036.
12. Lampinen M, Rak S, Venge P. The role of interleukin-5, interleukin-8 and RANTES in the chemotactic attraction of eosinophils to the allergic lung. Clin Exp Allergy 1999; 29: 314-322.
13. Hauser U, Wagenmann M, Rudack C, Bachert C. Specific immunotherapy suppresses IL-8 levels in nasal secretions: A possible explanation for the inhibition of eosinophil migration. Allergology 1997; 20: 184-191.
14. Keatings VM, Evans DJ, O'Connor BJ, Barnes PJ. Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid. Thorax 1997; 52: 372-374.
15. Taha RA, Laberge S, Hamid Q, Olivenstein R. Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients. Chest 2001; 120: 595-601.
16. Gordon JR, Galli SJ. Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via the Fc epsilon RI. Role for mast cell-derived transforming growth factor beta and tumor necrosis factor alpha. J Exp Med 1994; 180: 2027-2037.
17. Gordon JR. TGFbeta1 and TNFalpha secreted by mast cells stimulated via the FcepsilonRI activate fibroblasts for high-level production of monocyte chemoattractant protein-1 (MCP-1). Cell Immunol 2000; 201: 42-49.
18. Cairns CM, Gordon JR, Li F, Baca-Estrada ME, Moyana T, Xiang J. Lymphotactin expression by engineered myeloma cells drives tumor regression: mediation by CD4+ and CD8+ T cells and neutrophils expressing XCR1 receptor. J Immunol 2001; 167: 57-65.
19. Virchow JC Jr, Walker C, Hafner D, et al. T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma. Am J Respir Crit Care Med 1995; 151: 960-968.
20. Ulfman LH, Joosten DP, van der Linden JA, Lammers JW, Zwaginga JJ, Koenderman L. IL-8 induces a transient arrest of rolling eosinophils on human endothelial cells. J Immunol 2001; 166: 588-595.
21. Petering H, Gotze O, Kimmig D, Smolarski R, Kapp A, Elsner J. The biologic role of interleukin-8: functional analysis and expression of CXCR1 and CXCR2 on human eosinophils. Blood 1999; 93: 694-702.
22. Ordonez CL, Shaughnessy TE, Matthay MA, Fahy JV. Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. Am J Respir Crit Care Med 2000; 161: 1185-1190.
23. Linden A. Increased interleukin-8 release by beta-adrenoceptor activation in human transformed bronchial epithelial cells. Br J Pharmacol 1996; 119: 402-406.
24. Tonnel AB, Gosset P, Molet S, Tillie-Leblond I, Jeannin P, Joseph M. Interactions between endothelial cells and effector cells in allergic inflammation. Ann N Y Acad Sci 1996; 796: 9-20.
25. Furuta GT, Ackerman SJ, Varga J, Spiess AM, Wang MY, Wershil BK. Eosinophil granule-derived major basic protein induces IL-8 expression in human intestinal myofibroblasts. Clin Exp Immunol 2000; 122: 35-40.
26. Molet S, Hamid Q, Davoine F, et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 2001; 108: 430-438.
27. Wershil BK, Wang ZS, Gordon JR, Galli SJ. Recruitment of neutrophils during IgE-dependent cutaneous late phase reactions in the mouse is mast cell-dependent. Partial inhibition of the reaction with antiserum against tumor necrosis factor-alpha. J Clin Invest 1991; 87: 446-453.
28. Gordon JR. Monocyte chemoattractant peptide-1 expression during cutaneous allergic reactions in mice is mast cell dependent and largely mediates the monocyte recruitment response. J Allergy Clin Immunol 2000; 106: 110-116.
29. Moller A, Lippert U, Lessmann D, et al. Human mast cells produce IL-8. J Immunol 1993; 151: 3261-3266.
30. Gordon JR, Galli SJ. Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. Nature 1990; 346: 274-276.
31. Compton SJ, Cairns JA, Holgate ST, Walls AF. The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: tryptase induces expression of mRNA for IL-1 beta and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells. J Immunol 1998; 161: 1939-1946.
32. Van Damme J, Wuyts A, Froyen G, et al. Granulocyte chemotactic protein-2 and related CXC chemokines: from gene regulation to receptor usage. J Leukoc Biol 1997; 62: 563-569.
33. (3-73)K11R/G31P antagonizes the neutrophil chemoattractants present in pasteurellosis and mastitis lesions and abrogates neutrophil influx into intradermal endotoxin challenge sites in vivo. Vet Immunol Immunopathol 2002; 90: 65-77.
34. (3-73)K11R/G31P antagonizes ligand binding to the neutrophil CXCR1 and CXCR2 receptors and cellular responses to CXCL8/IL-8. Biochem Biophys Res Commun 2002; 293: 939-944.
35. Farmer P, Pugin J. β-adrenergic agonists exert their "anti-inflammatory" effects in monocytic cells through the IkappaB/NF-kappaB pathway. Am J Physiol Lung Cell Mol Physiol 2000; 279: L675-L682.
36. Au BT, Teixeira MM, Collins PD, Williams TJ. Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol. Br J Pharmacol 1998; 123: 1260-1266.
37. Hallsworth MP, Twort CH, Lee TH, Hirst SJ. Beta(2)-adrenoceptor agonists inhibit release of eosinophil-activating cytokines from human airway smooth muscle cells. Br J Pharmacol 2001; 132: 729-741.
38. Bissonnette EY, Befus AD. Anti-inflammatory effect of beta 2-agonists: inhibition of TNF-alpha release from human mast cells. J Allergy Clin Immunol 1997; 100: 825-831.
39. Nielson CP, Hadjokas NE. Beta-adrenoceptor agonists block corticosteroid inhibition in eosinophils. Am J Respir Crit Care Med 1998; 157: 184-191.
40. Proud D, Reynolds CJ, Lichtenstein LM, Kagey-Sobotka A, Togias A. Intranasal salmeterol inhibits allergen-induced vascular permeability but not mast cell activation or cellular infiltration. Clin Exp Allergy 1998; 28: 868-875.
41. Denburg JA, Gauldie J, Dolovich J, Ohtoshi T, Cox G, Jordana M. Structural cell-derived cytokines in allergic inflammation. Int Arch Allergy Appl Immunol 1991; 94: 127-132.