Stereochemical Requirement at 4-Position of 4-Phenyl-1-arylsulfonylimidazolidinones for their Cytotoxicities

Archives of Pharmacal Research

Volumn 23, Issue 1, 2000, Pages 35-41

  Jung, Sang Hun ^a   Kwak, Suhk Jun ^a   Kim, Nam Doo ^b   Lee, Sang Un ^c   Lee, Chong Ock ^c  

^a Chungnam National University   (South Korea)

^b DongWha Pharm Ind Co   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

4 Phenyl 1 arylsulfonylimidazolidinones; Cytotoxicity; Stereochemical requirement

Indexed keywords

ANTINEOPLASTIC AGENT; IMIDAZOLE DERIVATIVE;

ARTICLE; CELL CULTURE; CONFORMATION; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; HUMANS; IMIDAZOLES; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034137909     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02976463     Document Type: Article

References (10)

1. Everitt, E., Wohlfart, C., Spectrometric quantisation of anchorage-dependent cell numbers extraction of naphthol blue-black-stained cellular protein. Anal. Biochem., 162, 122-129 (1987).
2. Houghton, P. J., Houghton, J. A., Antitumor diarylsulfonylureas: novel agents with unfulfilled promise, Investigational New Drugs, 14, 271-280 (1996).
3. Howbert, J. J., Sulofenur. Drug of Future, 16, 517-520 (1991) references therein.
4. Jung, S.-H., Kwak, S.-J., Planar structural requirement at 4-position of 1-arylsulfonyl-4-phenyl-4,5-dihydro-2-imidazolones for their cytotoxicity, Arch. Pharm. Res., 20, 283-287 (1997).
5. Jung, S.-H., Lee, H.-S., Song, J.-S., Kim, H.-M., Han, S.-B., Lee, C.-W., Lee, M., Choi, D.-R., Lee, J.-A., Chung, Y.-H., Yoon, S.-J., Moon, E.-Y., Hwang, H.-S., Seong, S.-K., Lee, D.-K., Synthesis and antitumor activity of 4-phenyl-1-arylsulfonylimidazolidinones, Bioorg. & Med. Chem. Letters, 8, 2553-2558 (1997).
6. Jung, S.-H., Song, J.-S., Lee, H.-S., Choi, S.-U., Lee, C.-O., Synthesis and evaluation of cytotoxicity of novel arylsulfonylimidazolidinones containing sulfonylurea pharmacophore. Arch. Pharm. Res., 19, 570-580 (1996).
7. Jung, S.-H., Song, J.-S., Lee, H.-S., Choi, S.-U., Lee, C.-O., Synthesis and evaluation of cytotoxic activity of novel arylsulfonylimidazolidinones. Bioorg. & Med. Chem. Letters, 6, 2553-2558 (1996).
8. Park, K.-L., Moon, B.-C., Jung, S.-H, Kim, J.-G., Suh, I.-W., Totaumeric evidence in an arylsulfonylimidazolone hydrochloride, Acta Cryst., submitted (1999).
9. Skehan, P., Storeng, R., Scudiero, D. A., Monks, A., MacMahon, J., Vista, D. T., Kenny, S., Boyd, M. R. New colorimetric cytotoxicity assay for anticancer drug screening. J. Natl. Cancer Inst., 82, 1107-1112 (1990).
10. Stewart, I. J. F., MOPAC : A semiempirical molecular orbital program. J. Comput.-Aided Mol. Des., 37, 323-325 (1990).